Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"isoflurane"”.
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Isoflurane : interaction with hepatic microsomal enzymes
… in rat hepatic microsomes. The interaction of isoflurane with cytochrome P-450 results in its metabolism to fluoride ion and organofluorine metabolites. The cytochrome P-450 isozymes catalysing the defluorination of isoflurane were assessed in hepatic microsomes from phenobarbital-, …
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Limiting Exposure to Isoflurane in a Veterinary Occupational Setting
<p>This paper characterizes the veterinary occupational health hazards of waste anesthesia gas. A needs assessment was conducted to develop educational materials on hazard and control. Rcommendations were made to HESIS on need for educational products.</p>
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In vitro Microdialysis Sampling Collection of Volatile Organic Compounds (VOC's), Dodecafluoropentane (DDFP) and Isoflurane
… can collect volatile organic compounds, isoflurane (a standard inhalation anesthetic) and DDFP. Different perfusion fluids and flow rates were tested for optimal analyte collection through the microdialysis membrane. Instead of utilizing an aqueous perfusion fluid safflower oil and air …
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Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model
… aim of this study was to assess the effect of isoflurane post-treatment on intracranial hemorrhage and cerebral infarction after tPA treatment for transient cerebral ischemia. Cerebral ischemia was modeled in male Sprague-Dawley rats (n = 32) by occluding the right middle cerebral artery for 1 …
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Isoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway
… We investigated the cardioprotective effects of isoflurane administered at the onset of reperfusion in senescent rat in vivo, and the activation of the reperfusion injury salvage kinase (RISK) pathway to address a possible mechanism underlying age-related differences. METHODS AND RESULTS: Male …
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The Effect of General Anaesthesia on Circadian Rhythms in Mice
… halogenated inhalational anaesthetic agents (isoflurane and sevoflurane), administered at different times of the day (circadian times, CTs), over a period of 24 hours. To do so, I collected data to construct a full phase response curve (PRC) for each anaesthetic agent. Animals received either …
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Comparative effects of halothane, isoflurane, and enflurane on the hemodynamics of newborn and older pigs using ascorbic acid dilution to measure cardiac output
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Disbudding of dairy goat kids: Refining protocols to reduce or eliminate pain
… method evaluated in this thesis, the effect of isoflurane and meloxicam on pain associated with cautery disbudding was investigated. Goat kids disbudded under isoflurane, with or without meloxicam, had lower cortisol concentrations and displayed fewer head-directed behaviours than goat kids that …
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The influence of anesthesia and nicotine on dopamine signaling in the rat dorsal striatum
… signaling in the brain. Although urethane and isoflurane anesthetics are commonly used in in vivo studies, isoflurane’s potential influence on dopamine signaling has not been thoroughly investigated. In addition to this, the addictive nature of nicotine indicates the importance of understanding …
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Cardiovascular effects of a low and a high dose of fentanyl in the isoflurane anesthetized dog: the influence of the anesthetic-sparing effect and the correction of bradycardia
… function in dogs anesthetized with isoflurane. In previous literature, a high dose of fentanyl improved cardiovascular function in enflurane anesthetized dogs only following correction of bradycardia associated with its use. The objective of this study was to evaluate the effect of …
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Hemodynamic Changes after Endotracheal Iintubation with a Lightwand or a Laryngoscope in Patients with Cerebral Aneurysm
… mg/kg). The lungs were ventilated with 3% isoflurane in oxygen. 1% lidocaine(1 mg/kg) were administered 90 seconds before the intubation. Patients were then intubated with either the lightwand or the laryngoscope when end expiratory isoflurane concentration 2 vol% and BIS less than 40. Room …
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Shedding Light On General Anesthesia: Uncovering The Molecular Mechanisms For Propofol And Volatile Anesthetics
… volatile anesthetics sevoflurane and isoflurane, as well as the most commonly used intravenous anesthetic, propofol. A novel photoaffinity ligand for sevoflurane was validated and applied to uncover the unique mechanism of sevoflurane positive modulation of mammalian Shaker Kv1.2 …
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Controlled cross circulation: effects on donor hemodynamics
… maintained in the donor dog with 1.8% end-tidal isoflurane. Parameters before and after controlled cross circulation were compared using a Wilcoxon Signed Rank Test. Donor left ventricular dP/dt max, pulmonary capillary wedge pressure, blood volume, systemic vascular resistance, heart rate, total …
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Gas exchange with a reflecting system for inhalational anaesthesia
… for administering the inhalational agents isoflurane and sevoflurane as an alternative to low-flow anaesthesia systems. It can also be used in intensive care units to administer sedation using isoflurane or sevoflurane to critically ill patients. The thesis is based on four papers. In paper …
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Validation of a new method of determining cardiac output in neonatal foals
… We compared this method to thermodilution in isoflurane anesthetized, 30 to 42 hour old foals and found good agreement (mean bias 0.0474L/min; limits of agreement -3.03 to 3.12) between the two methods in a range of cardiac outputs from 5.4 to 20.4 liters/min. The lithium dilution technique is …
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Untersuchungen zur künstlichen Beatmung bei der Maus (Mus musculus) mit dem UNO Micro-Ventilator®
… (MMF). With the beginning of the anesthesia with isoflurane (the concentration of the isoflurane is 2.7 vol.-%) the injectable anesthesia is antagonized with atipamezol, flumazenil, naloxone (AFN). The anesthesia lasts 100 minutes. The A. carotis of all ventilated animals is canulated in order to …
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AVALIAÇÃO DA ANALGESIA TRANS E PÓS-OPERATÓRIA DA NALBUFINA EPIDURAL EM GATAS
… dioxide (ETCO2) and expired concentration of isoflurane (ETISO) on transoperative periods. For the evaluation on postoperative period we used the multidimensional scale from UNESP-Botucatu to measure the postoperative acute pain in feline. The obtained data were analysed by ANOVA followed by …
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Evaluation of epidural morphine and incisional bupivacaine for analgesia following hemilaminectomy in the dog
… protocol and were anesthetized with propofol and isoflurane. After surgery, scores were assigned using a visual analog scale (VAS) for both pain and sedation and a composite pain scale (CPS). In addition, a von Frey anesthesiometer was used to determine pain thresholds at 1 cm and 3 cm from the …
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