Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"ischaemia reperfusion injury"”.
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Mitochondrial Metabolism in Ischaemia Reperfusion Injury
Ischaemia reperfusion (IR) injury is caused by the re-introduction of oxygenated blood flow to tissues after a period of ischaemia. It is an inevitable consequence of organ transplantation, where its severity contributes to reduced levels of graft function and survival. There are no clinically …
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Mitochondrial dysfunction during ischaemia reperfusion injury in models of organ transplantation
… occurring during this surgical procedure, ischaemia reperfusion injury (IRI), is still a major contributor causing poor outcome. Ischaemia arises due to the lack of blood supply, leaving the tissue without oxygen and substrates, which are crucial for energy generation. Upon reperfusion with …
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Investigating complex I dynamics and ROS production in ischaemia-reperfusion injury
Ischaemia-reperfusion (IR) injury is caused paradoxically when the flow of oxygenated blood to an organ is restored after a period of restricted blood supply (ischaemia) in the course of a heart attack, stroke or organ transplantation. Mitochondria play a central role in the pathology of IR injury …
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The role of ischaemia-reperfusion injury and mitochondrial dysfunction in organ transplantation
Summary The role of ischaemia-reperfusion injury and mitochondrial dysfunction in organ transplantation Ischaemia and subsequent reperfusion is inherent to solid organ transplantation and contributes to tissue damage, organ dysfunction, and worse recipient outcome. Demand for organs for …
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The role of platelets and their associated recruitment mechanisms, in intestinal ischaemia reperfusion injury
… in the pathophysiology of intestinal ischaemia-reperfusion (IR) injury. The research described in this thesis investigates the role of the major platelet glycoprotein receptors in recruiting and activating platelets following intestinal IR injury, namely GPVI, GPIb-IX-V and the …
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Reactive oxygen species and mitochondrial metabolism in acute myocardial ischaemia reperfusion injury: measurement and modulation
… intermediate succinate that accumulates during ischaemia. This is a major driver of damage upon reperfusion of ischaemic tissue. ROS are however increasingly understood to not only have negative effects, but also to act as biological signalling molecules that are able to activate protective …
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Complement activation and effector pathways in ischaemia reperfusion injury and at the interface with adaptive immunity
Ischaemia reperfusion injury (IRI) is an important source of morbidity and mortality and contributes to renal transplant failure. Renal IRI is known to be mediated by complement, which causes direct injury to the transplant and stimulates the adaptive immune response against transplant antigens. …
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Evaluation of a novel mitochondria‐targeted anti-oxidant therapy for ischaemia-reperfusion injury in renal transplantation
Ischaemia-reperfusion (IR) injury makes a major contribution to graft damage during kidney transplantation and increases the risks of primary non-function, delayed graft function and rejection. Oxidative damage to mitochondria is a key early event in IR injury. The aim of this project was to …
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Developing an adjunct therapy to mechanical thrombectomy in a murine model of stroke ischaemia reperfusion injury
… stroke as it allows for more rapid and complete reperfusion of the ischaemic tissue compared to recombinant tissue plasminogen activator (rtPA) alone. The advancements in imaging techniques, together with MT, have extended the therapeutic window of reperfusion therapy and have enhanced patient …
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Influence of upper limb ischaemia-reperfusion injury on the regulation of cutaneous blood flow during local thermal hyperaemia
… to investigate the effects of acute upper limb ischaemia- reperfusion (I-R) on neurovascular and endothelial control of the cutaneous micro-circulation in the forearm and finger by evaluating its influence on the magnitude and kinetics of the vasodilatory response to local skin heating. Study 1 …
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Mitochondrial Metabolism Elucidated by Rapid Fractionation from Tissue
… and mitochondrial dysfunction, such as ischaemia-reperfusion injury. A detailed understanding of the metabolic changes in different cellular pools would aid diagnosis and treatment. However, the current methods of mitochondrial isolation are too slow to provide a snapshot of purely …
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Developing methods for measuring mitochondrial redox status and membrane potential in the isolated perfused heart
… have been identified as a key player in cardiac ischaemia-reperfusion injury serving as both a source and target of damage. The energetic status of mitochondria critically determines the progression of ischaemia-reperfusion injury by dictating the thermodynamic likelihood of reverse electron …
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Cardioprotective effects of Glucagon-like Peptide 1 (GLP-1) and their mechanisms
… been demonstrated to protect against non-lethal ischaemia reperfusion injury in the left ventricle in humans. It has been suggested from some animal research that this protection may be mediated through the pathway of ischaemic conditioning, of which the opening of the mKATP channel is a key …
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MicroRNAs as biomarkers of injury and drug response in renal transplantation
… have both endured and are more susceptible to ischaemia reperfusion injury (IRI), are being utilised for transplantation. As such, predicting and mitigating the impact of ischaemia reperfusion injury (IRI) remains a key priority in renal transplantation (RT). The small non-coding RNAs, …
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Ischaemic preconditioning in exercise and disease: One size fits all?
Ischaemia reperfusion injury (IR-injury) occurs when blood supply to a certain area of the body is blocked, and is subsequently followed by reperfusion. During the period of ischaemia, tissue is damaged as a result of lack of oxygen. Rapid reperfusion is mandatory, but unfortunately causes damage …
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Examining the regional physiology of the transplant kidney during normothermic machine perfusion.
Ischaemia-reperfusion injury (IRI) is an unavoidable consequence of deceased-donor kidney transplantation that has a profound effect upon both immediate and long-term graft function. Disruption to microvascular perfusion (MVP) and tissue oxygenation (PtO2) are central to the development of IRI, but …
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Omics analysis in understanding disease mechanisms
… time-series untargeted metabolomics in studying ischaemia reperfusion injury was investigated. Employing various models, the study characterized mechanistic metabolic pathways and enzymes that exhibit differential expression across human, pig, and mouse hearts and across ischaemia-prone tissues. …
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