Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"joint inflammation"”.
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Characterization of an in Vivo Model of Temporomandibular Joint Inflammation
… nerves is involved in temporomandibular joint (TMJ) inflamation and pain transmission. The proinflammatory molecule nitric oxide (NO) and protons are implicated in the underlying pathology of temporomandibular joint disorders. The goal of this study was to investigate gap junction …
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SYNDROMIC HIDRADENITIS SUPPURATIVA: GENOTYPE-PHENOTYPE CORRELATION THROUGH WHOLE-EXOME SEQUENCING IN 10 UNRELATED PATIENTS
… identified based on presence/absence of gut and joint inflammation. Four PASH patients who had also gut inflammation showed three different variants in NOD2 gene, two variants in OTULIN, and a variant in GJB2, respectively. Three PAPASH and three PASH/SAPHO overlapping patients who had also joint …
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Mechanisms of synovial fluid lipid-mediated neuronal sensitisation in arthritis
… costs billions to the global economy. Although joint pain is the leading patient-reported symptom of those with arthritis, current analgesics often fail to produce consistent pain relief and, with chronic use, are associated with detrimental side effects. Osteoarthritis (OA) is the most common …
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Knee injuries and their consequences – the impact of impact
… OA secondary to an ACL injury have more joint space narrowing and more osteophytes in the lateral compartment than in the medial compartment, compared with subjects with non-traumatic OA. Furthermore, it was found that an acute knee injury is associated with instant and sustained synovial …
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An Investigation of the Interplay Among CX3CR1, Immune Cells, and Gut Microbiota in Lupus-Associated Arthritis and Renal Disease using the MRL/lpr Mouse
… examining lupus-associated kidney disease and joint inflammation arthritis, CX3CR1 was found to affect them differently. The absence of CX3CR1 worsened kidney disease but improved arthritis. Different immune cells such as T cells and myeloid cells were observed to correlate with arthritis …
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Molecular Players in Lupus: Leads from Proteomic Screens
… antibodies (ANA), rashes and photosensitivity, joint inflammation, nephritis, and other clinical criteria. SLE develops through the breakdown of three major checkpoints: adaptive immune tolerance, peripheral innate responsiveness, and end-organ inflammation. Adaptive immune dysfunction produces …
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Equine Septic Arthritis and Serum Amyloid A
Bacterial infection within a joint, septic arthritis, is a serious condition in horses that can lead to long-term joint disease if the infection is not resolved quickly. Equine septic arthritis is diagnosed primarily based on clinical signs and synovial fluid cytology. Septic synovial fluid is …
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Effect of a single intra-articular injection of bupivacaine on synovial fluid prostaglandin E2 concentrations in normal canine stifles
… chondrotoxicity is unknown, but may involve inflammation. Prostaglandin E2 (PGE2) is an inflammatory mediator and a marker of joint inflammation. The aim of this study was to compare synovial fluid PGE2 concentrations after a single intra-articular injection of bupivacaine with a saline …
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Improving clinical outcomes in rheumatoid arthritis: a patient centred approach
… rheumatoid arthritis (RA) focuses on minimising joint inflammation using suppressive treatments. However, patients have broader concerns spanning other symptoms like fatigue and pain and the way their health care is delivered. This thesis used qualitative and quantitative research methods to …
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A Novel Interleukin-15 Receptor Antagonist for the Treatment of Rheumatoid Arthritis
… in the United States, causing debilitating joint inflammation, pain, and potential disability. Current treatment options, including methotrexate and biologics like adalimumab, have limited efficacy, leaving a substantial number of patients without adequate relief. Interleukin-15 (IL-15), a …
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Evaluation of allogeneic bone marrow-derived mesenchymal stem cells for use in equine joints: in vitro to preclinical evaluation
Joint disease is prominent in the equine population and horses provide a highly translational model for human joint disease. Mesenchymal stem cells (MSCs) have been investigated as a treatment of musculoskeletal disease in the horse with autologous MSCs showing promise as a treatment of desmitis, …
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Diverse roles of cyclooxygenase in the central nervous system and the periphery
… knee arthritis. Arthritis with intra-articular inflammation was accompanied by joint pain, swelling, and stiffness leading to significant functional impairment. Thus, regulation of joint inflammation is a good therapeutic approach for patients with arthritis. COX-2 and prostaglandin is well …
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Macrophage-mediated regulation of joint homeostasis
… and horses, and is characterized by progressive joint degeneration. There is a critical need for a better understanding of disease processes leading to OA in order to develop more efficient therapies. A shared feature among different arthritic conditions is chronic synovitis. Macrophages are the …
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Effector CD4⁺ T lymphocytes in the prodrome of polyarthritis
… considerable body of evidence suggests that the joint destruction is mediated by T cells within the synovium, which may activate other cells such as macrophages and fibroblasts that are more directly implicated in articular damage. To gain a further understanding of the mechanisrns involved in …
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Biotribology: Studies of the Effects of Biochemical Environments on the Wear and Damage of Articular Cartilage
… of biological systems, mainly synovial joints such as the human hip and knee. Osteoarthritis (OA) is partially characterized by the loss of articular cartilage from the contacting surface of the articulating bones in synovial joints. Although it has been studied extensively, the exact …
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REGULATION AND EXPRESSION OF AMYLOID CURLI IN SALMONELLA INFECTION
… an increase in anti-dsDNA autoantibodies and joint inflammation in infected mice. This result demonstrated that a biofilm component expressed in the intestinal tract can trigger subsequent autoimmune responses within the host. Reactive arthritis (ReA) is a painful form of inflammatory …
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The role of IL-27 and IL-35 in inflammatory diseases
… autoimmune disease characterized by chronic inflammation within the synovial tissues in multiple joints leading to progressive, erosive destruction of cartilage and underlying joints. The severity of RA is associated with the overexpression of proinflammatory cytokines within the synovial …
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Formation and Pathogenicity of Cytotoxic Curli Intermediates
… proliferation and periosteal resorption, in the joints of mice autoimmune-prone mice. Together, this data identified that chronic exposure to curli induced autoimmune sequelae which is thought to be transient in genetically healthy individuals, but leads to joint inflammation in individuals whom …
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Regulation of Neuropeptide Y, Vasoactive Intestinal Polypeptide, and Their Receptors in Trigeminal Ganglion Neurons and Glia in Response to Adjuvant-Induced Inflammation
… nerves is involved in temporomandibular joint (TMJ) inflammation and pain transmission. Neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), and their receptors have been implicated in the underlying pathology of temporomandibular joint disorders. The goal of this study was to …
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Inflammatory and Immune Effects of Intra-Articular Mesenchymal Stem Cells in Horses
… as well as modest efficacy in animal models of joint injury, warranting further study as a potential treatment of equine joint disease. The goal of the study is to investigate the inflammatory and immune response to intra-articular injection of autologous, genetically modified (bone …