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Showing 1 to 20 of 33 for “"isocitrate dehydrogenase"”.

  1. The Contextual Roles of Isocitrate Dehydrogenase-1 and Isocitrate Dehydrogenase-2 in Electron Transport Chain Complex III Deficiency

    Harris, Robert Charles2024

    … metabolism catalyzed by reversible isoforms of isocitrate dehydrogenase (IDH1 and IDH2) and undergo rapid cell death when glucose becomes scarce. Reasoning that these cell lines could be used to address basic questions about the contextual roles of IDH1 and IDH2 in regulation of the reductive …

    utswmed Repository record

  2. DPN-linked isocitrate dehydrogenase from fly thoracic muscle mitochondria

    Gu, DeyeVirginia Polytechnic Institute1968

    Both TPN- and DPN-linked isocitrate dehydrogenases have been identified in the thoracic muscle mitochondria from the face fly and the American cockroach. The DPN-linked enzyme from these two insects is closely related on the basis of chromatographic pattern. DPN-linked IDH has been isolated from …

    vt Repository record

  3. Pathological, Immunohistochemical and Molecular Analysis of Recurrent Glioblastoma

    김, 장희2012

    … necrosis. We also examined MIB-1 labeling, isocitrate dehydrogenase 1R132H mutation, and epidermal growth factor receptor amplification in primary and recurrent glioblastomas. To evaluate patient outcomes according to clinical and pathologic parameters, a survival analysis was performed and …

    ajou Repository record

  4. Estudo citoquímico de enzimas mitocondriais de Trypanosoma cruzi em culturas de tecido

    Meirelles, Maria de Nazareth Silveira Leal de MeirellesUniversidade Federal do Rio de Janeiro1978

    … aceptors of the reaction to locace Succinate Dehydrogenase (E.C. 1.3.99.1), Isocitrate Dehydrogenase (E.C. 1.1.42), a Glycerophosphate Dehydrogenase (E.C. 1.1.2.1), b Hydroxybutyrate Dehydrogenase (E.C. 1.1.1.30) and NADPH Tetrazolium Redutase. Light microscopy showed an intense reaction. Blue …

    brazil-uerj Repository record

  5. ANALYSIS OF TUMOR SPECIFIC PROTEIN EXPRESSION IN GLIOBLASTOMA MULTIFORME (GBMs) TUMORS THROUGH IMMUNOHISTOCHEMISTRY

    Wigand, Amanda M2016

    … most fatal form of brain cancer. GBM tumors with isocitrate dehydrogenase-1 (IDH1) mutation being expressed, lead to higher survival rates in patients that also have full resection of the tumor and chemotherapy. Without this mutation, it is thought that tumors have a higher expression of the …

    nmu Repository record

  6. Functional analyses of Plasmodium Falciparum primary metabolic genes

    CHAN KOK LEONG, MAURICE2007

    … and kinetic characterization of P. falciparum isocitrate dehydrogenase, malate dehydrogenase and pyruvate kinase. And, since RT-PCR showed that all the 10 ORFs were actively transcribed during infection, analyses of web-based microarray data were done. These further supported the importance of …

    nus Repository record

  7. Identifying biosynthetic pathways for mycobacterial cell wall components using transposon mutagenesis

    Chen, JieminUniversity of Birmingham2010

    … the M. smegmatis 3D9 Tn-mutant with the only isocitrate dehydrogenase (icd) gene disrupted and the M. marinum 8G10 mutant with a Tn inserted into the promoter region of MMAR0978 with a deficiency in methoxymycolates production. Four mutants resistant to generalised transducing phage I3 were …

    birmingham Repository record

  8. Förster Resonance Energy Transfer-Based Quantification of D-2-Hydroxyglutarate & Locked Nucleic Acid Loop-Mediated Isothermal Amplification Mediated Detection of IDH1-R132 Single Nucleotide Variants in Glioma

    Choate, Kristian A2029

    <p>Isocitrate dehydrogenase 1 (<em>IDH1</em>) is a biomarker in gliomas which provides valuable information on patient prognosis and treatment. Targeted therapies including maximal surgical resection and pharmaceutical mutant IDH inhibitors offer life extending benefits; however, currently …

    nmu Repository record

  9. NEW ADVANCES IN QUANTITATIVE RADIOLOGY: RADIOMICS IN NEURORADIOLOGY APPLIED TO PRIMARY BRAIN TUMORS USING A MACHINE LEARNING APPROACH

    DONISELLI, FABIO MARTINOUniversità degli Studi di Milano2022

    … MGMT promoter (MGMT) methylation status and isocitrate dehydrogenase (IDH) mutation in glioma patients through a multiparametric MRI-based radiomics model, using arterial-spin labelling (ASL) perfusion imaging. Methods: Retrospective single-institution study in a cohort of 52 glioma patients. …

    milano Repository record

  10. Effect of dry period diets varying in energy density on health and performance of periparturient dairy cows: a study of dry matter intake, lactation performance, fertility, blood parameters and liver condition

