Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"isoprostanes"”.
-
Regulation of Endogenous Excitatory Neurotransmitters by Isoprostanes
We have evidence that isoprostanes (IsoPs) regulate exogenously applied excitatory amino acid neurotransmitter glutamate in bovine retina, in vitro. However, the regulation of retinal endogenous glutamateby IsoPs is unknown. The objective of the present study was to investigate the effect of …
-
Can isoprostanes be used to predict survival in horses with colic?
… year. The outcome is fatal in 11% of cases. F2-isoprostanes are the "gold standard" for assessment of oxidative stress in vivo and have been used extensively to quantify lipid peroxidation in association with risk factors in various diseases in humans. Because horses with colic may have …
-
F₂-isoprostanes study after exposure to selected nanoparticles by liquid chromatography/tandem mass spectrometry and investigation of nanoparticles on the cytotoxicity effect of arsenic in vitro
… in human lung epithelial cells (A549). F₂-isoprostanes are novel reliable biomarkers for lipid peroxidation. In the first part of this work, total free F₂-isoprostanes were quantified by high performance liquid chromatography/mass spectrometry followed by the exposure of SiO₂ (15 nm), CeO₂ …
-
Differential effects of fatty acids on the endothelium
… insulin, nitric oxide metabolites (NOx) and isoprostanes. The same measurements were made at the study endpoint, 6 weeks. An in vitro investigation of the effects of physiologically-relevant fatty acid profiles on microvascular endothelial cell nitric oxide and prostacyclin production was …
-
The Effects of Mitochondria-targeted Antioxidant Supplementation on the Adaptive Response to Exercise, Athletic Performance, and Recovery
… of exercise-induced increases in plasma F2-isoprostanes, which are a systemic marker of lipid peroxidation. Chapter 5 investigated the effect of MitoQ supplementation on recovery of muscle function following a bout of eccentric exercise involving the knee extensors in young, untrained men. …
-
Biomarkers of oxidative stress and inflammation in biological samples collected from recurrent airway obstruction (RAO)-affected horses and their controls
… of biological samples. Concentrations of 8-isoprostanes, isofurans, amino acids and mRNA expression of interleukin 4 (IL4), gamma interferon (INFγ), inducible nitric oxide synthase (iNOS), extracellular glutathione peroxidase (GPx-3), and cytosolic superoxide dismutase (SOD-1) were not …
-
Strategies towards the synthesis of prostaglandin analogues
… a late-stage intermediate for the synthesis of isoprostanes. Methodologies to perform cis-hydroxylation followed by oxidative cleavage of the cyclohexene moiety have been successfully implemented. Finally, a synthesis was designed for generating oxygen analogues of the prostaglandin targets.
-
Physicochemical and Sensory Properties of Resistant Starch-Based Cereal Products and Effects on Glycemic and Oxidative Stress Responses in Hispanic Women
… parameters (cellular glutathione peroxidase, F2- isoprostanes, and oxygen radical absorbance capacity) in Hispanic women (n=9). Granola bars and cereals were developed to provide 2 levels (10% and 15%) of RS; isocaloric (0% RS) control samples were prepared with readily digestible (high …
-
The effects of two modes of exercise training on plasma biomarkers of inflammation and oxidative stress in patients with symptomatic peripheral artery disease
… groups showed non-significant decreases in F2 Isoprostanes. Additionally there was no significant correlation between baseline plasma inflammatory and oxidative stress biomarkers, with physical and physiological variables such as ankle-brachial index, pain-free walking distance, and maximal …
-
EVALUATION OF THE OXIDATIVE METABOLITES OF ARACHIDONIC ACID AND THEIR IMPLICATION IN THE PROGRESSION OF INFLAMMATORY DISEASES: HYPERTENSION AND RHEUMATOID ARTHRITIS
… acids (EETs), prostaglandins (PGs), isoprostanes (Isops) and thromboxanes (TXs). It is our hypothesis that AA metabolites will help in understanding the progression of inflammatory diseases. To confirm this hypothesis, analytical methods including HPLC-UV and LC-MS were developed. The …
-
Molecular analysis of the role of mitochondria in aging and lengevity
The Free Radical Theory of Aging states that there is an increase in reactive oxygen species (ROS) production with aging leading to increase in tissue dysfunction. Mitochondria are the major source of ROS, which damages essential macromolecules by oxidative modification and may lead to …
-
Phytoprostane F1
Isoprostane F2 sind Autoxidationsprodukte der Arachidonsäure, die über radikal-katalysierte Oxidation entstehen. Bei einigen Erkrankungen im Tier konnte gezeigt werden, daß die Konzentration von Isoprostanen F2 mit dem verstärkten Vorkommen von freien Radikalen korreliert, weshalb Isoprostane heute …
-
Nitrates and Left Ventricular Dysfunction
Use of beta-blockers and inhibitors of the renin angiotensin system (RAS) is established practice in the treatment of chronic heart failure (CHF). Clinical studies also suggest beneficial long-term effects of nitrates in CHF. In the Veterans Administration Heart Failure Trial (V-HeFT) I, the …