Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"ischemia-reperfusion"”.
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INTRA-MITOCHONDRIAL INJURY DURING ISCHEMIA-REPERFUSION
Cardiac injury is increased following ischemia-reperfusion. Mitochondria are the “effector organelles” that are damaged during ischemia (ISC) when there is no blood flow. Resumption of metabolism by damaged mitochondria during reperfusion (REP) results in increased cell injury. Current therapeutic …
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Treatment of Ischemia Reperfusion Injury with RNA Interference
Ischemia reperfusion injury (IRI) occurs during transplantation and causes apoptosis and inflammation. The purpose of this research was to determine the effect of caspase-3, complement 3, and RelB gene silencing in the reduction of IRI using an in vitro model. LLC-PK1 cells were used along with …
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Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury
… (MI), where it plays an important role in ischemia-reperfusion (I/R) injury. Considerable progress has been made towards identifying physiological and pharmacological agents that play a key role in myocardial preconditioning against I/R injury and also elucidating the molecular changes …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… exhibited anti-apoptotic properties on cerebral ischemia injury. HNG reduced infarct volume after ischemia/reperfusion injury with pre-treatment or post-treatment (i.c.v. and i.p.) in a middle cerebral artery occlusion model in mice and decreased neurological deficits induced by ischemia. The …
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Flavonoid protection of cardiac cells against ischemia-reperfusion injury
Myocardial ischemia-reperfusion injury occurs following the majority of cardiac events including myocardial stenosis and heart surgeries. As reactive oxygen species are one of the major contributors to ischemia-reperfusion injury, strategies to prevent their effects may be directed towards …
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Early Mediators of Cutaneous Ischemia Reperfusion Injury: A Mouse Model
… been proposed to be the repetitive incidence of ischemia reperfusion injury.A mouse model of cyclic ischemia reperfusion was employed to examine the initiation events in the pathology of chronic wounds. Mice were subjected to eight hours of magnetic skin compression via four cycles of two-hours …
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Cardiovascular Risk, Remote Ischemic Postconditioning, and Endothelial Ischemia-Reperfusion Injury
… stimulus that is thought to reduce reperfusion injury associated with heart disease. However, certain animal models of cardiometabolic risk factors such as dyslipidemia, diabetes, and hypertension suggest the beneficial effects of rIpost to lessen reperfusion injury may be …
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Mitochondrial Dynamics: Exploring A Novel Target Against Myocardial Ischemia-Reperfusion Injury
… as a mediator of cell fate in the setting of ischemia-reperfusion (IR) injury, and, ii) inhibition of DRP1 and mitochondrial fission provides cardioprotection against IR injury. However, the precise role of DRP1 translocation to mitochondria in the pathogenesis of myocardial …
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Proteomic Discovery of Functionally Important Pathways in Myocardial Ischemia-Reperfusion Injury
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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α-Lipoic Acid Attenuates Ischemia Reperfusion Injury of the Rat Liver
107 Ischemia reperfusion injury (IRI) represents a major clinical problem in liver transplantation and resection. Main pathophysiological events during this injury comprise depletion of ATP, Kupffer cell activation with subsequent formation of reactive oxygen species and inflammatory response. …
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Apoptosis in the equine small intestine following experimental ischemia-reperfusion injury
… equine small intestine subjected to experimental ischemia-reperfusion injury and determining if use of an angiotensin converting enzyme inhibitor (enalaprilat) would ameliorate the apoptotic response. It was designed to determine if mucosal epithelial cells undergo apoptosis during the ischemia …
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PATHOGENIC ROLE OF PHOSPHODIESTERASE TYPE 5 UPREGULATION IN CARDIAC ISCHEMIA/REPERFUSION INJURY
… 5 (PDE5) inhibitors are cardioprotective against ischemia/reperfusion (I/R) injury. However, it remains uncertain if I/R affects PDE5. We hypothesized that generation of reactive oxygen species (ROS) during I/R leads to upregulation of PDE5, which contributes to pathological changes following …
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Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model.
… the clinical setting. Perioperative myocardial ischemia occurs more often than recognized. This may lead to myocardial infarction, increased morbidity, mortality, and health care costs. In the first study, myocardial metabolism was investigated before, during, and after 30 min of regional …
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Influence of Antithymoglobulins on Ischemia/Reperfusion Injury in perfused non-human primate tissues
Hintergrund: Der Ischämie-Reperfusionsschaden ist ein unspezifischer, Antigen unabhängiger pathophysiologischer Prozess, welcher bedeutenden Einfluß auf das Überleben transplantierter Organe hat. Antithymozyten-Globuline (ATGs) werden als Immunsuppressiva in der Therapie akuter Abstoßungsepisoden …
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Prevention of Ischemia-Reperfusion Injury in the Rat Liver by Atrial Natriuretic Peptide
… the protective effects of ANP preconditioning in ischemia-reperfusion injury of the isolated perfused rat liver. It was of particular interest to evaluate the influence of ANP on the mode of cell death occurring during cold ischemia and reperfusion and to elucidate the involved signal transduction …
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