    Berglind Ósk Óðinsdóttir 1980-2011

    … (Non-esteriffied fatty acids), GLDH (Glutamate dehydrogenase), AST (Aspartat aminotransferase), GGT (Gamma glutamyl transferase), ICDH (Isocitrate dehydrogenase) were analyzed from blood and liver fat was estimated under a microscope. Ketolac® test was used to estimate the level of BHB in milk. …

    ag-u-iceland Repository record

  11. Quantifying the Intracellular Metabolic Network that Establishes the Simultaneous Utilization of Sugars and Aromatic Substrates in Pseudomonas putida KT2440

    Kukurugya, Matthew A.Cornell University2017

    … isotopic flux revealed a decreased flux through isocitrate dehydrogenase and α-ketoglutarate dehydrogenase. In addition, feeding on the substrate mixture induced carbon overflow from the TCA cycle primarily through a significant involvement of malate dehydrogenase activity over the ED pathway in …

    cornell Repository record

  12. Systematic implications of isozyme number variation in Tribe Brassiceae (Brassicaceae).

    Anderson, Jeffrey K.University of Ottawa (Canada)2009

    … and Conringia. Duplications for cytosolic isocitrate dehydrogenase (Idh-2) were observed in members of Brassica, Diplotaxis, Moricandia and Pseuderucaria, confirming that subtribes Moricandiinae and Brassicinae are artificially separated, as indicated by restriction site analysis of …

    ottawa-retro Repository record

  13. Structural and Functional Studies of Escherichia coli Kinases and Phosphatases

    Zheng, Jimin2010

    … both kinase and phosphatase activities, modifies isocitrate dehydrogenase (ICDH) to regulate the flux of isocitrate into the glyoxylate cycle. The structures of Acek alone and in complex with its substrate, ICDH, provided us with information to explain the mechanisms underlying its bifunctionality …

    queens Repository record

  14. Deconvolute Brain Tumor Genomic Alterations Based On Dna Methylation

    Yang, Jie, <p>0000-0003-2241-5066</p>2020

    … is poorly understood. For example, mutation of isocitrate dehydrogenase (<em>IDH</em>) is associated with genome-wide hypermethylation of CpG islands in gliomas. But other subtype-associated alterations, including telomerase reverse transcriptase (<em>TERT</em>)<em> </em>promoter mutation, alpha …

    uthsc Repository record

  15. <i>PTHR1/SOX9</i> and <i>IDH1/IDH2</i> Relative Expression in Primary Chondrocyte and Chondrosarcoma Cells Under the Synergistic Influence of Inducible Hypoxia and Extracellular Acidosis

    Vangjeli, Kostika2020

    … transcription factor 9 (<em>SOX9</em>), and isocitrate dehydrogenase 1 and 2 (<em>IDH1/IDH2</em>). <em>PTHR1</em> and SOX9 keep chondrocytes in a proliferative state and delay their hypertrophy. On the other hand,<em> IDH1</em> and <em>IDH2</em> are metabolic enzymes that convert isocitrate …

    odu Repository record

  16. Studies of a restricted signature of circulating miRNAs as non-invasive biomarker in glioma: from the molecular function to the clinical application

    DIAZ MENDEZ, ANA BELENUniversità degli studi di Catania2022

    … Among the key genetic events, mutations of the isocitrate dehydrogenase (IDH) genes are noteworthy. Altered miRNA profiles have been observed not only in tumour tissues but also in biofluids, where they circulate in a very stable form, making them interesting candidate as biomarkers. Several …

    catania Repository record

  17. A study of the coccoid form and the autolysins of <i>Campylobacter upsaliensis</i>

    Santiwatanakul, SomchaiVirginia Tech1998

    … not prevent the conversion. Severe decreases in isocitrate dehydrogenase activity and oxygen uptake and extensive degradation of ribosomal RNA suggest that the coccoid form is a degenerative form rather than part of a life cycle. The autolysins of spiral and coccoid forms of <i>C. upsaliensis</i> …

    vt Repository record

  18. Magnetic Resonance Spectroscopy Imaging of 2-Hydroxyglutarate in Brain Tumors at 3T and 7T In Vivo

    An, Zhongxu2020

    … resonance spectroscopy (MRS) in patients with isocitrate dehydrogenase mutant gliomas is a significant breakthrough in neuro-oncology imaging. 2HG is the first imaging biomarker that is specific to a genetic mutation in gliomas, making the diagnosis of IDH mutant gliomas possible without …

    utswmed Repository record

  19. MarR Family Transcriptional Regulators from Streptomyces coelicolor

    Huang, HaoBiological Sciences2017

    … (encoding malate synthase), mdh (encoding malate dehydrogenase) and idh (encoding isocitrate dehydrogenase). Moreover, the divergent tam-tamR gene pairs and the predicted TamR binding sites are highly conserved in the promoter regions of its target genes in different Streptomyces species. …

    lsu-thes Repository record

  20. Pyruvate Cycling Pathways and Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells

    Ronnebaum, Sarah Marie2008

    … that NADPH-producing cytosolic enzymes isocitrate dehydrogenase (ICDc) and malic enzyme (MEc) may be involved in both pyruvate cycling and insulin secretion. ICDc expression was reduced using siRNA in the INS-1 derived cell line 832/13 and in isolated rat islets, which led decreased …

    duke Repository record

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