Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"kappa light chain"”.
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Regulation of Accessibility of the Variable Gene Segments of the Mouse Immunoglobulin Kappa Light Chain Gene Locus
… of the expression of antibody heavy and light chain molecules is required to fully explain the adaptive immune response. This involves understanding the mechanisms underlying the selection of individual Vκ genes for V-J joining. It has been assumed that this selection involves alterations …
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Molecular Mechanisms Involved in Interleukin-1β Release by Macrophages Exposed to Metal Ions from Implantable Biomaterials
… priming is known to involve nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling. However, the mechanisms of inflammasome activation by metal ions remain largely unknown. The objectives of this thesis were to determine if, in macrophages: 1. IL-1β release induced …
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Herstellung von katalytischen monoklonalen Antikörpern
… against vitamin E (mAb Ing-1, an IgG2a, with kappa light chain and a dissociation constant of KD= 6.72 +/- 2.10 x 10-9 M) have been generated and used for low level detection of vitamin E.
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Construction and mutagenesis of an anti-insulin single chain Fv (scFv) using protein engineering techniques: Identification of peptide mimotopes which inhibit scFv-insulin binding.
… cloned independently as V(H) and V(k). A single chain Fv (scFv) was constructed using a polymerase chain reaction (PCR) assembly technique from the anti-insulin V(H) and V(k). The scFv demonstrated similar, but not identical binding properties to the parental anti-insulin antibody. Binding of …
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The role of type I interferon in chronic lymphocytic leukemia
… oxidative stress, and reduce nuclear factor kappa light chain enhancer of activated B cells (NFκB) signaling within CLL cells in vivo and in vitro. Increased IFN-signaling was associated with loss of an initial clinical response to anakinra. The results from this trial suggested anakinra acts …
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Testing the Anti-Inflammatory Effects of Dietary Phytochemicals in Intestinal Inflammation Models
… transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ƙB) which promotes transcription of neutrophil gelatinase associated lipocalin (NGAL), an antibacterial protein positively correlated with UC severity. Accordingly, we hypothesized that CA would …
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HETEROGENEITY OF LATENCY ESTABLISHMENT IN DIFFERENT HUMAN CD4+ T CELL SUBSETS STIMULATED WITH INTERLEUKIN-15
… the cellular distribution of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor, which is important for HIV expression, we observed that nuclear levels of NF-κB were lower in naïve compared to the other memory subsets, thus partially explaining the …
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Transcriptional and Post-transcriptional Control of Nhlh2 with Differing Energy Status
… -47, -65, -80, -281, -294 and two Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NFκB) binding site motifs at -67 and -135. While NFκB acts as a negative regulator of Nhlh2, this research showed that Stat3 acts as a regulator for the Nhlh2 basal expression and leptin stimulation. …
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Das Leichtketten-Kappa-Immunglobulinrepertoire in der kindlichen Tonsille
Die kappa Leichtketten Rearrangements von den verschiedenen B Zelluntergruppen in Keimzentren der kindlichen Tonsille wurden mit Hilfe der Einzelzell PCR analysiert. Sie wurden anschliessend mit IgD+ B Zellen aus dem Nabelschnurblut und IgM+ B Zellen aus dem Erwachsenenblut verglichen. Analysiert …
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Phytochemical and biological investigation of Lathyrus linofilius as a possible treatment in diabesity
… ofLathyrus linifolius to inhibit nuclear factor kappa-light-chain-enhancer of activated Bcells (NF-ƙB) in the NCTC cell line (human skin cells transfected with a NF-ƙBluciferase reporter vector, used in anti-inflammatory studies). Betulinic acid, ethylacetate extract of the tubers, hexane and …