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Showing 1 to 9 of 9 for “"iron deposition"”.
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Measuring Brain Iron In Healthy Controls And Accessing Venous Abnormalities In Parkinson's Disease Using Mri
<p>Iron plays a key role in a number of brain cellular processes. However, abnormal brain iron regulation correlates with a number of neurodegenerative diseases such as Parkinson's disease, multiple sclerosis and so forth. To further elucidate the involvement of iron in neurodegenerative disorders, …
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Imaging Iron Content In Patients With Multiple Sclerosis Using Magnetic Resonance Imaging
<p>The importance of iron in maintaining normal physiological processes in the human body has been well emphasized in the literature. However, "when iron behaves badly", its abnormal presence might lead to a spectrum of pathologies depending on what function has been altered. In the brain, for …
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Ferritin: Mechanistic Studies and Electron Transfer Properties
Ferritins are ubiquitous iron storage proteins in living systems. Although much is known about the iron deposition process in ferritin and a mechanism has been developed, several important issues still remain unknown. One lingering question is the less than stoichiometric quantities of hydrogen …
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Interplay of Iron and Hydrogen Sulfide in Pathophysiology of Vascular Damage
Hydrogen sulfide (H₂S) and iron are fundamental regulators of redox biology, exerting opposing influences on oxidative stress and vascular homeostasis, yet their mechanistic interplay remains unresolved. This dissertation addresses this gap through a series of studies spanning molecular, …
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The Effect of Iron Overload on the Long-term Toxicological Effects of Fumonisin B1 in Rat Liver
The long-term toxicological effects of hepatic iron overload on the cancer initiating and promoting properties of fumonisin B1 (FB1) were investigated in male Fisher 344 rats. An initial pilot (dose response) study over 15 weeks was performed to determine a level of dietary iron that achieves a …
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Quantification of Localized Brain Iron Sources Using Magnetic Resonance Phase
… BMB present a source of potentially cyctotoxic iron to the brain proportional to the amount of extravasated blood, non-invasive quantification of this iron pool is potentially valuable both to assess tissue risk and as a biomarker to monitor disease progression, treatment efficacy, and inform …
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Hinokitiol restores hemoglobinization and mitigates neurodegeneration in animals by re-establishing iron homeostasis
Iron misdistribution disorder is characterized by iron accumulation and iron deficiency in various sites due to ferroportin (FPN1) dysfunction. Genetic FPN1 deficiency causes Ferroportin disease (FD), which is characterized by iron deposition in liver macrophages and anemia. Aside from …
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Biological Clocks, Inflammation, and Multiorgan Damage In Sickle Cell Disease
… in sickle lung, which include heme and iron homeostatic genes and inflammatory genes. Unexpectantly, I also discovered an increased expression of rhythmic genes in SCD lung. <em>Period 2</em> <em>(Per2)</em>, a circadian gene, was increased in SCD. To test whether<em> Per2</em> mRNA and …
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Quantitative susceptibility mapping and susceptibility-based distortion correction of echo planar images
… susceptibility maps from acquired fieldmaps. Iron deposits change the susceptibility of tissue, resulting in magnetic perturbations that are detectable with high resolution fieldmaps. Excessive iron deposition in specific regions of the brain is associated with neurodegenerative disorders such …