Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"juvenile rats"”.
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The Effects of Lipopolysaccharide-induced Neuroinflammation on Learning and Forgetting in Juvenile Rats
… disrupt the memory of fearful contexts in young rats. The current study examined the effect of lipopolysaccharide (LPS), on the memory for a context paired with foot shock in developing rats using the <em>context preexposure facilitation effect</em> (CPFE) procedure. LPS is an endotoxin that …
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Development of the neonatal rat as a model for Sudden Infant Death Syndrome: cardiorespiratory effects of ethanol
… responses to inhaled CO2 challenge in juvenile rats, to determine the age corresponding to the age range of peak incidence of SIDS in human infants. Finally, utilizing the optimized juvenile rat model, the cardiorespiratory responses to ethanol and CO2 challenge were examined. The …
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Changes in Hippocampal Plasticity and HPA Axis Function Following Postnatal Exposure to Di(2-Ethylhexyl) Phthalate in Rats
… activation of HPA axis. DEHP was injected in juvenile rats daily from PND 16 – PND 22. Brain tissue samples were analyzed by immunohistochemistry to quantify developing neurons. The Golgi – Cox Impregnation method was used for detailed morphological analyses. Blood samples were analyzed for …
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Alterations in the Hippocampal Epigenome as a Result of Alcohol Exposure During the Perinatal Period of Development in Rats
… exposure alters the hippocampal epigenome in juvenile rats in a sex-specific manner. A three trimester model of ethanol exposure was used in which pups were exposed to ethanol throughout gestation and from postnatal days (PD) 2 to 10 (ET group). Control groups included rats exposed to the …
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Targeting AMPA Receptor Modulation during Early Life Adversity: A Mediator for Threat Associated Memories
… that there are differences in infant and juvenile threat processing, reflecting age-specific wiring in the brain. However, research still lacks how molecular markers important for synaptic plasticity and memory are modulated across the development after threat exposure.</p> <p>The overall …
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Studies on the effect of growth hormone on age-related changes in glutamatergic transmission in the hippocampus
… to enhance glutamatergic transmission in juvenile rats and to increase mRNA levels of subunits of the AMPA and NMDA types of glutamate receptors. The studies in this dissertation addressed whether deficits in glutamatergic synaptic transmission in old rats are mitigated by treatment with …
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A novel developmental rodent model to investigate the neural basis of episodic memory
… for testing the development of memory in juvenile rats, and to understand if rats show a similar ontogenic profile of memory as humans.<br/>A novel protocol was developed and first tested in adult rats. The protocol was compressed into two days of testing using a battery of spontaneous …
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Enduring Effects of Early Life Inflammation on Stress-related Microglial, Neuronal and Behavioral phenotypes
… key brain regions regulating anxiety. Firstly, juvenile rats with combined but not independent exposures to mHFD+nLPS exhibited altered stress-related transcript abundances in the ventral hippocampus (vHPC) in a manner conducive to potentiating neural stress responses. Surprisingly, mHFD+nLPS …
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Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI
… edema have emerged as therapeutic targets in juvenile TBI. It is therefore important to understand the molecular players and mechanisms involved in TBI-induced BBB disruption in the juvenile brain. To this end, the endothelial caveolins and c-Jun N-terminal kinases (JNKs) were identified as …
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The responses of ventrolateral medullary neurons to hypoxia
… recordings of VLM neurons in anesthetized rats demonstrated a large proportion (64%) which were excited during brief hypoxia (10% O$\sb2$, 60 sec). A similar percentage of VLM neurons (65%) were similarly stimulated in subjects initially peripherally chemodenervated and barodenervated. The …
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The Long-Term Teratogenic Effect of Prenatal Alcohol Exposure on the Somatosensory and Motor Cortex of Rats
… consequences of PAE on SI and MI in 6-week-old (juvenile) or 7-month-old (adult) rats. To accomplish this goal, four major experiments were carried out utilizing a binge-type alcohol exposure paradigm on pregnant rat dams followed by an examination of the PAE pups as well as untreated control and …