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Showing 1 to 20 of 49 for “"iron metabolism"”.
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The Regulation of Cellular Iron Metabolism
Iron is essential for life, but it presents a challenge to our cells because of its ability to drive free radical formation that damages proteins, lipids and DNA. While the consequences of iron excess or deficiency for disease are well described, it has only been recently recognised that …
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The effects of quercetin on iron metabolism
… known to be major inhibitors of dietary non-haem iron bioavailability, mainly through their action as iron chelators. In this present study Caco-2 cells were used to investigate the influence of quercetin, the most abundant flavonol in the diet, on non-haem iron bioavailability using 55Fe, and the …
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The regulation of human iron metabolism in hypoxia
… Altitude exposure enhances erythropoiesis and iron-dependent oxidative and glycolytic enzyme production, for this reason, athletes must maintain a healthy iron balance at altitude. A negative iron balance at altitude may limit such physiological adaptations, potentially reducing the performance …
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Biogenesis of iron-sulfur clusters and intracellular iron metabolism
Iron-sulfur ([Fe-S]) clusters represent one of natures most diverse and ubiquitous protein prosthetic groups. [Fe-S] proteins are integral for diverse biological processes. Reconstitution of apo-proteins can occur by exogenously adding excess iron and sulfide. However, due to the toxicity of iron …
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Crosstalk Signaling Between Circadian Clock Components and Iron Metabolism
… organism's behavior and physiology with the environment. Many metabolites utilized in metabolic processes seem to follow a pattern of circadian oscillation. Iron, an essential component in cellular processes such as respiration and DNA synthesis, is obtained almost exclusively through diet, yet …
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Effects of carbohydrates on iron metabolism in intestinal and liver cells
Iron deficiency and excess are worldwide public health problems. Studies suggest that carbohydrates such as fructose, and oligo-and polysaccharides (prebiotics), increase iron bioavailability, but results are inconclusive. There is also interest in whether iron and fructose contribute to the …
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Investigation into the causal effect of iron metabolism on cardiovascular disease
Background: The iron-heart hypothesis, put forward in 1981, proposes that higher iron levels are responsible for an increased risk of cardiovascular disease in men and post-menopausal women compared to pre-menopausal women. However, despite 30 years of research into this suggested association, …
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The effects of exercise on iron metabolism in adult female rats
The effects of exercise training and iron intake on iron metabolism in adult female rats were investigated. Adult female Sprague-Dawley rats were assigned to either an exercise (E) or sedentary (S) group and fed either a diet containing 9 ppm (9) of dietary iron (low iron level), or 40 ppm (40) of …
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The effect of iron metabolism on palmitate-induced INS-1 cell death
… 28 10. Measurement of intracellular labile iron pool (LIP) 29 11. Aconitase activity assay 29 12. Oxygen consumption rate (OCR) 30 13. PA uptake 31 14. Quantitation of insulin 31 15. Immunocytochemistry 32 16. Statistics 32 Ⅲ. RESULTS [Part I] 36 A. Palmitate treatment reduces intracellular …
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UPPER MOTOR NEURON BURDEN IN AMYOTROPHIC LATERAL SCLEROSIS: CLINICAL AND IMAGING FEATURES, AND THE ROLE OF IRON METABOLISM
… stato preso in considerazione in particolare il metabolismo del ferro, poiché coinvolto in particolare nella degenerazione della via motoria centrale. Studi post mortem sui pazienti hanno dimostrato che l’accumulo di ferro intracellulare cerebrale è presente nelle medesime aree corticali che in …
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Development and validation of quantitative methods for the analysis of clinical biomarkers of iron metabolism applying stable isotopes
… diseases associated with disorders of the iron metabolism affect a significant proportion of the population, especially in the case of iron deficiencies (e.g. Fe-dependent anemia) as well as iron overload (e.g. hereditary hemochromatosis). In 2001, a liver-synthesized peptide hormone called …
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Elucidating the role of Mitoferrin (Mfrn), Iron Regulatory Proteins (IRP1 and IRP2) and Hephaestin (Heph) in Iron Metabolism by tagSNP and Protein-Protein Interaction (PPI) analysis
Precisely how Hephaestin (Heph) facilitate iron release from cells is poorly understood. The work in this thesis tried to establish the role of different iron metabolic proteins, Mitoferrin (Mfrn), IRPs and Heph in iron homeostasis. Analysis of 18 tagSNPs in the Mfrn gene was carried out in an …
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Effects of exercise and protein nutriture on the iron status of rats at selected intervals of gestation
… of two levels of dietary protein and exercise on iron metabolism in pregnant Sprague-Dawley rats was studied. Animals were assigned to the following diet and exercise groups on the first day of gestation: high protein sedentary (HS), high protein exercise (HEx), low protein sedentary (LS), low …
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The regulation of the hepcidin by modulators of the bone morphogenetic protein (BMP) pathway
Hepcidin, the iron regulatory peptide, has emerged as the master regulator of systemic iron homeostasis. Under normal circumstances, hepcidin expression is upregulated by excess iron and inflammation; and downregulated by iron deficiency, anaemia and hypoxia. Insights gained into the pathogenesis …
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NONHUMAN PRIMATES AS A TRANSLATIONAL MODEL OF ENDOMETRIOSIS AND ITS EFFECTS ON WOMEN'S HEALTH
… lesions are characterized by excess iron content and macrophage infiltration. Despite decades of endometriosis research, little is known about macrophage contribution to disease progression or the systemic effects of endometriosis on other physiologic processes. The project objectives …
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Identification and Characterization of a Suppressor Mutation That Relieves the Enzymic and Growth Defects of Sod-Deficient Escherichia Coli
… SOD-deficient strains are somewhat starved for iron, and the iron-binding ability of these dipicolinates caused the Fur (iron uptake) regulon to be derepressed in the suppressed strains. However, a fur mutation only partially relieved the auxotrophies, indicating that Fur derepression assists …
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