Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"kainate receptors"”.
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Investigations of The Structure-Function Relationship In Kainate Receptors Using FöRster Resonance Energy Transfer
<p>Kainate receptors belong to the family of ion channels known as the ionotropic glutamate receptors. Ionotropic glutamate receptors mediate the majority of excitatory synaptic transmission, modulate the release of presynaptic glutamate, and facilitate dendrite formation. Kainate receptors are …
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A structure-function analysis of the marine toxin neodysiherbaine and its synthetic analogs on kainate receptors
Kainate receptor antagonists show efficacy in multiple animal models of neuropathologies, including pain and epilepsy. These receptors are selectively targeted by a number of natural and synthetic ligands. The goals of this project were to identify compounds with unique specificity for kainate …
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Preclinical Investigations Of Genetic Correlates Of Alcohol Use Disorder
… the ZIP8 transporter, (ii) the GluK1-containing kainate receptors, and (iii) the α5-containing nicotinic acetylcholine receptors (nAChR). First, we describe disturbances in baseline behavior and increased volitional alcohol intake in animals lacking the ZIP8 transporter. We then report the …
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Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology
… of the nature and effects of glutamate receptors activation has major implications in migraine pathophysiology and treatment. Here the role of kainate receptors, a member of the ionotropic glutamate receptors subfamily, was investigated in relaying sensory information upon activation of …
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Modulation of The Receptor Gating Mechanism and Allosteric Communication In Ionotropic Glutamate Receptors
<p>Ionotropic glutamate receptors (iGluRs) found in mammalian brain are primarily known to mediate excitatory synaptic transmission crucial for learning and memory formation. The family of iGluRs consists of AMPA receptors, NMDA receptors and kainate receptors with each member having distinct …
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Cellular mechanisms that modulate kainate receptor trafficking and assembly
Kainate receptors (KARs) in the mammalian brain play a variety of physiological roles that require selective assembly, intracellular trafficking, and synaptic targeting. Cytoplasmic and non-cytoplasmic determinants that modulate KAR expression at the plasma membrane have been recently …
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Hippocampal output to neocortex: Examination of the electrophysiological and plastic properties of CA1 projections to the perirhinal cortex
… and that LTP-induction may require AMPA/kainate receptor activation but not NMDA receptor activation; indicating that glutamatergic signalling underlies synaptic plasticity in this projection. We also determine the role of the CA1 to perirhinal cortex projection in a model of …
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Oligodendrocyte precursor cell states and their regulation
… voltage-gated ion channels and neurotransmitter receptors. Functional expression of these channels and receptors is often described as a defining feature of OPCs, although several reports suggest that OPCs exhibit diversity in their electrophysiological properties. In this thesis, I investigate …
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Tranexamic Acid Modulation of Excitatory and Inhibitory Amino Acid Receptors: A Potential Mechanism for Postoperative Seizures
… enhancing the function of excitatory amino acid receptors (NMDA, AMPA, and kainate receptors). Alternatively, TXA could cause disinhibition by reducing the activity of inhibitory receptors (GABA and glycine receptors). The purpose of this thesis is to identify molecular targets that are sensitive …
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Visualizing the dynamics of ionotropic glutamate receptors using atomic force microscopy
… different subclasses of ionotropic glutamate receptors (iGluRs): AMPA, kainate and NMDA receptors, and triggers a cation influx that generates synaptic currents crucial to brain function. Significantly, iGluRs are implicated in various neurological disorders, such as depression, schizophrenia, …
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Modulation of mechanosensitive gastro-oesophageal vagal afferents by novel targets.
… of signals from peripheral vagal afferent mechanoreceptors to the central nervous system has been identified as the most accessible target for control of neuronal pathways and reflexes central to gastrointestinal disorders such as GORD, disordered food intake and functional dyspepsia. There are …
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Differential Effects of Parkinsonian Toxins and L-DOPA on Locus Coeruleus and Substantia Nigra Neurons: Implications for Parkinson’s Disease
… neurons by indirectly activating α2 and D2 auto-receptors respectively. This effect was attributed to release of NA/DA, since MPP+ did not directly interact with D2 receptors, as shown in membrane binding assays. Additionally, MPP+ caused long-lasting inhibition of nigral dopaminergic neurons by …