Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 855 for “"isoforms"”.
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Discovering the p53 isoforms’ code
… TP53 gene physiologically expresses several p53 isoforms, challenges this paradigm. According to the data gathered about p53 isoforms in the past ten years, we hypothesise that the so-called p53 is a multi-protein system composed by the twelve isoforms and that a p53-mediated cell response is, in …
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Caspase isoforms in inflammasome activation
Inflammasomes are macromolecular signalling platforms composed of a receptor (for example NLRP3 or NLRC4), an adaptor (ASC) and effectors (caspases) that are thought to play critical roles in the host defence against microbial infections. Activation of inflammasomes leads to the processing of the …
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Expression and glycosylation of meprin isoforms
Meprin A and meprin B are disulfide-linked, oligomeric metalloendopeptidases in renal brush border membranes. Meprin A contains 90-kDa subunits (α subunits) and is expressed in random-bred and some inbred strains of mice. Meprin B contains subunits of 110 kDa (β subunits) <i>in situ</i>, and the …
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Characterization of Peripherin Isoforms in Amyotrophic Lateral Sclerosis
… of basic IF biology and the role of peripherin isoforms in injury and in motor neuron disease.
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NF-YA ISOFORMS ROLES IN CLAUDIN LOW CANCERS
… leukemia cancers. NF-YA is present in two major isoforms called NF-YAl (long), and NF-YAs (short), which alternative splice exon 3. NF-YAl/NF-YAs ratio changes in different tissues, cell lines and differentiational stages. A robust increase in mRNA levels of NF- YA has been observed in different …
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The role of GATA-1 isoforms in haematopoiesis
… choices. GATA-1 produces at least two protein isoforms – the well characterised GATA-1 full-length (GATA-1FL) isoform and a truncated isoform – GATA-1 short (GATA-1s). GATA-1FL comprises two conserved Zinc fingers (which interact with DNA and essential co-factors), a C-terminal tail (of mostly …
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Protein kinases that phosphorylate 14-3-3 isoforms
… synthesis. The 14 -3 -3 family consists of 7 isoforms (denoted a, ß, y, 8, c, rl and in mammals and shows a degree of isoform specificity in binding target proteins. 14 -3 -3 is phosphorylated in an isoform specific manner, for example SDK1 /PKD phosphorylates 14 -3 -3 11,13 and (, but not cs …
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The FP prostanoid receptor: Isoforms and functional studies
… other prostanoid receptors, we hypothesized that isoforms, or alternative splice variants of the FP receptor that differed in their functional coupling might exist. Using a corpus luteum library, we cloned a novel, truncated form of the FP prostanoid receptor, known as the FP(B) receptor isoform. …
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Analysis of multiple calmodulin isoforms in Arabidopsis thaliana
… which binds four calcium ions. Three calmodulin isoforms have previously been characterized in Arabidopsis thaliana, and in this study three additional cDNA sequences encoding calmodulin isoforms have been isolated. These sequences (ACaM-4, -5, and -6) represent members of the Arabidopsis …
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Systematic Identification of Interaction Partners of RET Receptor Isoforms
… of the RET gene produces two conserved protein isoforms, RET9 and RET51, that differ in their subcellular localization and protein trafficking, and their functional roles in tumorigenesis and metastatic processes, suggesting that they may also differ in their interactomes. We used a combination …
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A study of rat skeletal muscle Troponin C isoforms
… for studying mammalian skeletal muscle) TnC isoforms on SDS gels. Therefore, a method was devised for unambiguous identification of TnC isoforms in rat single muscle fibres. This method, validated using rat skeletal muscle TnC isoforms purified for the first time as part of this study, was …
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Bst2 Isoforms: Distribution and Potential Use In Cancer Therapeutics
… Two research groups identified different BST2 isoforms of BST2 generated by posttranscriptional modification. In this research, I studied the long BST2 isoform’s distribution in breast tissue and B cell lines using the novel monoclonal antibody (MAb) LA5, an anti-BST2-long MAb. This approach …
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Probing Isoforms of the Prion Protein through Tyrosine Nitration
The prion protein (PrP) has multiple stable isoforms. When PrP misfolds, it aggregates and causes neurological disease and death in mammals. The structure of the non-pathogenic isoform has been determined while the structures of the disease related isoforms are unknown. The nitration labeling …
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Probing Isoforms of the Prion Protein through Tyrosine Nitration
The prion protein (PrP) has multiple stable isoforms. When PrP misfolds, it aggregates and causes neurological disease and death in mammals. The structure of the non-pathogenic isoform has been determined while the structures of the disease related isoforms are unknown. The nitration labeling …
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Role of Cyclooxygenase Isoforms in Peripheral Neuropathic Pain Model
… neuropathic pain. We investigated whether COX isoforms, rate-limiting enzymes that synthesize the prostaglandins, were involved in the pain behavior of spinal nerve-ligated rats. After ligation of left L5 spinal nerve in anesthetized rats, the foot withdrawal thresholds to mechanical stimuli …
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Fibronectin splice isoforms in wound healing and vascular development
… differentiation and survival. Different isoforms of fibronectin arise via alternative splicing of the transcript of a single gene. Although many of the general functions of fibronectins have been elucidated, few specific functions of the alternatively spliced isoforms have been described. …
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Probing Structural Differences of Recombinant Prion Isoforms Using Fluorescence Spectroscopy
… and refolded into PrPC or two misfolded isoforms of prion, PrPb and PrPF. Solvent accessibilities of the six tryptophan residues were probed among the three isoforms using various tryptophan fluorescence techniques. For all six mutants, solvent accessibility was shown to decrease …
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Probing Structural Differences of Recombinant Prion Isoforms Using Fluorescence Spectroscopy
… and refolded into PrPC or two misfolded isoforms of prion, PrPb and PrPF. Solvent accessibilities of the six tryptophan residues were probed among the three isoforms using various tryptophan fluorescence techniques. For all six mutants, solvent accessibility was shown to decrease …
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