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Showing 1 to 20 of 47 for “"isoform expression"”.
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Software for Estimation of Human Transcriptome Isoform Expression Using RNA-Seq Data
… capable of handling multireads and quantifying isoforms on a more global level. Current software available for these purposes uses various forms of parameter alteration in order to work with multireads. Many still analyze isoforms per gene or per researcher determined clusters as well. By doing …
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Deconvoluting Cell-Type Specific 3'UTR Isoform Expression in the Adult and Developing Cerebellum
… show that miR-124 specifically targets the long isoform of Memo1, which provides a mechanism for its downregulation during development. Our findings give insight into the roles for alternative polyadenylation in specific cell types and developmental stages, and help establish a platform for …
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Differential Na+/K+ Pump Isoform Expression in Higher and Lower Brain Regions of the Mouse
… Our laboratory has proposed that differential expression of Na+/K+-ATPase isoforms, the ion pumps responsible for maintaining the electrochemical gradients of neurons, may underlie this phenomenon. Specifically, the α3 isoform, but not the α1 isoform, possesses kinetic properties that allow it …
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A study of the role of glycogen in skeletal muscle performance and of myosin heavy chain isoform expression in amphibian skeletal muscle using the toad Bufo marinus
… muscle performance and the other with the MHC isoform composition in amphibian skeletal muscle and single muscle fibres. The organism used throughout this study was the cane toad Bufo marinus.
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Isoform-Specific Variant and Expression Analysis of Epigenetic Genes in Neurodevelopment and Disease
Isoform-Specific Genetic Analysis of Epigenetic Machinery Genes in Neurodevelopment and Disease Úlfur Benedikt Fjölnisson¹, Katrín Möller¹, Hans Tómas Björnsson¹,²,³ ¹ Department of Medicine, University of Iceland, Reykjavík, Iceland ² Johns Hopkins University, Baltimore, USA ³ University Hospital, …
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Expression and Regulation of Human Cytochrome P450 4F Isoforms In Tissue Samples and Under Tnf-Alpha Challenges
… the inflamed tissue environment may affect the expression of CYP4Fs during the pro-inflammatory state, which in turn may modulate inflammatory conditions during the anti-inflammatory state. We demonstrated that inflamed tissues have different levels of CYP4F isoform expression profiles in a …
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A TALE OF TWO NEUREXINS: NRX-1 AND NLR-1 FACILITATE FUNCTION OF MONOAMINE CIRCUITS AND FORAGING BEHAVIORS
… behavioral response to food deprivation in an isoform-specific manner, with the short γ-isoform of nrx-1 controlling the initiation/early responses to food deprivation in part via octopamine signaling. Meanwhile the long α-isoform controls the maintenance response to food deprivation with an …
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Characterization of Peripherin Isoforms in Amyotrophic Lateral Sclerosis
… this protein as a constitutively expressed isoform, termed Per-45, that arises from alternative translation and that is required for normal filament assembly: changes to the normal isoform expression pattern are associated with malformed filaments and intracellular inclusions. In lieu of the …
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Épissage alternatif et mutations ponctuelles de Pax5 chez la leucémie lymphoîde chronique et les lymphomes de cellules B
… (BSAP), possesses oncogenic properties and its expression is often deregulated in certain cases of B-cell malignancies such as non-Hodgkin lymphoma and acute lyrnphoblastic leukemia. Recent studies have revealed that the Pax5 transcript is subject to alternative splicing, thus producing multiple …
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The developmental liver transcriptome of Rattus norvegicus
… stages. We investigated such areas as gene expression, isoform expression, transcriptional regulation, and post-transcriptional modifications of transcribed molecules. Furthermore, we used a bioinformatics approach to improve upon the reference annotation for known genes. Our research gives …
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Proteomic Profiling of Animal Models of Motor Neuron Disease and Muscular Dystrophy
… are highly suitable to determine changes in the isoform expression pattern of muscle and testis proteins. The work presented outlines major categories of protein families that have been identified by proteomicsQbased screening approaches in conjunction with biochemical verification analyses. This …
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Mechanism and Function of TrkB.T1 Astrocyte Expression
… and mature brain. TrkB has two predominant isoforms expressed in central nervous system (CNS), the full length TrkB (TrkB.FL) receptor and truncated TrkB (TrkB.T1) receptor. We recently demonstrated in the adult rodent cortex that TrkB.T1 is largely specific to astrocytes and over 90% of all …
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The Na/K-ATPase in the gills of Antarctic and New Zealand nototheniids: The Physiologic and Molecular Effects of Warm-acclimation.
… of two subunits; a catalytic a-subunit with 4 isoforms and a |3-subunit with 3 isoforms. In previous teleost studies, several isoform mRNAs and al and a3 proteins have been identified in gills. As a first step towards quantifying the Na/K-ATPase a-subunit, we determined the mRNA and protein …
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Polyaseeker: a computational framework for identifying polyadenylation cleavage site from RNA-seq
… PolyASeeker and annotated by PolyA DB, special isoform expression patterns among tissues are found. Genes that have a specific 3'UTR expression have also been recognized in the brain. PolyASeeker is also run on an mRNA 3' UTR sequencing dataset and it is found that the software could be quite …
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Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
… breast tumors and breast cancer cell lines. Net1 isoform expression is also required for migration and invasion of breast cancer cells in vitro. These data indicate that Net1 may be a critical regulator of metastatic progression in breast cancer. Net1 activity is negatively regulated by …
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INVESTIGATING ALTERNATIVE SPLICING REPROGRAMMING REGULATED BY THE E-CADHERIN/B-CATENIN AXIS
… carefully regulated, producing the myosin VIlong isoform involved in endocytic functions. However, in epithelial tumors like colorectal adenocarcinoma (COAD), aberrant splicing leads to the expression of the myosin VIshort isoform, promoting tumor-cell migration. Using the Caco-2 cell line, …
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Thick filament regulation of myocardial contraction
… of sarcomere length and thick filament protein isoform expression on the contractile properties of single skinned cardiac myocytes. Myosin binding protein-C ablation (MyBP-C-\-) increases the rate of force development, loaded shortening velocity, and power output in mouse skinned cardiac …
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Proteomic Profiling of Animal Models of Myotonia and Motor Neuron Disease
… is highly suitable to determine change in the isoform expression pattern of muscle proteins. Identified proteins can be used as potential factors for the establishment of comprehensive biomarker signature of myotonic and motor neuron diseases.
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Alternative isoform regulation in myotonic dystrophy
… widespread deleterious changes in transcriptome isoform usage. We developed a method for studying transcriptomes, RNAseq, which provides a high resolution, digital inventory of gene and isoform expression. By applying RNAseq to human tissues and cell lines, we discovered that essentially 92-94% …
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The Role of Sulfatide in Alzheimer's Disease
… domains were not altered and no change in isoform expression was observed. Based on these findings, membrane organization does not appear to be altered in AD. It is important to note, however, that sodium channel clusters are restricted to a specific region of the axon and thus membrane …
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