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Showing 1 to 20 of 30 for “"islet transplantation"”.
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Immunoisolation Approaches for Islet Transplantation
The widespread use of islet transplantation as a treatment for type 1 diabetes is limited in part by the necessity for long term immunosuppression. The principle of immunoisolation is to create a physical barrier surrounding the islets to prevent immune destruction after implantation, therefore …
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Strategies for improving islet transplantation outcome
Allogeneic islet transplantation offers the possibility to treat selected patients with brittle Type 1 Diabetes Mellitus (T1DM). Limited availability of islets is a major obstacle to the more widespread use of islet transplantation as a therapy for the majority of patients with T1DM. This is …
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Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation
… in 1990s, the Edmonton Protocol for human islet transplantation has helped more than 500 patients with type 1 diabetes worldwide and met great success from bench to bedside. The Edmonton Protocol involves isolating islets from a cadaveric donor pancreas by enzymatic digestion and infusing …
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RNA Interference for Improving the Outcome of Islet Transplantation and Polymeric Micelle‑based Nanomedicine for Cancer Therapy
… transfer has been used to improve the outcome of islet transplantation for treating type I diabetes. RNA interference is an effective approach for reducing gene expressions at the mRNA level. The application of RNA interference to improve the outcome of islet transplantation was reviewed in …
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Targeting toll-like receptor 4 related inflammation using small molecule, TAK-242, to attenuate inflammatory damage in pancreatitis and islet transplantation.
… results in detrimental outcomes in pancreatic islet transplantation which can be utilized to replace beta cell mass lost during type 1 or type 3c diabetes. Toll-like receptor 4, a pattern recognition receptor found on various immune, endothelial, and epithelial cells, can respond to both …
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Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
… Thrombomodulin (TM) and CD47, on the surface of islets to promote islet engraftment by controlling thrombotic/inflammatory reactions associated with an immediate blood-mediated inflammatory response (IBMIR). In chapter 3, syngeneic pancreatic islets are engineered with a novel form of TM (SA-TM) …
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Evaluation of a high-yield technique for pancreatic islet isolation from deceased canine donors
… and frequent complications. Pancreatic islet transplantation is a noninvasive and potentially curative treatment for T1DM. We hypothesized that clinically acceptable islet yield and purity could be achieved by using deceased canine donors and standard centrifugation equipment. Pancreata …
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Eliminating oxygen supply limitations for transplanted microencapsulated islets in the treatment of type 1 diabetes
… Insulin is produced by [beta]-cells in the Islets of Langerhans, which are aggregates of cells averaging about 150 [mu]m in diameter and constituting about 1 to 2% of the pancreas volume. The efficacy of islet transplantation as a treatment for diabetes has been demonstrated in humans by the …
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Inhibition of TLR4 minimizes islet damage due to sterile inflammation and improves islet transplant outcomes.
Islet transplantation has emerged as an important treatment option for brittle type 1 diabetes and as an adjunct procedure after total pancreatectomy to prevent brittle diabetes. The efficacy and long-term function of islet transplantation have significantly improved over the last two decades. …
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Biopolymers for Bioartificial Pancreas
… in the last decade, after the first successful islet transplantation in 2000. Islets are clusters of endocrine cells found in the pancreas. Amongst these cells, the insulin secreting beta cells are targeted by the immune system in Type 1 Diabetes. One of the major challenges islet …
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Dynamic contrast-Enhanced MRI of Pancreatic Islet Transplants
… by the loss of insulin-producing pancreatic islets, transplantation of donor islets has the potential to not only supplement insulin replacement therapy but to cure type 1 diabetes. However, long-term insulin independence (> 2 years post-transplant) remains a challenge partly due to low islet …
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Maintaining islet quality during culture
Islet transplantation has become a promising treatment for type I diabetes mellitus due to recent success since the development of the Edmonton Protocol. Islet culture prior to transplantation is standard practice in most clinical islet programs. Conventional culture conducted on polystyrene …
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Fabrication of reinforced alginate fibers for cell based therapies
… after each meal in order to remain euglycemic. Transplantations of islet cells in immuno-protective alginate capsules has been shown to be promising as a long-term cure for Type I Diabetes. In this study, reinforced alginate fibers were fabricated as an alternative to alginate capsules for islet …
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Characterization of pattern recognition receptor responses against materials for cell encapsulation
Islet transplantation has significant potential for the treatment of type I diabetes, but an immunoprotective barrier is necessary to protect the donor tissue from host rejection and to eliminate the need for systemic immunosuppressive therapy. Cell encapsulation is an attractive technology to …
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Therapeutic Gene Delivery to Human Pancreatic Islets for Treatment of Diabetes and the Effect of TFO on Liver Fibrosis Induced by Bile Duct Ligation
… gene transfer can improve the outcome of islet transplantation for treating Type I diabetes. Earlier we have shown co‑expression of human vascular endothelial growth factor (hVEGF) and human interleukin‑1 receptor antagonist (hI‑1Ra) after transfection of plasmid DNA encoding these two …
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Overcoming Diffusion Limitations in Encapsulated Cell Therapy for Type 1 Diabetes
… delivery systems, the pancreatic islet is still functionally superior at regulating blood glucose levels. Pancreatic islet transplantation requires immune suppression, but islet encapsulation would eliminate this requirement. A hydrogel encapsulation barrier, made from alginate, …
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Development of orthogonally crosslinked thiol-ene hydrogels for encapsulation of pancreatic beta-cells
… strategies can protect the transplanted islets from direct attack by host immune cells while maintaining insulin secretion. To achieve this goal, I have developed a hydrogel conformal coating using a visible light-mediated interfacial thiol-ene photopolymerization. Unlike conventional …
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Targeted Epigenetic Editing to Increase Adult Pancreatic Β-Cell Proliferation
… as demonstrated by the success of pancreatic islet transplantation in type 1 diabetes. However, there are an insufficient number of organ donors to meet the demand of this disease, which is increasing in prevalence. One strategy to increase the supply of human β-cells for transplantation in …
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Stem cell-based regenerative pharmacology for the treatment of diabetes mellitus
… leads to serious long term complications. Transplantation of whole pancreas or isolated islets are promising approaches to restore insulin production in these patients; however, the severe shortage of organ donors and risk of allogeneic graft rejection have limited this treatment. Stem …
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Novel Roles of Gastrin and Cholecystokinin in Islet Beta Cell Proliferation
… of several factors. In the last decade, islet transplantation has re-emerged as a viable option for the treatment of Type 1 diabetes, thanks to greatly improved islet isolation protocols and immunosuppressive regimens. Despite these advancements, the supply of available islet beta cells …
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