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Showing 1 to 20 of 44 for “"isoproterenol"”.
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Kontraktilität des isolierten menschlichen Kardiomyozyten. Einfluß von Calcium, Isoproterenol, Stimulationsfrequenz, Stimulationspause und Thapsigargin.
Die kontraktile Funktion des Kardiomyozyten wird durch die Calciumhomöostase bestimmt und kann experimentell zusätzlich zur Kraft-Frequenz-Beziehung (KFB) anhand der Post-Pausen-Beziehung (PPB) untersucht werden. Während die KFB eher die Funktion des sarkoplasmatischen Retikulums (SR) prüft, …
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Investigations into the Actions of Vasopressin Histamine, Isoproterenol, Phentolamine, Phenylephrine, and Propronalol on Flow Through Perfused Rat Livers
The problem. The experiments were intended to elucidate any intrahepatic actions of the drugs employed as presinusoidal or postsinusoidal and to identify any antagonism of the drugs to others. Procedure. Livers were excised and perfused at a constant rate through the portal vein with different …
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Mechanismus der Hemmung der glucagon-stimulierten Phosphoenolpyruvat-Carboxykinase-1-Genexpression durch das proinflammatorische Interleukin 6 in primär kultivierten Rattenhepatozyten
… der wie Glucagon über cAMP wirkende ß-Agonist Isoproterenol eingesetzt werden sollte. In primär kultivierten Rattenhepatozyten stimulierten Glucagon und Isoproterenol den Anstieg der PCK1-mRNA. IL6 hemmte sowohl den durch Glucagon als auch den durch Isoproterenol stimulierten PCK1-mRNA-Anstieg. …
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Η ΕΠΙΔΡΑΣΙΣ ΤΗΣ ΙΣΟΠΡΟΤΕΡΕΝΟΛΗΣ Η ΤΗΣ ΜΥΟΚΑΡΔΙΑΚΗΣ ΙΣΧΑΙΜΙΑΣ ΕΠΙ ΤΟΥ ΜΑΓΝΗΣΙΟΥ ΤΟΥ ΜΥΟΚΑΡΔΙΟΥ ΕΠΙ ΥΠΑΣΒΕΣΤΙΑΙΜΙΑΣ: πειραματική μελέτη
… MAGNESIUM CHANGES AFTER ADMINISTRATION OF ISOPROTERENOL OR CORONARY ARTERY LIGATION DURING HYPOCALCAEMIA. WE USED 34 ANAESTHETISED DOGS (6 GROUPS) AND CONNECTED THEM WITH ARTIFICIAL KIDNEY. HYPOCALCAEMIA WAS ACHIEVED IN GROUPS B, D, F. INTRAVENOUS ISOPROTERENOL WAS GIVEN IN GROUPS C, D AND …
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Phenotypic characterization of stress Leukocytosis
… to acute psychological stress and β-agonist (isoproterenol) infusion. Chapter two showed that γδ T cells are mobilized in response to psychological stress and isoproterenol infusion, implicating β-adrenergic mechanisms in this response. Chapter three demonstrated that γδ T cells that were …
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FHL2 Inhibits Calcineurin and Represses Pathological Cardiac Hypertrophy
… to an exaggerated response to beta-agonist (isoproterenol)-induced cardiac hypertrophy. Isoproterenol-induced hypertrophy relies on activation of the calcineurin-NFAT pathway, and inhibition of calcineurin is sufficient to block growth in response to isoproterenol. I also observed that FHL2 …
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A Study of the Action of Prostaglandin F2a on the Guinea-Pig Isolated Trachea
… | Cumulative log dose-response curves to isoproterenol before and after either PGF2a or a beta blocker (MJ 1999) provided data for calculating and plotting both isoboles and Lineweaver-Burk curves. These, calculations indicated that PGF2a is not inhibitory to the action of isoproterenol on …
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Myocardial Contractility in Fetal Sheep Exposed to Long-term Hypoxia at High Altitude : Activator Calcium and Beta-adrenergic Receptor Function
… ryanodine (10<sup>-10</sup>-10<sup>-4</sup> M), isoproterenol (10<sup>-10</sup>-10<sup>-6 </sup>M), and forskolin (0.01-10 uM) in isometrically contracting papillary muscles. In addition, we quantified dihydropyridine (DHPR), ryanodine (RyR), and β-adrenergic receptor densities, and measured …
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Adrenergic-cholinergic interactions in the heart
… inhibit the positive inotropic responses to isoproterenol, a f3-adrenoceptor agonist, forskolin, a direct activator of adenylate cyclase, IBMX, a phosphodiesterase inhibitor, and phenylephrine, an a-adrenoceptor agonist. While the inhibitory effect of carbacholon the isoproterenol-stimulated …
