Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"iron transporter"”.
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Heterologous overexpression, purification, and characteristion of the Plasmodium falciparum vacuolar iron transporter, PfVIT
… The efforts made so far identified the iron homeostasis and the transport mechanisms involved in its regulation process, as a weak point of the intraerythrocytic Plasmodium parasite. In fact, many antimalarials already target the parasite’s iron detoxification pathways. However, there is …
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THE DIVALENT CATION TRANSPORTER NRAMP IN PARASITE PERKINSUS MARINUS: GENOMIC, MOLECULAR, STRUCTURAL, FUNCTIONAL AND EVOLUTIONARY ASPECTS
… great hurdle for oyster population restoration. Iron was shown to be an essential element for P. marinus growth and virulence, but iron uptake pathways have not been elucidated. Natural Resistance-associated Macrophage Protein (Nramp), an iron transporter, was considered to be a potential …
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Preparation and evaluation of tumour-targeted delivery systems for tocotrienol
… delivery system. Transferrin is an iron transporter whose receptors are often over-expressed in cancer cells due to high iron demand for tumour growth. Conjugation of transferrin to drug delivery systems appeared to be an attractive tool for selective receptor-mediated tumour …
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Small molecules that imperfectly replicate protein function of missing proteins restore physiology in yeast and human epithelia
… diseases that are caused by missing protein ion transporters, including cystic fibrosis and microcytic anemia. Like many other human diseases caused by missing proteins, these diseases are difficult to treat, and new approaches are needed. Some small molecules can perform ion transporter-like …
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Roles for multiple iron acquisition systems in Vibrio cholerae
… is a highly successful human pathogen and environmental organism. To thrive in these diverse environments, it must encode the tools necessary to acquire essential nutrients such as iron. A number of V. cholerae iron acquisition systems have been identified, and altogether are necessary for …
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From yeast to animals: A small molecule restores iron mobilization, absorption and hemoglobinization
… this strategy is no longer viable. Disorders of iron metabolism are the most prevalent genetic diseases worldwide and currently, there are more than 25 different human hereditary diseases associated with loss of iron transporter function and therefore aberrant iron transport, homeostasis and/or …
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Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies
… by mutations in critical ion channels and transporters, such as microcytic anemias, cystic fibrosis, and cardiovascular diseases. Deficiencies of these ion transporting proteins diminish ion flux in distinct sites and directions. Noting the many features that make small molecules …
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Mechanisms of Iron Acquisition Employed by Neisseria Gonorrhoeae for Survival within Cervical Epithelial Cells
… has evolved a repertoire of high-affinity iron acquisition systems to facilitate essential iron uptake in the human host. Acquisition of iron requires both the energy-harnessing cytoplasmic membrane protein, TonB, as well as specific outer membrane TonB-dependent transporters (TdTs). The …
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Effects of carbohydrates on iron metabolism in intestinal and liver cells
Iron deficiency and excess are worldwide public health problems. Studies suggest that carbohydrates such as fructose, and oligo-and polysaccharides (prebiotics), increase iron bioavailability, but results are inconclusive. There is also interest in whether iron and fructose contribute to the …