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Showing 1 to 20 of 28 for “"isoquinoline"”.
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Isoquinoline alkaloids improve amino acid digestibility and intestinal function of pigs
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-04-06 without embargo terms
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I. A New Approach to the Isoquinoline System. Ii. Studies on Haplophytine
Made available in DSpace on 2014-12-05T19:37:08Z (GMT). No. of bitstreams: 1 5902043.pdf: 2199289 bytes, checksum: 07745a330b89e202a05e44b167261f27 (MD5) Previous issue date: 1959
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Synthesis and evaluation of quinoline-5,8-diones and isoquinoline-5,8-diones as anticancer agents
… class of functionalised quinoline-5,8-diones and isoquinoline-5,8-diones. The structured approach adopted is predicted to lead to advancements in the two frameworks, expanding the structural diversity of both the quinoline-5,8-diones and isoquinoline-5,8-diones families with bioactivity …
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Isoquinoline alkaloids in diets for young growing pigs improve nutrient digestibility and gut health
… were conducted to evaluate the effects of isoquinoline alkaloids (IQ) in corn-soybean meal (SBM) diets fed to young growing pigs on growth performance, gut health, energy and nutrient digestibility, and digestible energy (DE) and metabolizable energy (ME) concentrations in the diets. In the …
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Studies in stereoselective synthesis via reissert compound chemistry
Isoquinoline alkaloids have long been known for their biological activity. Many of the isoquinoline alkaloids have been made as racemic mixtures. The present investigation was aimed at developing methodology for the asymmetric synthesis of some isoquinoline alkaloids through Reissert compound …
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Synthesis of an activated difluorotetraketone monomer via Reissert chemistry
… routes entail preparation via a dibenzylic bis(isoquinoline) and a diketone bis(isoquinoline) system. These compounds were converted to their corresponding Reissert compounds. Reaction of the anion of the dibenzylic Reissert compound with p-fluorobenzaldehyde, followed by oxidation of both …
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Investigation of the phytochemistry and biological activity of isoquinoline alkaloids isolated from the South African medicinal plants, cyrtanthus sanguineus (Lindl.) walp. and cyrtanthus obliquus (L.f.)ait
The term "traditional medicine" refers to the ways of protecting and restoring health that existed before the arrival of modern medicine. These approaches to health belong to the traditions of each country and have been handed down from generatio to generation.
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Werner clathrates: structure and selectivity
… the inclusion compound. When the host Ni(NCS)₂(isoquinoline)₄ (H1) was exposed to xylene isomers the selectivity of the rigid isoquinoline ligand was investigated and compared to the more pliable 4-phenylpyridine. The flexibility of torsion angles in a range of pyridine derivative ligands was …
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Studies in the stereoselective synthesis of 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines
Isoquinoline alkaloids and analogs play an important role in today's pharmaceutical industry. The need to synthesize single stereoisomers of these alkaloids is important. Many times only a single stereoisomer exhibits the desired activity, while other stereoisomers of the alkaloid exhibit undesired …
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The 1,3-Diazabiphenylene system. synthesis, chemistry, and incorporation into a linearly extended purine analogue
… with acid in methanol, providing a substituted isoquinoline. Progress toward the synthesis of the dimensional probe, lin-bcb-adenine, incorporating the 1,3-diazabiphenylene skeleton, is summarized, and the synthesis of a pyrimido{6,5-i}imidazo{4,5-g}cinnoline, via a heteroaromatic cross coupling …
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The design and synthesis of mixed ligand metal organic frameworks for xylene inclusion
… 2-(pyridin-4-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (Lig3), 2-(pyridin-4-ylmethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (Lig4) and N,N'-bis(glycinyl)pyromellitic diimide (Lig5). The second part involves the synthesis and characterization of MOFs. The MOFs will be …
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New hydrogen bonding motifs for anion and neutral guest complexation
… for binding anions in DMSO solution. Also, isoquinoline based ligands form more stable complexes than pyridine based ligands and their extra rigidity preorganises the receptor for increased anion affinities. The heteroleptic receptor (trans-[Pt(isoquinoline-urea)2(pyridine)2](BF4)2) …
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<em>Ab Initio</em> Studies of High Temperature Pyrolysis Mechanisms in Heterocyclic Nitrogen-Containing Compounds.
… experimental work on pyridine, quinoline and isoquinoline shock-tube decomposition in light of new <em>ab initio</em> energy calculations using Gaussian 98. The pathways thus determined support the proposed pyrolysis mechanisms and agree with experimental evidence obtained from independent …
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CONTINUOUS-FLOW STRATEGIES FOR THE PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS AND RELEVANT INTERMEDIATES
… the oxidative functionalization of quinoline and isoquinoline derivatives, providing sustainable and reagent-efficient alternatives to traditional oxidative protocols. Finally, the applicability of the developed methodologies to real-world pharmaceutical processes is demonstrated through a …
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Synthesis of novel heterocyclic polymers via the chemistry of Reissert compounds
… exhibiting Tg of 190°C. Several novel bis-isoquinolines were prepared using an en amine reaction reported by Minter and Re.52 One of these bis-isoquinolines was used to prepare two novel bis-Reissert compounds which could be polymerized with several dialdehydes to obtain high molecular …
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Binding of Pixantrone with DNA Bulge Sequences
… pixantrone (6,9-bis[92- aminoethyl)amino]benzo[g]isoquinoline-5,10-dione fumarate) to the tridecanucleotide d(CCGAGAATTCCGG)2 that contains a single bulged adenine on each strand and the oligonucleotide duplex d(TACGATGAGTA) : d(TACCATCGTA), that contains a single bulge and a single 5’-CpG site, …
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Novel nitrogen containing polymers via Reissert chemistry
… nuclei which included benzothiazole, isoquinoline and quinoline. Acylated linear polyamine derivatives were obtained by the step growth condensation polymerization of open chain bis(Reissert compound)s with suitable dihaloalkanes; intrinsic viscosities of up to 0.48 dl/g were obtained …
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The preparation of heterocycles by [2+2+2] cyclization and inverse electron demand Dels-Alder reactions of arynes with 1,2,4-triazines
… were also investigated for the generation of isoquinoline core structures. The results showed that only triazines with electron withdrawing groups participated in the IEDDA reactions with benzyne as a partner after screening of several different arynes, which limited the scope of the reaction. …
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Enhancing the cooperative binding properties of1,1'-bis(1,2,3,4-tetrahydroisoquinolines)
The design of partially reduced 1,1'-bisisoquinoline derivatives was investigated with the aim of controlling the conformation about the C1-C1' axis. This would produce ligands with unusual but predictable ligand binding properties, particularly cooperativity. The introduction of ω-aminoalkyl, …
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Alteration of differentiation and growth of normal human epidermal keratinocytes by benzo[a]pyrene and arsenic
… (BaP), carbazole, dibenzothiophene, and isoquinoline] was investigated using the MTT assay; however, the research direction changed to focusing on examining the cellular effects, in NHEK, of BaP, the most toxic and carcinogenic polycyclic aromatic hydrocarbon among the four, and arsenic, …
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