Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 607 for “"jun"”.
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Molekulare Mechanismen der transkriptionellen Aktivierung durch die Transkriptionsfaktoren c-Jun und v-Jun
… Mechanismen der Transkriptionsfunktion von c-Jun und v-Jun in drei verschiedenen Ansätzen untersucht. Im ersten Teil der Arbeit konnte gezeigt werden, dass die transkriptionelle Aktivität von v-Jun, im Gegensatz zu den sauren Transkriptionsfaktoren VP16, GCN4 und Hap4, in S.cerevisiae …
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C/EBPalpha downregualtes c-jun expression
… are present. A dramatic increase of c-jun mRNA in C/EBPa knockout mice fetal liver was observed. c-jun, a component of the AP-1 transcription factor complex and a co-activator of the transcription factor PU.1, is important for monocytic differentiation. Here we report that C/EBPa …
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Translational Regulation of the C-Jun Proto-Oncogene
<p>The <em>v-jun</em> oncogene was originally isolated from the ASV17 virus in 1987. Ever since its isolation, extensive work has been done to understand the role of the v-jun oncogene in cell transformation. The c-Jun protein is a transcription factor which binds to the DNA target TGACTCA. The …
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C-Jun N-Terminal Kinases Regulate Adenovirus-Mediated Autophagy and Antigen Presentation
… infection triggered phosphorylation of c-Jun N-terminal kinases (JNK) that was essential for autophagy. Adenoviral replication within the host cell elicited JNK pathway activation leading to B cell lymphoma-2 (Bcl-2) phosphorylation. JNK-dependent Bcl-2 phosphorylation stimulated the …
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Role of c-Jun in the regulation of tumor suppressor p53 homologue, p73
… the first time that the transcription factor c-Jun stabilizes and activates p73. Genetic evidences consolidated the findings, as c-jun-/- cells are defective in p73 stabilization, transcriptional activation, and are resistant to cisplatin induced apoptosis. Upon introducing c-Jun in c-jun-/- …
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Identification and Characterization of Genes Associated with <i>V-Jun</i> Induced Cell Transformation
<p>The <em>v-jun</em> oncogene was initially identified as the causative agent for fibrosarcomas in chickens. Studies show that overexpression of v-Jun proteins transforms chicken embryo fibroblasts (CEF) <em>in vitro</em>, and forms tumors in chickens<em> in vivo</em>. The mechanisms for this are …
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Regulation of jun B gene expression in v-fos tranformed rat-1 fibroblasts and revertants
Thesis (M.S.)--Massachusetts Institute of Technology, Division of Toxicology, 1994.
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The role of c-Jun N-terminal kinase one and two in motoneuron maturation and maintenance
… and Kobe, 2006; Frebel and Wiese, 2006). The c-Jun N-terminal kinases (JNKs) are stress-activated members of the MAPK family, which may represent candidate molecules whose signaling is important in MN death, survival, differentiation, maturation, and maintenance. Classically considered a …
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Elevated temperature alters cytokine output and c-Jun N-terminal kinase signaling downstream of toll-like receptor activation
Fever is a fundamental and important response to infection. Previous studies have shown that alterations in temperature can alter the phenotype of innate immune cells, such as phagocytic ability, but the effects of elevated temperature on the molecular mechanisms that underlie these differences …
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Viral jun oncogene serves as a suppressor of phorbol ester TPA induced tumor cell invasion and stromelysin gene expression
… are believed to be involved. The viral jun (v-jun) oncogene encodes a transcription factor that can participate in the transactivation of genes through the AP-1 complex. Evidence indicates that the ability of v-jun to transform cells and stimulate transcription depends on the cell type. …
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Helicobacter Pylori aktiviert den Transkriptionsfaktor AP-1 über mitogen-aktivierte Proteinkaskaden und induziert die Protoonkogene c-fos und c-jun
… konsekutiv die Transaktivierungskapazität von c-Jun durch Phosphorelierung zu erhöhen. <br>Entscheidend hierbei ist, daß nur H.pylori Stämme mit einer intakten Pathogenitätsinsel cag (u.a. Stamm G27) eine Aktivierung der Signalkaskaden und des Transkriptionsfaktors AP-1 bewirken, H.pylori Stämme …
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Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia
Overexpression of proto-oncogene c-jun and constitutive activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process. However, c-jun expression has not been investigated in acute myeloid leukemia (AML) cells containing the most common …
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Regulation of SPARC Gene Expression by the Activator Protein 1 Transcription Factor
<p>Overexpression of the c-Jun proto-oncogene in MCF7 breast cancer cells results in a variety of phenotypic changes related to malignant progression including a shift to estrogen independent growth, increased cell motility and invasion. Concurrent with these phenotypic changes are alterations to …
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Transcriptional Regulation of Chicken Apolipoprotein A-I Gene Expression
… of the oncogenic transformation induced by v-Jun oncoprotein. In the past several years, extensive efforts have been made to identify such genes. Several target genes have been identified that are specifically associated with the v-Jun induced transformation phenotype in chicken embryo …
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Photic entrainment and induction of immediate-early genes within the rat circadian system
… within the rodent circadian system are Fos and Jun-B. Molecular expression of these two genes within the suprachiasmatic nucleus (SCN) correlates both in magnitude and in the temporal contingency with light-induced behavioral phase shifts. The determination of the role of Fos and Jun-B in …
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