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Reciprocal Relationships Between the Neuroendocrine System and Lymphoid Cells
… receptors while the (beta)-agonist, isoproterenol, prevents the mitogen-induced increase in (beta)-adrenoceptors. Both cortisol and isoproterenol increase the apparent dissociation constant of (beta)-adrenoceptors on concanavalin A-activated splenocytes, but this effect is …
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Effects of Senescence on Vascular Smooth Muscle in the Yellow Mud Turtle "Kinosternon flavescens" (Family "Kinosternidae")
… chloride, phenylephrine, acetylcholine, and isoproterenol to identify physiological responses in the vascular smooth muscle. No statistically significant changes in response related to aging were observed. Contractions were produced by acetylcholine, a feature typical of "Pseudemys scripta" …
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The Effects of 5-Fluorouracil on The Secretory Process of The Rat Parotid Gland (Protein)
… with either 5 mg/kg pilocarpine or 5 mg/kg isoproterenol in experimental, pair-fed, and control animals. Saliva from experimental animals was significantly lower in volume, amylase and protein content than both control groups. Sodium dodecyl sulfate, anionic and cationic gel electrophoresis …
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High throughput optical sensor arrays for drug screening
… cellular activity, the cells were exposed to Isoproterenol and Forskolin, which are known to elicit intracellular cyclic AMP production. The assay proved robust in detecting long term drug induced extracellular potassium flux. Ion flux magnitude was used to generate EC50 values of 1.185 nM and …
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Intracellular calcium mobilization in cardiomyocytes of rats with experimental diabetes
… and relengthening (±dlidt), and response to isoproterenol stimulation were significantly depressed in diabetic cells. These reflect similar features presented in intact diabetic heart and cardiac tissues. The sarcoplasmic reticulum (SR) Ca2+ content assessed by rapid cooling contracture …
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Compound 49b: A Novel Beta-Adrenergic Receptor Agonist in the Treatment of Diabetic Retinopathy
… a non-specific beta-adrenergic receptor agonist, isoproterenol, was effective in preventing functional and morphological changes associated with diabetic retinopathy in the rat. Isoproterenol also produced left ventricle remodeling suggesting it entered the systemic circulation. We therefore …
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Mechanisms of Control of Blood Flow in the Forelimb of Sheep
… the mechanisms of norepinephrine, epinephrine, isoproterenol, and acetylcholine.</p> <p>First, in a constant pressure/variable flow preparation we characterized the sheep brachial artery blood flow response to, and recovery from, 10-min infusions of each of these drugs. Then we used a computer …
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Effect of Long-Term Hypoxia on Myocardial Alpha1- Receptors
… stimulation produced greater response to isoproterenol stimulation {maximal tension developed (Tmax, g/mm<sup>2</sup> =: 1.16 ± 0.18)}; than normoxic left ventricle without prior phenylephrine stimulation {maximal tension developed (Tmax, g/mm<sup>2</sup> =: 0.41 ± 0.05)} (p<0.01). …
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Pharmacodynamic evaluation of beta-blockade associated with atenolol in healthy dogs
… atenolol attenuates the heart rate response to isoproterenol for 24 hours, we performed a double-blind, randomized, placebo-controlled cross-over experiment. Animals: Twenty healthy dogs Procedures: Dogs were randomly assigned to receive either placebo (P) and then atenolol (A), [1 mg/kg PO …
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The Function Of Sarcoplasmic Reticulum In The Aged Rat Heart
… heart, {dollar}beta{dollar}-adrenergic agonist isoproterenol-stimulated peak inotropic and lusitropic responses were significantly reduced with aging. Under similar conditions, isoproterenol (0.1 {dollar}mu{dollar}M)-stimulated phosphorylation of phospholamban in situ was significantly …
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