Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"junin"”.
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Genetic Determinants of Junin Virus Attenuation
The New World arenavirus Junin (JUNV) is the causative agent of the Argentine hemorrhagic fever (AHF), a deadly disease endemic to central regions of Argentina. The live-attenuated Candid #1 strain of JUNV is currently used to vaccinate human population at risk. However, the mechanism of …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
An unusual feature in the arenavirus envelope glycoprotein complex (GP-C) is the presence of a myristoylated stable signal peptide (SSP) in addition to the receptor binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
An unusual feature in the arenavirus envelope glycoprotein complex (GP-C) is the presence of a myristoylated stable signal peptide (SSP) in addition to the receptor binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the …
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Mechanisms of attenuation of the live Junin virus vaccine strain, Candid #1
… often resulting in potentially lethal disease. Junin virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), is currently the only pathogenic arenavirus for which a vaccine is currently in use. The Candidate #1 (Candid #1) vaccine strain, which was obtained from the 44th mouse …
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A Recombinant Vesicular Stomatitis Virus Expressing the Junin Virus Glycoprotein for Arenavirus Countermeasure Development
… vesicular stomatitis virus expressing the Junin virus glycoprotein (rVSVΔG-JUNVGP) for the development of countermeasures against arenaviruses. First, we evaluated rVSVΔG-JUNVGP as a vaccine against lethal Junin virus (JUNV) challenge in a guinea pig model. Currently, there are no JUNV …
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The introduction of incompatibility between Junin virus Z protein and other viral proteins results in impaired replication and attenuation
… that are pathogenic in human hosts. Among these, Junin virus (JUNV) is a New World mammarenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). AHF resulted in 15-20% case fatality during epidemics until the introduction of a vaccine that drastically reduced the incidence of …
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Genetic diversity and taxonomical relationships among the tacaribe serocomplex viruses (family arenaviridae)
… of the small genomic segments of 12 strains of Junin virus, 7 strains of Machupo virus, and 11 strains of Guanarito virus were determined to improve our knowledge of strain-to-strain genetic variation within these South American arenavirus species. This new knowledge will enable development of …
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Arenavirus Attenuation Mechanisms
Arenaviridae derives from the Latin word ‘arena’ meaning ‘sand’. When scientists first looked at arenavirus virions by transmission electron microscopy, they saw pleomorphic particles that had a sandy appearance. This sandy appearance was due to host ribosomes being incorporated into the virions. …
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Investigations into endothelial cell permeability and adherens junction disruption induced by Junín virus infection.
Junín virus is found in the fertile Pampas of Argentina and is maintained in nature by the rodent host, Calomys musculinus. Junín is the causative agent of Argentine hemorrhagic fever (AHF) characterized by vascular dysfunction and fluid distribution abnormalities. Clinical, as well as experimental …