Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"jak kinases"”.
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Identification of novel components in fibroblast growth factor signalling
… of Src and Janus non receptor tyrosine kinases decreased FGF1-induced tyrosine STAT3 phosphorylation. The findings suggested that FGFR kinase activity was mandatory for physical association between FGFR and STAT3 and its subsequent tyrosine activation by Src and Jak kinases. Moreover, …
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The role of JAK1 and JAK3 in CD8<sup>+</sup> effector T cells
… project was to explore the role of the tyrosine kinases JAK1 and JAK3 in cytokine signalling, focusing on interleukin-2 signalling in CD8<sup>+</sup> effector T lymphocytes. Initial experiments compared the effects of the pan JAK1/JAK3 inhibitor tofacitinib, the selective JAK1 inhibitor GSK186, …
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Role of IL-6/gp130-dependent signalling pathways in hepatocytes during liver regeneration and inflammation
… cellular events started by induction of JAK kinases resulting in Ras/Erk-mediated signalling and activation of STAT transcription factors, particularly STAT3. Within the present studies the role of the Interleukin-6 (IL-6) receptor gp130 in hepatocytes was investigated in terms of liver …