Global ETD Search
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Showing 1 to 15 of 15 for “"ischaemic-preconditioning"”.
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ENHANCING EXERCISE PERFORMANCE THROUGH ISCHAEMIC PRECONDITIONING
Ischaemic preconditioning (IPC) is an intervention whereby brief intermittent ischaemic episodes are induced in a limb (usually 4x5-minute arterial occlusion bouts, interspersed with 5-minutes of reperfusion) either at the site of interest (IPC), or at a distance from the site of interest (Remote; …
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Ischaemic preconditioning in exercise and disease: One size fits all?
… protective effects. This mechanism is called ischaemic preconditioning (IPC). In this thesis, the impact of co-morbidity and age on IR-injury and IPC are explored. Moreover, the possible role of IPC to enhance exercise performance is investigated. Finally an attempt is made to understand the …
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The impact of ischaemic preconditioning on cerebrovascular function in healthy individuals.
Introduction: Remote ischaemic preconditioning (RIPC) refers to non-lethal repeated bouts of ischaemia followed by reperfusion applied to a vascular bed, tissue or organ rendering protection to future ischaemic events. RIPC has been reported to enhance functional recovery from heart attacks and …
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Application of remote ischaemic preconditioning to human coronary artery bypass surgery
… of intermittent upper limb ischaemia (remote ischaemic preconditioning (RIPC)) were compared in non-diabetic adult patients undergoing on-pump multi-vessel coronary artery surgery. Patients, investigators, anaesthetists, surgeons and critical care teams were all blind to group allocation. …
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Remote, non-invasive ischaemic preconditioning of skeletal muscle flaps against ischaemic necrosis : efficacy and mechanism
HYPOTHESIS: That skeletal muscle, throughout the body, can be preconditioned to better withstand prolonged periods of ischaemia, by first subjecting a remote muscle to brief, non-invasive and sub-lethal, cycles of ischaemia and reperfusion, using a hindlimb tourniquet.
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Investigating the role of toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury
Ischaemic heart disease remains a significant cause of death throughout the developed world. Although technological advancements and improved health care have significantly reduced mortality rates in the last century, additional research is required. Recently myocardial inflammation has drawn …
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Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart
Cardiac ischaemic preconditioning (IPC) describes a biological phenomenon whereby a short ischaemic stimulus confers protection to the heart against subsequent prolonged ischaemia and reperfusion injury. Understanding this survival programme will enable us to augment tissue tolerance against cell …
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Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease
… include limiting reperfusion injury by remote ischaemic conditioning (RIPC), a powerful protective mechanism that can be elicited by the transient occlusion of blood flow to a limb with a blood pressure cuff. More controversially, glucose-insulin-potassium (GIK) therapy in early ST elevation …
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Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries
… density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but the mechanisms involved remain unclear. Janus kinase/Signal transducer and activator of transcription 3 (JAK/STAT-3) form part of a …
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Investigation of different blood pressure regulating systems in kininogen-deficient BNK rats
… 30min global ischaemia with or without previous ischaemic preconditioning (IPC) were investigated. Myocardial damage was judged by the creatine kinase activity in the coronary effluent measured with a specific kit. BNK rats are characterized by plasma kininogen deficiency that is reflected in …
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The protective role of tumour necrosis factor alpha in the heart
… is produced by the heart in response to the ischaemic preconditioning (PC) stimulus. We hypothesised that this endogenously produced peptide may play a role in activating the ischaemic PC mediated tolerance towards a subsequent ischaemic insult in muscle cells. To test this and to delineate …
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Reactive oxygen species and mitochondrial metabolism in acute myocardial ischaemia reperfusion injury: measurement and modulation
… is a major driver of damage upon reperfusion of ischaemic tissue. ROS are however increasingly understood to not only have negative effects, but also to act as biological signalling molecules that are able to activate protective pathways. In order to investigate how such antagonistic processes …
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Novel Interventions to Improve Cerebral and Peripheral Vascular Function
… in individuals at high risk of CVD. Remote ischaemic preconditioning (rIPC), which involves cyclical periods of ischaemia-reperfusion applied noninvasively to a limb, has been shown to improve measures of peripheral vascular function and cardiovascular endpoints when applied acutely (one …
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Studies on preconditioning with adenosine, glutamate and ouabain in rat hippocampal slices
Preconditioning is the phenomenon whereby tolerance to lethal insults is induced by exposing the tissue to a prior sublethal stimulus. This exists in several forms, such as ischaemic preconditioning, adenosine preconditioning and excitotoxic preconditioning. Adenosine preconditioning is known to be …