Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 92 for “"isothiocyanate"”.
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GENETIC DISSECTION OF AVERSION TO ALLYL ISOTHIOCYANATE IN Drosophila melanogaster
… responds to many electrophiles, including allyl isothiocyanate (AITC). Drosophila have four homologs to the mammalian TRPA1: dTRPA1, painless, pyrexia, and water witch. dTRPA1 and painless are thought to play a role in the behavioral aversion to AITC, however the role of painless is controversial …
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Allyl isothiocyanate reduces Salmonella enterica Michigan and Listeria monocytogenes on the surface of whole cantaloupe (Cucumis melo L.)
… This research evaluates the use of allyl isothiocyanate (AITC; a natural antimicrobial) to reduce populations of S. enterica Michigan and L. monocytogenes on the surface of cantaloupe. Fifty μl of S. Michigan or L. monocytogenes was inoculated onto whole ‗Athena‘ or ‗Hales Best Jumbo‘ …
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Digestive metabolism of glucosinolates: a novel approach using urinary markers for estimating the release of glucosinolate breakdown products in the gastro-intestinal tract of mammals.
… a range of metabolites including beneficial isothiocyanates. Little is known about the fate of glucosinolates after their ingestion. Using urinary end-products of metabolism as markers, measurement of the production of isothiocyanates in the digestive tract of monogastric animals has been …
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Synthesis of N-alkyl-and N,N-dialkyl-N'-acyl- and N'-aroythioureas, and aspects of their co-ordination chemistry with Pt(II)and Pd(II)
… secondary or primary amine with an acyl or aroyl isothiocyanate. This synthesis requires nucleophilic addition of the amine to the thiocarbonyl carbon of the acyl or aroyl isothocyanate. However, a competitive side-reaction frequently occurs because the amine nucleophile can attack the carbonyl …
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Inhibitory Effects of Isothiocyanates on the Mutagenicity and Metabolism of Environmental Carcinogens
… inhibitory effects of the two naturally occuning isothiocyanates, benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC) on the metabolism and mutagenicity of 4-(methylnitrosamino)-l-(3-pyridyl)-lbutanone (NNK) and benzo[a]pyrene (BaP) by F344 rat and male Syrian golden hamster liver …
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The role of foliar glucosinolates in host plant resistance of oilseed rape and mustard to the Bertha armyworm and the diamondback moth
… were negatively correlated to concentrations of isothiocyanate-releasing glucosinolates. In feeding tests with pure compounds in meridic diets, sinigrin and its metabolite, allyl isothiocyanate inhibited growth in a dose-dependent manner. No effects were observed with indole-3-carbinol, the …
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Structure-activity relationships in Werner clathrates
… following general formula: [NiX2B4] - where X is isothiocyanate or bromine and B is 4-ethylpyridine, 4-vinylpiridine or 3,5-dimethylpyridine; [NiX2B2]n - where X is isothiocyanate, B is 2-aminopyridine and n indicates it is a polymer; [NiX2AB2]2 - where X is isothiocyanate, B is 3-aminopyridine …
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Use of Extraction Technologies in Food Safety Studies
… identify and quantify the flavor component allyl isothiocyanate (AITC) and related compounds in horseradish products. Solvent extraction, headspace sampling, and HS-SPME were compared, and HS-SPME gave acceptable accuracy and precision for the quantification of AITC and related compounds in …
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Characterizing Ultrafast Equilibrium Dynamics Using Third-Order Nonlinear Mid-Infrared Spectroscopies
… complexes were compared to those detected by an isothiocyanate group with a different binding angle. Molecular dynamics simulations showed that intramolecular reorientation of azide sampled a larger space leading to faster orientational relaxation compared to isothiocyanate. The local environment …
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Synthesis of exo-affinity labeling agents of protein tyrosine phosphatase non-receptor type 1
