Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 123 for “"keratinocyte"”.
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Stress and Growth Related Keratinocyte Pathways
… specifically characterize the role of IEX-1 in keratinocytes. Special emphasis was directed to elucidating the cellular response to stress and mitogenic stimulation and the role of IEX-1 in mediating apoptosis as well as localizing the protein within the cell during these events. By northern …
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Stochasticity and order: studies of keratinocyte proliferation
… The wide range of colony sizes in cultured human keratinocytes has been taken to support this hypothesis. Contrary to this model, researchers using genetic lineage tracing in mouse epidermis have inferred a single progenitor population for homeostasis, and a quiescent stem cell population …
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Keratinocyte gene expression in psoriasis and eczematous diseases.
Contains fulltext : 87877.pdf (Publisher’s version ) (Open Access)
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MicroRNA-184: A Multifaceted Regulator of Epidermal Keratinocyte Biology
… insults. Consisting of dynamic outer strata of keratinocytes that terminally differentiate from basal keratinocytes stem cells (KSC), the epidermis is maintained by constant spatial and temporal control. In psoriasis, a dysregulated and intensifying crosstalk between keratinocytes and immune …
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A study of keratinocyte differentiation and adhesion in vitro
… culture system to investigate calcium-induced keratinocyte differentiation. Treating normal human keratinocytes with high extracellular calcium concentrations (1mM) increased the proportion of cells expressing differentiation-specific proteins. I showed that this was not caused by …
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The role of translation in keratinocyte cell fate determination.
… to maintain tissue homeostasis. Cultured human keratinocytes generate a range of colony sizes, but can be separated into two groups based on the ratio of outcomes after cell division. On average, ‘balanced’ colonies give rise to equal numbers of proliferative and differentiating cells, whereas …
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Role of Stat3 In Keratinocyte Stem Cells During Skin Tumorigenesis
… of Stat3 deletion or activation on behavior of keratinocytes, including keratinocyte stem cells (KSCs). Deletion of Stat3 specifically in the bulge region of the hair follicle using K15.CrePR1 X Stat3<sup>fl/fl </sup>mice led to decreased tumor development by altering survival of bulge region …
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Longitudinal Keratinocyte Proliferation Induced by Human Papillomavirus 16E6 and NFX1-123 Partnership
… we quantify the growth rates of 16E6-expressing keratinocytes with endogenous or overexpressed NFX1-123 (16E6/vec and 16E6/FN123, respectively) levels by measuring population doublings and interrogate whether proteome expression changes occur early or late in longitudinal growth assays that began …
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Functional study of Gap Junctional Intercellular Communication in Human Keratinocyte Cell Line
… non-tumorigenic and a highly diffenrentiating keratinocyte(HaCaT) cell line was used to find substances that can change the GJIC function via fuctional study using scrape-loading dye transfer(SLDT) method. Toxic drug level of acetic acid , H₂O₂, dexamethasone, Epicatechin …
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Analysis of keratinocyte gene expression: a tale of molecules, markers, models and medicines
Contains fulltext : 11157.pdf (Publisher’s version ) (Open Access)
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Molecular changes involved in oral cancer progression and their relevance to keratinocyte immortalisation
Oral cancer has caused great concern in all of the western countries over the past two decades because of its progressively increasing incidence, mainly in young males, and its consistently low 5-year survival rate. Oral premalignant lesions (dysplasias) are thought to precede the development of …
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The effect of UVA irradiation on the DNA damage response in a human keratinocyte cell line
The DNA damage response (DDR) recognises different types of DNA damage and initiates signalling pathways to bring about cell cycle arrest so the appropriate repair mechanisms can be activated, or to bring about cell death when the damage is unrepairable. DNA damage surveillance and repair pathways …
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HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
… we demonstrate that deletion of E6AP in keratinocytes delayed the onset of differentiation and the abundance of E6AP is reduced in HPV-infected tissue. RNA sequencing revealed similar transcriptional profiles of E6-expressing cells and E6AP-/- cells. Amongst the pathways identified, YAP …
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The effects of TGF-β on the behaviour of a keratinocyte cell line: implications in wound repair
… has tended to focus on fibroblasts. However, keratinocytes play a major role in scarring both indirectly, as a result of their influence over the behaviour of fibroblasts and also by directly influencing wound contraction. Thus, experiments were carried out to investigate the influence of …
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Preserved extracellular matrix in non-enzymatically detached cultured keratinocyte sheets bolsters the healing effects on grafted burn wounds
… To overcome this obstacle, cultured autologous keratinocyte sheets (KS) have been proposed to substitute the autologous skin; however, this technology has not been translated to clinical practice because of the poor quality of KS. Although the exact reason remains unknown, it is suggested that …
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Adipose stromal cells enhance keratinocyte survival and migration in vitro, and graft revascularization in mouse wound healing model
… both survival and migration of human epidermal keratinocytes compared to control medium. In a full thickness wound healing model, using healthy NSG mice, the ASC+EC case showed a significantly higher rate of wound closure compared to control. Based on best linear unbiased estimates (BLUE), the …
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An alginate hydrogel matrix for the localised delivery of a fibroblast/ keratinocyte co-culture to expedite wound healing
… in calcium-alginate hydrogel and culture of keratinocytes on the surface. Initially, the use of 5% and 2% w/v alginate hydrogels were investigated. Both scaffolds maintained fibroblast viability for at least 150 days encapsulation and caused reversible mitotic and catabolic inhibition, as …
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An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing
… different ratios of human melanocytes (Mc) to keratinocytes (Kc) in an in vitro co-culture system, in order to ensure pigmentation of the skin and, ii) To understand cellular mechanisms that contribute basic scientific knowledge towards clinically improved wound healing.
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