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Showing 1 to 4 of 4 for “"isomalabaricane"”.
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Approaches to the synthesis of stelliferin, a marine isomalabaricane triterpene
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Total synthesis of 19,20-epoxydocosapentaenoic acid-ethanolamide (19,20-EDP-EA) and strategies towards the total synthesis of malabaricane triterpenoids
… investigation into a synthetic route towards the isomalabaricanes. Here we describe our attempts at synthesizing the malabaricane core first from an isomalabaricane intermediate via a divergent strategy and later through a more general approach featuring a one-step construction of tricycle from …
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Total synthesis of marine terpenoids
… full account of our synthetic endeavors towards isomalabaricane triterpenoids, natural products discovered 40 years ago in marine sponges of genera Stelleta, Jaspis, Rhabdastrella, and Geodia. Studies showed that these molecules possess valuable biological properties, such as high cytotoxicity, …
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Studies of Bioactive Natural Products and Mechanism-Based Bioassays
… with DNA polymerase β. From this extract, four isomalabaricane triterpenoids were isolated and characterized, three of which were active in the binding assay. All compounds were active in the A2780 ovarian cancer cell line assay. Bioassay-guided fractionation of an extract of a sponge of species …