Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 107 for “"junctional"”.
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Characterization of Arterial Flow for Junctional Bleeding Control
… in order to better understand how to control junctional hemorrhaging. The hypotheses of this study were that length reduction will have little effect on volumetric flowrate and that cross-sectional area reduction would need to be approximately 80 percent in order to obtain bleeding control. …
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Signaling Mechanisms That Control Gap Junctional Coupling Between Retinal Neurons
Gap junctions between neurons form the structural substrate for electrical synapses. Connexin 36 (Cx36, and its non-mammalian ortholog connexin 35) is the major neuronal gap junction protein in the central nervous system (CNS), and contributes to several important neuronal functions including …
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Interplay between Ephaptic and Gap Junctional Coupling in Cardiac Conduction
… of EpC, and its interactions with gap junctional coupling (GJC) and, 2) to investigate the possible role of serum ion modulation in cardiac arrhythmia therapy. First, the effects of altering extracellular ion concentration – sodium, potassium and calcium at varying GJ protein expression …
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Alternative mechanisms of translation initiation in modulation of gap junctional coupling
… mechanism by which cells modulate Cx43 gap junctional coupling in changing conditions and identified a novel regulator of this process in mammalian cells.
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Identificaiton of the pore-lining helices of connexin 43 gap-junctional hemichannels
The gap-junctional channels that mediate intercellular communication are formed by head-to-head docking of two gap-junctional hemichannels from adjacent cells. The hemichannels are hexamers of connexins, proteins that have four transmembrane helices. The transmembrane helices that line the …
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Novel Approach to Junctional Bleeding: Tourniquet Device Proposal for Battlefield Hemorrhage Control
… solutions to the current wartime problem of junctional hemorrhaging, or massive traumatic hemorrhaging in non-tourinquetable areas such as the neck, groin, or armpit. Junctional hemorrhaging has been identified as a major contributor to potentially survivable deaths seen on the battlefield …
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Functional study of Gap Junctional Intercellular Communication in Human Keratinocyte Cell Line
Gap junctions, unique membrane structures that mediate the intercellular communications among almost all tissues, are composed of connexins in vertebrate. The essential role of gap junction-mediated intercellular communications(GJIC) for coordination of cell homeostasis, tissue functions and organ …
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Junctional Sarcoplasmic Reticulum Protein Processing And Trafficking In Cardiac Tissue And Primary Cultured Cardiomyocytes
<p>Junctional SR is an important and unique ER subdomain in the adult myocyte that releases Ca2+ through the actions of an exclusive set of resident proteins. Cardiac calsequestrin (CSQ2) undergoes two co-translational modifications: N-linked glycosylation on 316Asn, and phosphorylation by protein …
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Effects of DDT and DDE on gap junctional intercellular communication in human mammary epithelial cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Role of Connexin43 and Gap Junctional Intercellular Communication in the Apoptotic Process of Auditory Cells
… As a result, I found that inhibition of gap junctional activity with either Cx43 siRNA transfection or a pharmacological drug, 18α-glycyrrhetinic acid in HEI-OC1 auditory cells caused a marked increase in cell viability with a decrease of apoptosis based on cleaved Poly (ADP-ribose) …
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Gingko biloba extracts protect auditory hair cells from cisplatin-induced ototoxicity by inhibiting perturbation of gap junctional intercellular communication
Gap junctional intercellular communication (GJIC) may play an important role in the hearing process. Cisplatin is an anticancer drug that causes hearing loss and Gingko biloba extracts (EGb 761) have been used as an antioxidant and enhancer for GJIC. The purpose of this study was to examine the …
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The use of cultured cells with defects of citrulline metabolism in diagnosis and in the study of intercellular communication
… as an assay system for measuring intercellular junctional communication. This allowed quantitation of the effects of pH and extracellular divalent cations on junctional communication. Tumor promoters such as phorbol esters and organochlorine pesticides have been reported to inhibit intercellular …
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In vitro model of periodontal epithelium
To develop a model for junctional epithelium, porcine periodontal ligament epithelial cells (PLE cells) were cultured from the epithelial rests of Malassez. The obtained epithelial cell lines were grown on a porous membrane that allows a good cell adhesion and access of the nutrients from both …
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The Novel Role of Dnmbp In Kidney Development
… that disruption of Dnmbp affects adhesion and junctional integrity of nephron progenitor cells by significantly reducing junctional E-cadherin localization when compared with standard controls. Additionally, Dnmbp-depleted nephron progenitor cells appear to have disordered membrane borders, …
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Investigating the role of PTPRK in homeostasis and disease
… factors and during essential processes, such as junctional remodelling. Plasma membrane-localised receptor PTPs (RPTP) are well positioned to sense external environmental cues, such as cell-cell contact, and transmit signals via their intracellular domains. Using unbiased approaches we find RPTP, …
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Turnover Rate of The Neuronal Connexin Cx36 In Hela Cells
… (TMR) HaloTag ligand. Cx36-Halo formed large junctional plaques at sites of contact between transfected HeLa cells and was also contained in a large number of intracellular vesicles. The Cx36-Halo transfected HeLa cells supported Neurobiotin tracer coupling that was regulated by activation and …
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An Optogenetic Toolbox for the Interrogation of Dynamic Events During Angiogenesis
… endothelial barrier. VE-Cadherin is an essential junctional protein involved in the maintenance of the endothelial barrier. While many of the components involved in these processes have been characterized, the dynamic changes in VE cadherin interactome induced by angiogenic stimuli have not been …
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Studies on the role of the autonomic nervous system in airway hyperreactivity.
… guinea-pig trachea, suggesting that the pre-junctional K+ - channels involved in modulating vagal tone are functioning normally in sensitized tissues. The sensitization process however, may alter post-junctional K+ - channel behaviour since cromakalim attenuated responses only to lower …
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