Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"islet amyloid polypeptide (IAPP)"”.
-
Small Molecules as Amyloid Inhibitors: Molecular Dynamic Simulations with Human Islet Amyloid Polypeptide (IAPP)
Islet amyloid polypeptide (IAPP) is a 37-residue amyloidogenic hormone implicated in the progression of Type II Diabetes (T2D). T2D affects an estimated 422 million people yearly and is a co-morbidity with numerous diseases. IAPP forms toxic oligomers and amyloid fibrils that reduce pancreatic …
-
Insights into Mechanisms of Amyloid Toxicity: Molecular Dynamics Simulations of the Amyloid andbeta-peptide (Aandbeta) and Islet Amyloid Polypeptide (IAPP)
Aggregation of proteins into amyloid deposits is a common feature among dozens of diseases. Two such diseases that feature amyloid deposits are Alzheimer's disease (AD) and type 2 diabetes (T2D). AD toxicity has been associated with the aggregation and accumulation of the amyloid β-peptide (Aβ); Aβ …
-
Insulin based inhibitors of human islet amyloid polypeptide (hIAPP) and their effect on hIAPP- mediated membrane damage in type 2 diabetes mellitus
<p>Amylin (Islet Amyloid Polypeptide, IAPP) is a 37 amino acid polypeptide, co-secreted with insulin from pancreatic beta cells, that plays a role in the damage of cell membranes by forming amyloid fibrils in Type 2 diabetes. Insulin has been found to inhibit hIAPP (Human Islet Amyloid Polypeptide) …
-
Rational Design and Application of Antibodies for Amylin and Amyloid Beta
Misfolded proteins and polypeptides such as amylin (islet amyloid polypeptide, IAPP) and amyloid beta are associated with numerous age-related pathological conditions such as Alzheimer's, Parkinson's, and type II diabetes, but effective treatments for these diseases are currently lacking. …
-
Characterisation of neurodegenerative diseases derived protein aggregates using improved single-molecule pull-down
… to characterise soluble α-Synuclein (αS) and Amyloid-β (Aβ) aggregates in serum from patients with PD and controls. Our findings reveal that the ratio of detected aggregates (αS/(Aβ+αS)) and morphological information of αS aggregates can be differentiated between PD samples and controls. We …
-
Investigating the Electrostatic Properties and Dynamics of Amyloidogenic Proteins with Polarizable Molecular Dynamics Simulations
Amyloidogenic diseases, such as Alzheimer's disease (AD) and Type II Diabetes (T2D), are characterized by the accumulation of amyloid aggregates. Despite having very different amino-acid sequences, the underlying amyloidogenic proteins form similar supramolecular fibril structures that are highly …
-
The Molecular Interaction Between Type Ii Diabetes and Alzheimer’S Disease Through Cross-Seeding of Protein Misfolding
… and progressive dementia characterized by amyloid-beta (Aβ) plaques, neurofibrillary tangles (NFTs), neuronal loss, brain inflammation, and cognitive impairment. T2D involves the dysfunctional use of pancreatic insulin by the body resulting in insulin resistance, hyperglycemia, …
-
Amylin, tissue hypoxia and metabolic dysregulation in diabetic heart and liver
… to different levels of metabolites. Amylin, or islet amyloid polypeptide (IAPP), is a 37 amino-acid peptide hormone, that is co-secreted with insulin from pancreatic β-cells in response to nutrient stimuli. Amylin dyshomeostasis occurs in T2DM. Initially, as peripheral insulin resistance …