Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"itraconazole"”.
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The use of glutathione in canine itraconazole-associated hepatotoxicity
… azoles in small animal veterinary medicine are itraconazole (ITZ), fluconazole (FCZ), and ketoconazole (KTZ). Owing to its greater selectivity for fungal ergosterol over mammalian cholesterol, ITZ has fewer adverse effects than KTZ. Additionally, it has a broader spectrum of activity than both …
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Repurposing itraconazole as a novel and promising therapeutic strategy for pancreatic cancer
… this thesis has examined repurposing itraconazole, which is an inexpensive and well-tolerated oral antifungal agent currently in use clinically as a novel treatment for pancreatic cancer. We utilised a combination of in vitro and advanced in vivo techniques and models (including mouse …
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Development and manufacture of novel amorphous Itraconazole drug products using quality by design principles
… thesis was to improve the poor solubility of Itraconazole (ITZ) through novel approaches to product development using continuous manufacture with novel in-line process analytical technology (PAT) to monitor quality. The solubility parameter () of ITZ and polymers, Kollidon® VA64 (KOL), …
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Establishment of hedgehog pathway overexpression in osteosarcoma cell lines leading to an anti-apoptotic genotype which can be inhibited by the common anti-fungal and hedgehog pathway inhibitor, itraconazole
… and extrinsic arms of the apoptotic pathway. Itraconazole is an antifungal agent that has been found to inhibit Smoothened (SMO), a crucial G protein-coupled receptor located on the cell membrane and becomes activated on the primary cilium, which allows initiation of HH pathway signaling. We …
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The Influence of PVAP on the Stability of Amorphous Solid Dispersions of Itraconazole Produced using Hot Melt Extrusion Technology
… polymer for supersaturated solutions of itraconazole (ITZ) in neutral pH aqueous media and in the solid-state during storage over time. Polyvinyl pyrrolidone vinyl acetate (PVPVA) was incorporated into PVAP as a carrier matrix with the aim of lowering the melt viscosity and increasing the …
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Investigating MCE Chemical Library Drugs for Combinational Therapies for Clinical Aspergillus fumigatus isolates
… fumigatus infections such as voriconazole (VRC), itraconazole (ITC), and posaconazole (POS) with a reserve of Amphotericin B (AmB). In the past two decades, the emergence of resistance to azoles has contributed to a 90% mortality rate in resistant cases globally. In this report, we investigated …
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Discovery and development of novel antifungal agents for the treatment of Candida auris infections
… activity of azoles (fluconazole, voriconazole, itraconazole, and posaconazole) and polyene (AmB). Mechanistic studies showed that the HIV protease inhibitors inhibited the fungal efflux pump, and interfered with glucose utilization, leading to reduced ATP levels in C. auris. Moreover, HIV …
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Investigating FDA-Approved Drugs for Treatment of Multidrug-Resistant Neisseria gonorrhoeae
… potent and narrow-spectrum novel candidates, itraconazole, isavuconazole, and ravuconazole, are azole antifungals, and their activities were further investigated in vitro. Of the three azoles, ravuconazole displayed the most potent activity against N. gonorrhoeae clinical isolates. The …
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Comparative structural analysis of cytochrome P450 family CYP51 in the genus Cryptococcus
… CYP51s have a high preference for itraconazole, corroborating the in vitro effectiveness of itraconazole compared to fluconazole. Amino acids interacting with different ligands were found to be conserved across CYP51s, indicating that the procedure employed in this study is accurate …
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Novel approaches for ungual and trans-ungual delivery of drugs
… the ungual and trans-ungual permeation of itraconazole for the treatment of onychomycosis. In vitro and ex vivo permeation studies were performed following two protocols, a) pulse application of iontophoresis for 3 days (8 h/day), b) continuous application of iontophoresis for 24 h. The …
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Susceptibility Testing of Pathogenic Fungi With a Radiometric System
… Ketoconazole, Miconazole, Terconazole, and Itraconazole. The instrument used to measure amount of radioactive carbon dioxide generated by fungal metabolism of ¹⁴C-glucose in presence of antifungal agents was the Bactex 460. Mycelial cultures were grown on SAB-DEX agar at 25°C and converted …
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Developing novel drug combinations for treatment of invasive fungal infections
… of azole drugs (fluconazole, voriconazole and itraconazole). We confirmed that lopinavir and ritonavir have the capability to interfere with fungal efflux pump machinery. The in vivo efficacy of the combination of azole antifungals and HIV protease inhibitors was also evaluated to discover the …
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ERG11-Mediated Azole Resistance in Candida albicans
… of amino acid substitutions. Fluconazole, itraconazole and voriconazole susceptibilities for these strains were tested. Our data demonstrated many of these mutations resulted in fluconazole resistance, but most were not as significant when tested against voriconazole or itraconazole. …
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Farmacijos specialistų žinios ir požiūris į gydymo statinais naudą ir jų sukeliamą nepageidaujamą poveikį /
… informed about the interaction of statins with itraconazole and St John's wort, less information had about interactions of atorvastatin with warfarin, and atorvastatin with macrolide group antibiotics, at least information had about amlodipine with simvastatin interaction. 3. Pharmacy …
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Investigations on the antifungal and cancer modulating properties of extracts from selected species of Tulbaghia
… efficacy of the fungicides, SporekilPu, Thiram, Itraconazole and Fluconazole against F. verticil/ioides (MRC 826). Data analysis from in vitro results indicates that for the 16 different mixtures of each plant extract and fungicide combination, several significantly (P<O.05) higher growth …
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Preclinical evaluation of dissolvable microarray patches for allergy treatment: key factors governing in vitro and in silico assessment
… conditions, as well as the systemic exposure of itraconazole in vivo after MAP applications. These results support its potential as a valuable translational tool in early-stage MAP development. In conclusion, this research has significantly advanced our understanding of the complex factors …
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An Investigation into Clinically Relevant Determinants of Azole Resistance in Candida albicans
… amino acid substitutions. In contrast, MICs to itraconazole showed a small, fairly consistent increase in MIC across tested CaCYP51 strains and MICs to posaconazole did not increase at all over the wild type except for the G448E substitution, suggesting posaconazole possesses the best in vitro …