Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 73 for “"kanamycin"”.
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Single Step Synthesis of Antibiotic Kanamycin Embedded Gold Nanoparticles for Efficient Antibacterial Activity
… biomedical applications. In current research, kanamycin embedded GNPs were prepared in a single step, single phase, and bio-friendly (green synthesis) procedure. The synthesized Kanamycin-GNPs (Kan-GNPs) were spherical in shape and had a size range of 15 ± 3 nm. The chosen kanamycin is an …
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One-Step Synthesis of Kanamycin Functionalized Gold Nanoparticles With Potent Antibacterial Activity Against Resistant Bacterial Strains
… In this study, we report a one-step synthesis of kanamycin-capped GNPs (20 ± 5 nm) utilizing the combined reducing and capping ability of the aminoglycoside antibiotic, kanamycin. Antibacterial assays showed dosedependent broad spectrum activity of Kan-GNPs against Gram-positive (Staphylococcus …
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Seed germination, kanamycin sulfate selection, and the influence of nitrogen treatments on an insertional mutant population of Fragaria vesca
… vesca, various methods of seed germination, kanamycin screening, and the effects of varying nitrogen fertilization on diploid strawberry have been examined. Seed germination was improved to 42% in B5 liquid medium compared to _ on MS solid medium. Kanamycin screening during germination was …
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Genetic and pharmacokinetics factors associated with susceptibility to kanamycin induced cochleotoxicity in a cohort of patients undergoing MDR/RR-TB treatment
… at the time of the present study included Kanamycin, an aminoglycoside with a known cochleotoxic effect. Although kanamycin has recently been removed from the WHO MDR/RR-TB regimen, amikacin, another aminoglycoside derived from kanamycin, with similar structure and cochleotoxic side …
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Construction of bovine adenovirus type 3 E1 and E3, substitution plasmids and the sequencing analysis of DNA pol and pTP /
… a BAV3 E1 or E3 recombinant vector carrying the kanamycin resistant gene, a dominant selectable marker with useful applications in studying vectored gene expression in mammalian cells. To accomplish the objective of this study, more information about BAV3 DNA sequences was required in order to …
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An assessment of antibiotic resistant bacteria in biosolid used as garden fertilizer
… to tetracycline, ampicillin, streptomycin, kanamycin and chloramphenicol. Tetracycline resistant bacteria were isolated on MacConkey's agar supplemented with tetracycline and their resistance to ampicillin, streptomycin, chloramphenicol and kanamycin were also determined. A total of 48 …
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Effectiveness of different medical interventions implemented when a change in hearing status is detected during ototoxicity monitoring
… Patients who underwent RR/MDR-TB treatment with Kanamycin, a cochleotoxic aminoglycoside, at Brooklyn Chest Tuberculosis Hospital (BCH) between June to December 2016 were recruited to participate in the study. Only patients (n= 69) with normal hearing thresholds (i.e., pure tone average (PTA) at …
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Analysis of the vlpA genes and their roles in the pathogenesis of Vibrio cholerae O139 / Pranom Kaewrakon.
… exchange after inactivation via the insertion of kanamycin and tetracycline resistance gene cartridges. The vlpA-negative mutant has been assessed for virulence in the infant mouse cholera model.