… towards new derivatives of Tirapazamine. Allyl isothiocyanate (AITC) is a phytochemical that can be found in cruciferous vegetables and has received interest due to beneficial health effects. During our analyses of AITC towards inactivation of PTP1B we noticed the surprising absence of the …
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Surface Enhanced Raman Spectroscopy as a Tool for Waterborne Pathogen Testing
… dye molecules. The dye molecules, rhodamine B isothiocyanate (RBITC) and malachite green isothiocyanate (MGITC) were surface enhanced by the gold nanoparticles resulting in unique fingerprint SERS spectra. The SERS label method was successful in detecting G. lamblia and C. parvum …
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Dendrimer Modified Silica Nanoparticles as Fluorescent Chemosensors for the Detection of Copper and Cyanide Ions
… and platforms for the attachment of rhodamine isothiocyanate (RITC) or fluorescein isothiocyanate (FITC) fluorescent dyes. In the presence of Cu<sup>2+ </sup>ions, the emission of the fluorescent dye is quenched by Forster resonance energy transfer (FRET) and is dependent upon dendrimer …
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AN INVESTIGATION INTO THE ANALYTICAL UTILITY OF CHANGES IN POLARIZATION ACCOMPANYING ANALYTICAL DERIVATIZATION REACTIONS (FLUORESCENCE)
… between primary amines and fluorescein isothiocyanate were initially studied. Changes in polarization were observed upon conjugation for many of the amines primarily due to changes in fluorescence lifetime. This reaction was also studied in varying amounts of glycerol to judge the effect …
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Nanoscale Hydrogel Films and Polymer Brushes Grafted Onto Nanocapillary Array Membranes for Externally Controllable Size -Selective Molecular Transport
… fluorescence measurements using fluorescein isothiocyanate (FITC) labeled dextrans.
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Characterization and Analysis of Anti-Metatype Antibodies
… 4-4-20 affinity-labeled with fluorescein 5-isothiocyanate into rabbit elicited antibodies specific for the liganded conformation of 4-4-20. Termed anti-metatype antibodies, this polyclonal reagent also demonstrated the unique ability to delay the rate of dissociation of fluorescyl ligand …
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Synthesis, characterisation and biological activity of FITC-insulin for the development of an artificial pancreas
… of this thesis was to produce a fluorescein isothiocyanate (FITC)-insulin conjugatewhich shows equivalent biological activity to native insulin under novel reaction conditions without theneed for using protecting groups and multi-step synthetic conditions. Secondly, the stability …
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The synthesis and reactions of thienopyridines
… derivative (B; R = CN) also reacts with phenyl isothiocyanate to form thienopyridine (F; R = CN; X = NHPh). Reaction of the nitriles (A, C and D; R, R<sub>1</sub> = CN) under identical conditions, however, does not give the bicyclic compounds but ketene dithioacetals (I, J and K). Increasing the …
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Improving the Health Benefit of Broccoli by Maximizing Sulforaphane Formation: A Role for Epithiospecifier Protein
The isothiocyanate sulforaphane is a potent anticarcinogen derived from broccoli. For sulforaphane to be formed, fresh broccoli tissue must be crushed, allowing the myrosinase-catalyzed hydrolysis of the glucosinolate precursor, glucoraphanin. A common assumption has been that sulforaphane is the …
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SYNTHESIS, SURFACE MODIFICATION, AND CHARACTERIZATION OF BIOCOMPATIBLE MULTIFUNCTIONAL NANOPARTICLES
… derivative, TRITC-dextran (tetramethyl rhodamine isothiocyanate conjugated dextran), the hydrophilic dye, was loaded in MSNs through the water-in-oil microemulsion method, while, the hydrophobie dye, FITC (fluorescein isothiocyanate), was loaded in MSNs by using a sol-gel method. The FITC …
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The Role of Microbiota in Formation and Bioavailability of Sulforaphane From Glucoraphanin in F344 Rats
… evaluated in our study was nitrile, instead of isothiocyanate. This caused by decreased pH in media, known to favor nitrile formation, since microbiota in buffer did not alter this. The technical limitation of in vitro incubation studies may be that bacteria are sensitive to environmental …
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