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Showing 1 to 9 of 9 for “"iridoid"”.
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A Catharanthus roseus mutant with trace levels of secologanin and monoterpenoid indole alkaloids does not express BIS1/BIS2 transcription factors and fails to activate iridoid biosynthesis.
… agents. Most of the alkaloid and pre-alkaloid iridoid pathway has been elucidated, but some critical areas remain uncharacterized. The early iridoid pathway is localized to internal phloem associated parenchyma (IPAP) cells, with the latter part of the pathway localized to the epidermal cells …
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Functional Characterization of Monoterpenoid Indole Alkaloid (MIA) Biosynthetic Genes in Catharanthus roseus
… MIAs are derived by combining the iridoid secologanin with tryptamine to form the central precursor strictosidine that is then converted to most known MIAs, such as catharanthine and vindoline that dimerize to form anticancer vinblastine and vincristine. While their assembly is …
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Isolation and Structure Elucidation of Cytotoxic Natural Products from the Rainforests of Madagascar and Suriname
… extracts from Cerbera manghas yielded a known iridoid and a known cardiac glycoside, both of which showed good bioactivity. The cytotoxicity associated with the iridoid is unprecedented, and it also was further evaluated by the NCI. An extract of a Cordia species yielded two known compounds - a …
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Phytochemical investigation and biological activities of Sanicula europaea and Teucrium davaeanum. Isolation and identification of some constituents of Sanicula europaea and Teucrium davaeanum and evaluation of the antioxidant activity of ethanolic extracts of both plants and cytotoxic activity of some isolated compounds
… 6 is a phenylethanoid glycoside and 8 is an iridoid glycoside, from the data available these may be new compounds for which the names davaeanuside A and davaeanuside B are proposed respectively." The total polyphenol content of S. europaea L, T. davaeanum leaves-flowers and T. davaeanum stem …
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Understanding and manipulating alkaloid biosynthesis
… form 10-oxogeranial, which is the substrate for iridoid synthase, the reductive cyclase that assembles the characteristic iridoid scaffold. Despite having an incomplete understanding of MIA biosynthesis, several engineering strategies have been successfully deployed to incorporate halogenation …
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Discovery, characterization, and rational design of the enzymes involved in monoterpene indole alkaloid biosynthesis in Madagascar periwinkle
… Spengler condensation of tryptamine and the iridoid monoterpene secologanin. This reaction is catalyzed by the enzyme strictosidine synthase. This thesis describes the use of kinetic isotope effects, the rate dependence on pH, as well as structural and computational data to propose a …
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Studies in the Alseuosmiaceae
… abundant in leaf tissue; alkaloids and probably iridoid compounds too, are absent. Tannin is found throughout the ovary tissue of Alseuosmia and in the inner and outer epidermises of the ovular integument. The floral vascular anatomy is detailed for the Alseuosmiaceae and reviewed for eight …
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MECHANISMS OF SUCCESS: PLANT-HERBIVORE INTERACTIONS AND THE INVASION OF NON-NATIVE LONICERA SPECIES IN NORTH AMERICA
… species, native Lonicera tended to produce more iridoid glycosides and non-native Lonicera produced more phenolic compounds. Lonicera maackii and other non-natives appear to not only escape damage from arthropod herbivores, they are also able to tolerate and resist the damage they do incur …