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Showing 1 to 2 of 2 for “"karyomegalic interstitial nephritis (KIN)"”.
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Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
… which results in rare chronic kidney disease - Karyomegalic Interstitial Nephritis (KIN). FAN1 is a highly conserved nuclease from yeast to humans. It was first identified in an RNAi screen for proteins necessary for ICL repair and also as a direct interacting partner of FANCI/FANCD2 (ID2) …
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New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… to a hereditable chronic kidney disease called karyomegalic interstitial nephritis (KIN), characterized by widespread karyomegaly, end stage renal disease, and liver dysfunction, suggesting FAN1 may play an important genoprotective role in the kidney and liver. Yet a complete picture of the role …