Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"isoform-specific inhibition"”.
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Probing Orthologue and Isoform Specific Inhibition of Kinases using In Silico Strategies: Perspectives for Improved Drug Design
… exploitability for therapeutic design with high specificity essential for the advancement of novel drug strategies. In silico approaches have become increasingly prevalent for providing useful insight into protein structure-function relationships, offering new information to researchers about …
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The Study of Nitric Oxide Synthase Expression, Function, and Regulation in the Renal Vasculature During Postnatal Renal Development
… the immature kidney, nitric oxide synthase (NOS) isoforms, specifically eNOS and nNOS, are developmentally regulated, but their specific role and regulation are unknown.</p> <p>The enhanced vasodilatory role of NO in the immature kidney was hypothesized to be attributed to regulatory, …
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Biochemical and structural characterization of Sirtuins from mammals and Thermotoga maritima
… characterization of several mammalian Sirtuin isoforms, with main emphasis on the largest member of the family, Sirt1.Analysis of various Sirt1 constructs using analytical ultracentrifugation and electron microscopy techniques identified it to be a monomer, similar to other mammalian isoforms. …
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Actions of Pi3K-Delta Inhibitor, Idelalisib, and Its Combination With Bendamustine In Chronic Lymphocytic Leukemia
<p>Class I phosphatidylinositol 3-kinase isoforms (α, β, δ, and γ) play a major role in cancer cell growth and survival. PI3K α and β are most studied. PI3K pathway is highly dysregulated in many cancers and aberrant PI3K signaling is associated with oncogene mutations and disease progression in …