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Showing 1 to 14 of 14 for “"iron regulation"”.
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Molecular and cellular insights into iron regulation
The iron hormone hepcidin is regarded as the main iron homeostatic regulator in the human body. It is predominantly produced by hepatocytes in response to systemic iron excess. However, since the cellular and molecular mechanisms involved in hepcidin expression are not fully understood, this …
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Probing Iron Accumulation in Sacchromyces cerevisiae Using Integrative Biophysical and Biochemical Techniques
Iron is an essential element for life. It is involved in a number of biological processes, including iron sulfur (Fe/S) cluster assembly and heme biosynthesis. However it is also potentially toxic due to its ability to induce formation of reactive oxygen species (ROS) via Fenton chemistry. …
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The effect of iron metabolism on palmitate-induced INS-1 cell death
… 28 10. Measurement of intracellular labile iron pool (LIP) 29 11. Aconitase activity assay 29 12. Oxygen consumption rate (OCR) 30 13. PA uptake 31 14. Quantitation of insulin 31 15. Immunocytochemistry 32 16. Statistics 32 Ⅲ. RESULTS [Part I] 36 A. Palmitate treatment reduces intracellular …
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Ironing Out the Host-fungal Interaction in Airway Epithelial Cells
… on the relationship between innate immunity and iron regulation from the host perspective. The trace element iron is needed by both the fungus and the host for cellular maintenance and survival, but tightly controlled iron regulation in the host is required to prevent oxidative stress and cell …
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Characterization of the Role of Glutaredoxin 3 and Its Binding Partners In Maintaining Iron Homeostasis In Saccharomyces Cerevisiae
<p>The transcription of iron uptake and storage genes in S. cerevisiae is primarily regulated by the transcription factor Aft1. Nucleocytoplasmic shuttling of Aft1 is dependent upon mitochondrial Fe-S cluster biosynthesis via a signaling pathway that includes the cytosolic monothiol glutaredoxins, …
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Magneto-optical studies of RirA and cytochrome cd1
… leguminosarum controls genes involved in iron uptake through repression under conditions of iron sufficiency. This part of iron regulation is co-ordinated by the dimeric rhizobial iron regulator, RirA. The sequence of RirA contains four cysteines in close proximity, three of which have …
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Measuring Brain Iron In Healthy Controls And Accessing Venous Abnormalities In Parkinson's Disease Using Mri
<p>Iron plays a key role in a number of brain cellular processes. However, abnormal brain iron regulation correlates with a number of neurodegenerative diseases such as Parkinson's disease, multiple sclerosis and so forth. To further elucidate the involvement of iron in neurodegenerative disorders, …
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Investigating Iron Transport and Utilization Features of Acinetobacter baumannii
… infections. The bacterium must overcome iron starvation and oxidative stress conditions imposed by the host in order to propagate and cause disease. This work further investigates the transport and utilization of iron by <i>A. baumannii</i>, and their involvement in virulence. The …
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A Mathematical Model of the Iron Regulatory Network in Aspergilus Fumigatus
… as other invasive fungal infections, are poor. Iron has been shown to be essential for Aspergillus fumigatus virulence. Furthermore, mechanisms in the iron regulatory network are believed to be potential drug targets since iron management in fungi is vastly different from that in mammals and …
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THE SUBTLE BIOFILM REGULATION IN ESCHERICHIA COLI: CSGD AND THE YDDV-DOS OPERON
… in E. coli biofilm formation in response to environmental signals and on regulation of curli fibers, cellulose and poly-N-acetylglucosamine (PNAG), the most important biofilm determinants in E. coli. E. coli is an Enterobacterium, normally living inside the mammalian gut, at temperature of 37° C …
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Systems Genetics and Systems Biology Analysis of Paraquat Effects in BXD Recombinant Inbred Mice
… it is the result of the interaction between environmental factors and genetic susceptibility. Increasing evidence led us to infer a relationship between iron metabolism in the brain, environmental toxicants like paraquat, and sPD. Our hypothesis is that variable genetic factors contribute to …
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Characterization of Complex Transcriptional Regulation Within the YQJH-YQJI Intergenic Region
<p>Iron is an essential cofactor for many biological processes. Due to the potential toxicity of iron as a result of Fenton chemistry, iron homeostasis in humans and other mammals is tightly controlled; this leaves only minute amounts of free iron available to invading pathogenic bacteria. This …
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Hemin Acquisition in Bartonella quintana
… indicate several potential uptake systems and iron-responsive regulators. Transcription of the <i>hbp</i> genes (hemin binding protein genes) is responsive to alterations in available hemin and an HbpA homolog in <i>B. henselae</i> reportedly functions as a hemin receptor in <i>E. coli hemA</i> …
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Hemin Acquisition in Bartonella quintana
… indicate several potential uptake systems and iron-responsive regulators. Transcription of the <i>hbp</i> genes (hemin binding protein genes) is responsive to alterations in available hemin and an HbpA homolog in <i>B. henselae</i> reportedly functions as a hemin receptor in <i>E. coli hemA</i> …