Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 543 for “"ischemic"”.
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Role of Cofilin, an Actin Cytoskeletal Protein, in Ischemic Conditions: Potential Therapeutic Target for Ischemic Stroke
… of disease states like Alzheimer’s and ischemic kidney disease. We have hypothesized possible involvement of cofilin in cerebral ischemia and neurodegeneration. To investigate the potential actin cytoskeletal changes induced by cofilin in ischemia, various ischemic models such as …
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Vascular receptor changes in ischemic stroke
The present thesis aimed to examine how ischemic stroke affects the vascular endothelin and angiotensin systems in cerebral arteries. To study vascular receptor changes in ischemic stroke transient focal ischemia was induced in rats. In addition, rat cerebral arteries and arterial smooth muscle …
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Modeling oxygen requirements in ischemic cardiomyocytes
Ischemic heart disease remains a leading cause of death globally and in the US. The most common ischemic event is a heart attack, where one or more arteries are obstructed and the cardiac muscle is deprived of oxygen. Although removing the blockage and allowing reperfusion can prevent death, at the …
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Aging Exacerbates Neutrophil Pathogenicity In Ischemic Stroke
<p>Ischemic stroke is a major cause of disability and mortality worldwide. As most patients cannot receive the currently approved therapies for ischemic stroke, novel treatments are critically needed. Cerebral ischemia causes irreversible tissue damage, referred to as the “tissue core”, which is …
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Effects of Ischemic Preconditioning on Exercise Economy
<p>Ischemic preconditioning (IPC) is the application of small bouts of ischemia followed by reperfusion. IPC has shown to enhance exercise performance in varied sports like 5K running, cycling and swimming. However, effect of ischemic preconditioning on running economy have not be investigated so …
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Radiation induced vascular disease and ischemic stroke.
Contains fulltext : 74396.pdf (Publisher’s version ) (Open Access)
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Pre-clinical Targets for Ischemic Brain Injury
… axons located in white matter is observed in ischemic injuries but is generally underappreciated. Research has shown that there is extensive vesicular glutamate release during ischemia, causing excitotoxic injury to oligodendrocytes, resulting in demyelination. Glutamate receptor antagonists …
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fMRI assessment of ischemic stroke in humans
… find certain levels of difference between the ischemic lesions and normal tissues.
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The Role of Wnt3a in Ischemic Stroke
<p>After ischemic stroke, apoptosis of neurons is a primary factor in determining outcome. Wnt3a is a naturally occurring protein that has been shown to have protective effects in the brain for traumatic brain injury. Although wnt3a has been investigated in the phenomena of neurogenesis, …
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Clinical Prediction of Perinatal Arterial Ischemic Stroke
… deficits lasting a lifetime. Perinatal arterial ischemic stroke (PAIS) is the most common type of perinatal stroke. Advances in neuroimaging have allowed for exceptional growth in stroke diagnosis. However, etiology is poorly understood. Many pregnancy, delivery, and fetal risk factors have been …
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Therapeutic Targeting of Arteriogenesis Following Ischemic Stroke
… in the United States, predominantly caused by ischemic events. Ischemic strokes occur when a clot or other obstruction lodges in a blood vessel of the brain, restricting the movement of blood. Subsequent rapid cell death occurs and often leads to long term neurological deficits. Pial …
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Early Identification of Dysphagia Post Pediatric Ischemic Stroke
Pediatric stroke has received increasing attention over the last few decades. Dysphagia is commonly reported following acute stroke in adults, leading to negative health complications such as pneumonia and mortality; however, dysphagia is not a well understood outcome post-stroke in pediatrics. …
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ROLE OF CIRCULAR PVT1 IN ISCHEMIC HEART FAILURE
… interactions and their respective functions in ischemic HF (IHF) remain largely unknown. This study aimed to identify circRNA-based ceRNA networks in non-end-stage IHF. Transcriptome analysis of left ventricles of IHF patients identified significant differentially expressed circRNAs, miRNAs and …
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Mean Arterial Pressure in Acute Ischemic Stroke Study
… blood pressure (NIBP) devices to guide acute ischemic stroke (AIS) patients’ treatment. Although systolic blood pressure (SBP) has been found to be the most unreliable measurement displayed on NIBP devices, treatment decisions for AIS are based on them. Today, 25 years after the FDA’s approval …
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Spatial analysis of ischemic heart disease in Manitoba
… of interest for this research project was ischemic heart disease (IHD). Objectives: The purpose of this project was to use statistical tools to detect spatial and temporal patterns of IHD in Manitoba. The objectives were to: (1) detect geographic clusters of acute myocardial infarctions …
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Neuropsychological Effects of Pomegranate Supplementation Following Ischemic Stroke
… recovery in individuals who had suffered an ischemic stroke. We administered polyphenols via 2 POMx pills containing polyphenols derived from pomegranates equivalent to the content of approximately 8 ounces of pomegranate juice, or placebo pills (capsules containing no polyphenol …
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Angiogenesis and Myogenesis in a Chronic Ischemic Heart.
<p>Miniswine underwent procedures to evaluate treating chronic ischemia with the implantation of autologous satellite cells and laser transmyocardial revascularization (TMR). The objective was to combine two therapies to restore cardiac function. This experiment involved three surgical procedures: …
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INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME
<p>Cerebrovascular disease (stroke), especially ischemic stroke, is a major cause of death and neurological disability in adults. Because of its clinical heterogeneity, stroke is considered as a multi-factorial and polygenic disorder. Most current genetic studies of ischemic stroke focus on genetic …
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Brain regeneration in a hypoxic-ischemic mouse model
… of new cells in the damaged tissue. Hypoxic ischemic lesion was observed in striatum, hippocampus and cortex region, and damaged tissue was getting worse up to day 4 after HI (p11). Numerous apoptotic and necrotic neuron has been observed in early phage after the injury, but two weeks later …
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