Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"isoprenoids"”.
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Engineering a novel pathway for isoprenoid synthesis
Isoprenoids comprise a large class of chemicals, of significant interest due to their diverse properties. Most isoprenoids are plant secondary metabolites and are of commercial importance due to their varied applications in fields spanning medicine, agriculture, flavors, fragrances, cosmetics and …
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Mechanism, inhibition and spectroscopy of isoprenoid biosynthesis enzymes
Isoprenoids (or terpenes) are a large class of compounds with great physiological importance in all kingdoms of life. The research in this work explored the mechanism and inhibition of several enzymes in two important pathways for isoprenoid biosynthesis. The first pair of enzyme are IspG and IspH, …
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Discovery of Enzymes Responsible for an Alternate Mevalonate Pathway in Haloferax volcanii
… domain of microorganisms that contain isoprenoids in ether linkages to glycerol rather than the ester linked fatty acids that characterize membranes of bacteria or eukaryotes. Radiolabeling experiments with acetate and mevalonate strongly implicate the mevalonate pathway in providing …
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Structural insights into conformationally-gated reactions catalyzed by thiamine pyrophosphate-dependent enzymes
… or G3P) into DXP, an essential precursor of isoprenoids, vitamin B1, and vitamin B6 (pyridoxal phosphate, PLP) in bacterial pathogens. Human adapts different pathways to access those essential metabolites; thus, selective inhibition of DXP synthase has been considered to be a possible …
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Stable isotope and organic biomarker analysis of the late Proterozoic Coppercap formation in the MacKenzie Mountains
… the Cryogenian glacial episodes. Based on aryl isoprenoids, n-propyl cholestane, isopropyl cholestane, total organic carbon, carbonate mineral analysis, [delta]34S from pyrite, [delta]13Corganic and [delta]13Ccarbonate values, environmental conditions of the Coppercap Formation were …
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Approaches to understanding diversity in rubber and carotenoid synthesis in <i>Hevea brasiliensis </i>latex
… of natural rubber. Rubber and other non-rubber isoprenoids in <i>Hevea </i>latex are synthesised from isopentenyl diphosphate (IPP) generated from the cytoplasmic mevalonate (MVA) pathway and the plastidic methyl erythritol phosphate pathway (MEP). This study utilised two rubber tree clones …
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Yeast engineering for pharmaceutical and nutraceutical purposes
… was expanded to both accumulative and diffusible isoprenoids, which are synthesized from cytosolic acetyl-CoA. The elimination of allosteric up-regulation on phosphofructokinase and consequently upper glycolysis down-regulation could be achieved by mutagenesis on PFK1 and PFK2 or deletion of PFK26 …
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Interactions of the Terrestrial Biosphere With Climate and Atmospheric Chemistry
Isoprenoids are the most dominant class of biogenic volatile organic compounds (BVOCs) and have been shown to significantly impact global tropospheric chemistry and composition, climate and the global carbon cycle. In the second part of this dissertation, the sensitivity of biogenic isoprene and …
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Isolation and Characterization of an Isoprenoid Transporter Protein in Manduca sexta
… locations to ensure proper cell function. Isoprenoids are metabolite molecules implicated in cell growth, energy production, and act as precursor to steroids, cholesterol, and other derived compounds in living organisms. Within the isoprenoid pathway, isopentenyl pyrophosphate (IPP) was …
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Hydrocarbon biomarkers for biotic and environmental evolution through the Neoproterozoic-Cambrian transition
… specific carbon isotopic data of n-alkanes and isoprenoids were also acquired and evaluated in the context of existing datasets with a focus on elucidating the processes responsible for anomalous trends. Consistent with current theory, our results indicate that there was a significant shift in …
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Molecular cloning, characterization, and expression of 3-hydroxy-3-methylglutaryl coenzyme a reductase gene from tomato
… defense compounds, and numerous other isoprenoids. To initiate molecular studies of HMGR in relation to defense responses in plants, we utilized yeast HMGR cDNA sequences to isolate tomato genomic sequences encoding HMGR. The nucleic acid sequence and gene structure was determined. The …
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SYNTHESIS OF NATURAL-DERIVED POLYPHENOLS AS POTENTIAL ANTICANCER AGENTS
… main families of secondary metabolites include isoprenoids, polyketides, alkaloids, non ribosomial peptides and polyphenols, these latter directly derived from shikimate pathway, as phenylpropanoids and lignans, or from a mixed biosynthetic pathway (shikimate/ acetate and/or malonate pathways), …
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Preservation Potential of Permian Gypsum Beds, Nippewalla Group, USA
… hopanes, methyl-hopanes, nor-hopanes, and isoprenoids, pristane and phytane, mostly within the gypsum. The presence of these biomarkers indicate that they can be preserved in oxidizing conditions, at least in the presence of gypsum, as it is likely the key factor to the biomarkers …
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The Role of High-Density Lipoproteins and Related Pathways in Alzheimer’s Disease
… lipid modification process that attaches isoprenoids (the intermediates in the cholesterol biosynthesis pathway) to target proteins. Electrophysiological/histochemical experiments showed that systemic or forebrain-specific deficiency of one particular prenyltransferase, …
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Understanding and Harnessing the Structural Features that Govern HMG-CoA Reductase Activity
… routes to producing the building blocks for isoprenoids, which represent the largest and most diverse class of natural products. Natural products and its derivatives continue to provide important compounds in the fields of drug development, biomedical engineering, and commercially-driven …
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Mechanisms of bacterial polyprenyl transferases and multi-target drug discovery for tuberculosis
… subtilis and is predicted to produce C30 isoprenoids. We determined the structure of YisP, and proved that YisP acts as a phosphatase. Using DSC, we confirmed that farnesol shift and broaden the gel-to-liquid crystal transition of lipids. The X-ray structure of the bacterial diterpene …
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Investigating the importance of different sources of organic matter as food for the benthos on three Arctic shelves
… interior shelves, respectively. Highly branched isoprenoids – lipid biomarkers<br/>produced with distinct structures in sea ice and the water column – were used to calculate<br/>the ratio of sympagic-to-pelagic organic matter assimilated by the benthos in the Barents Sea<br/>and Northeast …
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Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation
… intracellular signaling. We showed that isoprenoids are essential for activated Treg-cell suppressive activity, and Treg cell-specific deletion of the enzymes that mediate farnesylation and geranylgeranylation (encoded by Fntb and Pggt1b, respectively) leads to a reduction of eTreg cells …
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