Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 96 for “"keratin"”.
-
Investigation of Keratin and Keratin-Containing Composite Biomaterials: Applications in Peripheral Nerve Regeneration
Keratins are a family of structural proteins that can be extracted from a variety of sources including wool, nails, skin, hooves, and hair. Keratin can be processed into different constructs such as coatings, scaffolds, and hydrogels, and has shown favorable results when placed in in vitro and in …
-
KERATIN BIOMATERIAL SCAFFOLDS FOR PERIPHERAL NERVE REGENERATION
Peripheral nerve injury is a relevant clinical concern. Although surgical management of these injuries has improved over time, the current "gold standard" for nerve transection injury, autograft, has many limitations. Nerve conduits are used as an alternative to autograft surgery but they are …
-
Mechanistic Investigation of A Hemostatic Keratin Biomaterial
… complicated by uncontrolled bleeding. Human hair keratin biomaterials have demonstrated efficacy in controlling hemorrhage in both small and large animal models; however little is known about the mechanism by which these proteins aid in blood clotting. Inspection of the amino acid sequence of …
-
Studies on a monomer of feather keratin
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1954.
-
Keratin Microparticles for Drug and Cell Delivery
Keratins are a family of proteins found within human hair, skin and nails, as well as a broad variety of animal tissue. Prior research suggests hydrogel constructs of keratin and keratin derivatives exhibit several mechanical and biological properties that support their use for tissue engineering …
-
Interplay Between Keratin and Vimentin Expression in Oral Cancer
… increased expression of differentiation-specific keratins. It is unknown what causes re-expression of keratins when vimentin is inhibited. Although, canonical Wnt signaling may activate NF-κB and repress of keratin and/or induce vimentin expression through β-catenin. We hypothesize that …
-
Aggregation Behavior of Keratin Proteins Determined by Dynamic Light Scattering
Keratin is a biomaterial derived from biological sources and can be used in a variety of medical applications. This study focuses on keratin derived from human hair. Unfortunately, there is not a lot of information in the literature describing how keratin reacts to subtle changes in an aqueous …
-
Keratin Biomaterial Treatments For Burn Injury And Mechanisms Of Tissue Survival
… we endeavored to investigate the potential of keratin biomaterials to mediate such healing. Pilot studies testing treatment of chemical (mouse model) and thermal (swine model) burns showed that a native mixture (termed "crude keratose" throughout this thesis) of keratose was able to promote …
-
Characterization of Meta-Keratin Biomaterials Derived from Human Hair: Applications for Fiber Development
… of the biological environment. Among these, keratin biomaterials derived from human hair have been used for a variety of biomedical applications due to their intrinsic biocompatibility and ability to regulate cellular behavior. The main objective of this dissertation work was to test the …
-
Fabrication, Characterization and Cellular Interactions of Keratin Nanomaterial Coatings for Implantable Percutaneous Prosthetics
… infection-free and mechanically stable. The same keratins that make up the cortex of human hair fibers are found in the fingernail. These cortical human hair keratins can be extracted and purified, and fingernail-specific dimeric complexes coated onto Ti surfaces using silane coupling chemistry. …
-
An Immunochemical Analysis of Alcoholic Hyaline and its Relationship to Keratin Intermediate Filaments
<p>Alcoholic Hyaline (AH) and keratin intermediate filaments possess ultrastructural, biochemical and immunochemical similarities. This study compares human AH, human stratum corneum keratin (HSCK) and normal human liver cytokeratin (HCK) by quantitative immunochemical means, using polyclonal as …
-
Mutable mechanics in biomaterials : a study of trichocyte keratin and Nvjp-1 protein
… study the hierarchical structure of trichocyte keratin proteins with disulfide bonds from a bottom-up approach. We build the first full atomistic structure of keratin k35/k85 heterodimer and upscale to the keratin macrofibril level. Using molecular dynamics simulations, we provide insights into …
-
The separation of ionic and organic mercury from water using milk proteins, xanthates and keratin
… using a sulfur containing structural protein, keratin (hair). Degreased human hair from a local barbershop achieved an 83% removal of divalent mercury from a 10 ppm solution using one part hair per 500 parts solution. When the solution was well agitated, one part of this hair per 500 parts …
-
Effects of Keratin Biomaterial Therapeutics on Cellular and Inflammatory Mechanisms in Injury and Disease Models
Keratins are fibrous structural proteins found in human hair that have been used to develop bioactive and biocompatible constructs for a wide variety of tissue engineering and healthcare applications. Their ubiquity, capacity for self-assembly, ease of use and versatility in blended materials, and …
-
A Keratin Biomaterial for Treatment Following Spinal Cord Hemisection Injury and Investigation of Secondary Damage Mechanisms
Spinal cord injuries (SCI) are a severely debilitating injury that affects about 200,000 people in the United States alone. The only current treatment options include use of steroids, spinal fixation surgery, and rehabilitation, none of which provide any significant recovery of function. SCIs are …
-
PHYSIOLOGIC CHANGES INDUCED BY INTRAVENOUS INFUSION OF KERATIN-DERIVED RESUSCITATION FLUIDS ON EUVOLEMIC AND HYPOVOLEMIC RATS
<bold>Research Problem:</bold> The field of cardiovascular research has evolved significantly over the last decade, and yet cardiovascular related deaths remain a primary cause of trauma related death. Shock and resuscitation are topics of high importance in the field of emergency medicine due to …
-
The effect of heat and moisture on the small angle x-ray diffraction diagram of feather keratin
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Biology, 1949.
Page 1 of 5