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Showing 1 to 20 of 20 for “"iron transport"”.
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Investigating Iron Transport and Utilization Features of Acinetobacter baumannii
… infections. The bacterium must overcome iron starvation and oxidative stress conditions imposed by the host in order to propagate and cause disease. This work further investigates the transport and utilization of iron by <i>A. baumannii</i>, and their involvement in virulence. The …
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Studies on the role of hephaestin and transferrin in iron transport
Iron homeostasis is essential for maintaining the physiological requirement for iron while preventing iron overload. Multicopper ferroxidases regulate the oxidation of Fe(II) to Fe(III), circumventing the generation of harmful hydroxyl-free radicals. Ceruloplasmin is the major multicopper …
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Restored iron transport by a small molecule promotes absorption and hemoglobinization: discovery, development, and mechanistic studies
… by mutations in critical ion channels and transporters, such as microcytic anemias, cystic fibrosis, and cardiovascular diseases. Deficiencies of these ion transporting proteins diminish ion flux in distinct sites and directions. Noting the many features that make small molecules …
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Comparison of expression pattern and localization of iron transport proteins in rat liver, brain and spleen during acute phase response:invivo and invitro studies
… und unterschiedliche Lokalisation der Eisentransportproteine zu vergleichen, Transferrin-Rezeptor (TfR) -1 und 2, divalenten Metallions transpoter-1 (DMT-1) und Ferroportin-1 (FPN-1) in Ratten Leber, Gehirn und Milz während der Akutphase-Antwort auf experimentelle Gewebeschädigung. …
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From yeast to animals: A small molecule restores iron mobilization, absorption and hemoglobinization
… this strategy is no longer viable. Disorders of iron metabolism are the most prevalent genetic diseases worldwide and currently, there are more than 25 different human hereditary diseases associated with loss of iron transporter function and therefore aberrant iron transport, homeostasis and/or …
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The Impact of Iron on Lysosomal Function in the Retinal Pigment Epithelium
Iron has an essential role in numerous biological processes, where its multiple oxidation states enable it to facilitate electron transfer reactions. However, this property also makes iron overload dangerous, as iron can catalyze the formation of reaction oxygen species. Iron overload has been …
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A role for iron in oesophageal adenocarcinoma
… and experimental evidence associates iron with OAC. Our understanding of iron physiology has increased enormously in recent years due to the elucidation of transport proteins and regulatory pathways. Haem scavenging and metabolism remains to be clearly characterised although candidate …
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Thermodynamic Investigations of Metalloproteins: Metal as Probe and Protein as Probe
… dissertation several metalloproteins, both metal transport proteins and the classic metalloprotein hemoglobin, are investigated using a variety of biophysical and electrochemical techniques. In each case, thermodynamic measurements provide insight into the role and mode of action of the …
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Signal Transduction and Transcriptional Regulation Pathways Essential for Azole Resistance in Candida albicans
… genes involved in sterol biosynthesis as well as iron transport and homeostasis in the absence of UPC2. Taken together, our results demonstrate that the UPC2 transcriptional network is universally essential for azole resistance in C. albicans and represents an attractive target for enhancing azole …
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Lipocalin 2 Promotes The Establishment of A Pro-Tumorigenic Microenvironment In Pancreatic Cancer
… manner. Finally, because LCN2 is involved in iron transport, we showed that LCN2’s effects on hPSCs were also mediated by changes in iron levels. Overall, our results suggest a model for LCN2 function in the regulation of the tumor microenvironment and shown its ability to promote tumor growth …
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The effects of exercise on iron metabolism in adult female rats
The effects of exercise training and iron intake on iron metabolism in adult female rats were investigated. Adult female Sprague-Dawley rats were assigned to either an exercise (E) or sedentary (S) group and fed either a diet containing 9 ppm (9) of dietary iron (low iron level), or 40 ppm (40) of …
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An investigation into the structure and functional aspects of the cell wall of Desulfovibrio
… walls from Desulfovibrio vulgaris cells grown in iron rich (C+Fe) and iron poor (C-Fe) media were obtained by partial detergent solubilisation of the cell envelopes. Polyacrylamide gel electrophoresis (PAGE) has shown the presence in the outer membrane (OM) of three major proteins (OMPs l, 2 and …
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Roles for multiple iron acquisition systems in Vibrio cholerae
… is a highly successful human pathogen and environmental organism. To thrive in these diverse environments, it must encode the tools necessary to acquire essential nutrients such as iron. A number of V. cholerae iron acquisition systems have been identified, and altogether are necessary for …
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Electrochemical and genetic tools for analysing and engineering bioenergetic processes in cyanobacteria
… It is catalysed by photosynthetic electron transport chains: a collection of free and proteinbound redox cofactors found within the specialised thylakoid membranes of photosynthetic organisms. Cyanobacteria, to our knowledge, are the first organisms to have evolved oxygenic photosynthesis, …
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Heterologous overexpression, purification, and characteristion of the Plasmodium falciparum vacuolar iron transporter, PfVIT
… The efforts made so far identified the iron homeostasis and the transport mechanisms involved in its regulation process, as a weak point of the intraerythrocytic Plasmodium parasite. In fact, many antimalarials already target the parasite’s iron detoxification pathways. However, there is …
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Molecular Mechanism of Ferricsiderophore Transport via the Outer Membrane Receptor FhuA in <em>Escherichia coli</em>.
<p>Iron is essential for life and growth in most organisms. Although it is abundant, iron exists mostly as insoluble iron-oxyhydroxide. Bacteria secrete siderophores to chelate iron and transport it into the cell via specific outer membrane receptors. The FhuA receptor protein transports …
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Small molecules that imperfectly replicate protein function of missing proteins restore physiology in yeast and human epithelia
… diseases that are caused by missing protein ion transporters, including cystic fibrosis and microcytic anemia. Like many other human diseases caused by missing proteins, these diseases are difficult to treat, and new approaches are needed. Some small molecules can perform ion transporter-like …
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Isolation, Purification, and Chemical Characterization of the Dihydroxamate-Type Siderophore, "Schizokinen," Produced by <em>Rhizobium leguminosarum</em> IARI 917.
<p>Iron is essential to the majority of microorganisms; it is an important cofactor in many cellular processes and enzymes. However in an aerobic environment and at biological pH, iron is primarily found as insoluble oxyhydroxides and is unavailable to microorganisms. Many bacteria have the ability …
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Development and Evaluation of Brain Tumor Targeted Liposome Delivery System for Paclitaxel
… local and systemic toxicity, problems with transport of the drug across the blood brain barrier (BBB), and a high degree of chemoresistance demonstrated by tumor cells. Newer targeted delivery systems with more specificity for gliomas, improved safety profiles, and an enhanced ability to …
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Modelling the transport of iron-based colloids in saturated porous media
… develop a numerical model able to describe the transport of highly concentrated suspensions of iron particles, in particular during their injection in the subsurface, and in the early stages of migration through the porous matrix. The model is intended to be used as a tool in the development of …