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A pharmacometric approach to optimal use of second line drugs for multidrug-resistant tuberculosis
… the addition of a local anaesthetic reduces kanamycin-related injection pain, and explore effects on kanamycin pharmacokinetics. 4. Using geometric mean ratios, compare the exposures of crushed versus whole formulations of pyrazinamide, moxifloxacin, ethionamide, ethambutol, cycloserine, and …
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Prevalence of the gene lsr2 among the genus Mycobacterium and an investigation into changes in biofilm formation when inactivating lsr2 regulated genes in Mycobacterium smegmatis
… Mycobacterial origin of replication and carrying kanamycin resistance and PCR fragments of the target genes. M. smegmatis Δlsr2 was transformed by electroporation and transformants were plated and screened for kanamycin resistance. The mutant strain lacking functional lsr2 and mas (M. smegmatis …
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Baseline prevalence and incidence and risk factors for new-onset drug induced hearing loss in adults receiving drug-resistant tuberculosis (DR-TB) treatment in Khayelitsha, South Africa
… TB. Second line injectable therapy using kanamycin, amikacin or capreomycin is associated with irreversible hearing loss. There is a scarcity of literature regarding the frequency of hearing loss as well as associated risk factors, particularly with long term use. This study aimed to …
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Environmental risk assessment of a genetically-engineered microorganism, Erwinia carotovora
… nutrients monitored. However, transfer of the kanamycin resistance gene that had been inserted into the engineered E. carotovora strain may have occurred. Five species of indigenous bacteria displayed kanamycin resistance 15 days after being exposed to the engineered Erwinia. DNA from these …
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Transformation of Brassica napus cv. Westar with the beet western yellows virus coat protein gene
… recovered under the selection of the antibiotic, kanamycin. Southern blot analysis of Hind digested plant DNA indicated that the BWYV CP gene was present in the genome of three transformed plants (154802-1, 154802-3 and 1557-7). PCR analysis of the same plant genomic DNA followed by Southern blot …
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Attempts toward the expression in transgenic Arabidopsis thaliana of Esi47, a salt stress-induced gene encoding a protein kinase from Lophopyrum elongatum
… inducing medium (SIM) containing 100 $\mu$g/ml kanamycin. Col-2 callus was maintained for three passages on SIM with antibiotics, while the RLD-1 regenerated seedlings were plated directly on hormone free growth medium (GM) with 100 $\mu$g/ml kanamycin for three weeks. All developed roots and …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
… loss and cochlear damage in an inflammatory kanamycin paradigm. Subsequent kinase specific pharmacologic studies refined this finding: systemic JAK1-biased inhibition with upadacitinib or tofacitinib did not produce a statistically significant sensitization phenotype under the conditions …
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Regeneration, DNA Methylation, and Transformation in Rosaceae
The effects of different concentrations of kanamycin, carbencillin, cefotaxime, and combinations of carbencillin and cefotaxime on regeneration from different tissues of rose (Rosa hybrida cv. Carefree Beauty) were investigated. Agrobacerium tumefaciens strain GV3101 containing pCAMBIA 2301 plasmid …
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Identification of new therapeutic compounds against carbapenemase-producing Klebsiella pneumoniae using a novel agar-based high-throughput microarray compound screening approach
… B sulfate, colistin sulfate, gentamicin sulfate, kanamycin sulphate, G418 sulfate, and tobramycin), seven (polymyxin B sulfate, colistin sulfate, gentamicin sulfate, kanamycin sulphate, G418 sulfate, tobramycin, neomycin sulfate), and five (kanamycin sulphate, neomycin sulfate, gentamicin sulfate, …
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Does the inclusion of the cost and burden of adverse drug reactions associated with drug-resistant TB treatment affect the incremental cost-effectiveness of new treatment regimens? A case study from the introduction of bedaquiline in South Africa National TB Programme
… expensive relative to standard regimens using kanamycin was too simple. Particularly, given the high burden of adverse drug reactions (ADR) associated with kanamycin, would the inclusion of the cost and burden of ADR affect the incremental cost effectiveness ratio of a new treatment regimen …
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Genetic engineering for pest resistance in potato (Solanum tuberosum L.)
… All transformed plants rooted on kanamycin-containing medium. Six transgenic lines were challenged with neonate larvae of the potato tuber moth (Phthorimaea operculella). These were three lines from cultivar 'Iwa' and three lines from cultivar 'Red Rascal'. The transgenic status of …
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Pathogenicity Genes of Pseudomonas Syringae Pv. Tabaci Br2
… The Tn5 mutants wre prototrophs, resistant to kanamycin, nalidixic acid, and streptomycin, but sensitive to chloramphenicol. Eight of 2,686 Tn5 mutants showed no symptoms and ten showed reduced symptoms when inoculated onto detached tobacco leaves of Nicotiana tabacum cv. Havana 38, but all …
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