Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"ionotropic glutamate receptors"”.
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Visualizing the dynamics of ionotropic glutamate receptors using atomic force microscopy
Glutamate is the major excitatory neurotransmitter in the mammalian brain. It binds to three different subclasses of ionotropic glutamate receptors (iGluRs): AMPA, kainate and NMDA receptors, and triggers a cation influx that generates synaptic currents crucial to brain function. Significantly, …
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Modulation of The Receptor Gating Mechanism and Allosteric Communication In Ionotropic Glutamate Receptors
<p>Ionotropic glutamate receptors (iGluRs) found in mammalian brain are primarily known to mediate excitatory synaptic transmission crucial for learning and memory formation. The family of iGluRs consists of AMPA receptors, NMDA receptors and kainate receptors with each member having distinct …
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The role of ionotropic glutamate receptors in chronic central pain after spinal cord injury
… \r\n In models of peripheral injury, increased ionotropic glutamate receptor mediated activity results in spinal central sensitization. Extracellular single-unit recordings from all three regions of the spinal cord (lumbar enlargement, thoracic cord, and brachial enlargement) were made on both …
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Effects of Cocaine Sensitization on Drug Self-Administration, Mesocorticolimbic SAPAP Levels, and Prefrontal Ionotropic Glutamate Receptors
… in the mesocorticolimbic system related to glutamate receptors, SAPAPs, and affects drug self-administration. Taking all the previously discussed research studies into consideration, we hypothesized that low-dose cocaine self-administration would yield a significant elevation in drug seeking …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
Glutamate is the major excitatory neurotransmitter in the brain and is crucial for processes such as learning and memory. Due its importance as a signaling molecule, the extracellular glutamate concentration is tightly regulated, largely by the excitatory amino-acid transporters (EAATs). In these …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
Glutamate is the major excitatory neurotransmitter in the brain and is crucial for processes such as learning and memory. Due its importance as a signaling molecule, the extracellular glutamate concentration is tightly regulated, largely by the excitatory amino-acid transporters (EAATs). In these …
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Investigations of The Structure-Function Relationship In Kainate Receptors Using FöRster Resonance Energy Transfer
<p>Kainate receptors belong to the family of ion channels known as the ionotropic glutamate receptors. Ionotropic glutamate receptors mediate the majority of excitatory synaptic transmission, modulate the release of presynaptic glutamate, and facilitate dendrite formation. Kainate receptors are …
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Fret-Based Investigations of The Structure-Function Relationships In The Nmda Receptor
… one member of a class of proteins known as the ionotropic glutamate receptors. Ionotropic glutamate receptors mediate the majority of excitatory neurotransmission in the central nervous system, with the NMDA receptor standing out among these receptors for its requirement of a co-agonist, its …
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Domain-based approaches to understanding phylogeny and orthology
… and functional identification. Two groups of ionotropic glutamate receptors (iGluR’s) were identified with the topology of the binding core and pore-loop of the eukaryotic iGluR’s. Group 1 has a potassium-like selectivity filter and Group 2 is most closely related to eukaryotic iGluR’s. The …
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The Extracellular Domains of the AMPA, Kainate, and Orphan Delta Receptor Regulate Channel Gating in Distinct Ways
<p>The ionotropic glutamate receptors are ligand-gated cationic channels essential for neuroplasticity and neurological functions such as learning, memory, behavior, cognition, and motor coordination. Mutations in these channels are linked to various disorders including autism, ataxia, and …
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An Examination of Hippocampal and Prefrontal Contributions to Spatial Learning and Memory using Immediate Early Gene Imaging
… underlying neuronal activation by inhibiting ionotropic glutamate receptors (NMDA and AMPA) during or after spatial learning. We found novel evidence that the salience (or noticeability) of environmental cues significantly impacted the type of learning strategy used (i.e. simple or complex), …
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A general scaffold for the synthesis of cysiherbaine and its analogues
… have been shown to have selective effects on ionotropic glutamate receptors (iGluRs). iGluRs are essential components in the central nervous system (CNS); playing an important role in memory and learning. They also play a role in a number of neurological disorders, including schizophrenia, …
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The Structural Mechanism of Allosteric Modulation of The Nmda Receptor: A Balance of Tensions
<p>N-methyl-D-aspartate (NMDA) receptors are one of the three main types of ionotropic glutamate receptors in the central nervous system. NMDA receptors mediate the rapid excitatory neurotransmission that underlies learning and memory formation. Conversely, NMDA receptors are implicated in a …
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Assessing the impact of domoic acid exposure on the zebrafish (Danio rerio) brain across life stages
… and wildlife. DA is a structural analog of glutamate - an excitatory neurotransmitter - that activates ionotropic glutamate receptors leading to excitotoxicity and ultimately neurobehavioral defects. While current seafood regulations prevent acute toxicity from high-level exposure, low-level …
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Mouse Models of GRIN1-Related Neurodevelopmental Disorder and Initial Investigations of Endocannabinoid Modulating Treatments
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors formed as tetrameric complexes of two GluN1 subunits plus two copies of GluN2 or GluN3 subunits, or a mixture of both. These receptors mediate excitatory neurotransmission and play critical roles in processes underlying …
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Ampa Receptor Allosterism: Measurement of The Conformational Changes In The Ligand Binding Domain of A Functional Receptor
Ionotropic glutamate receptors are important excitatory neurotransmitter receptors in the mammalian central nervous system that have been implicated in a number of neuropathologies such as epilepsy, ischemia, and amyotrophic lateral sclerosis. Glutamate binding to an extracellular ligand binding …
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Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology
… to higher brain areas, including the thalamus. Glutamate is implicated in the transmission of the nociceptive information and thus an increased understanding of the nature and effects of glutamate receptors activation has major implications in migraine pathophysiology and treatment. Here the …
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Structure-Function and Behavioral Studies on the Glutamate Delta-1 Receptor
The delta family of ionotropic glutamate receptors (iGluRs) consists of glutamate delta-1 (GluD1) and glutamate delta-2 (GluD2) receptors. The function of GluD1 in the central nervous system (CNS) remains elusive. As a first step we conducted electrophysiological studies on the rat clone of GluD1 …
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Identification and functional characterisation of synaptic AMPA receptor-interacting proteins
… release from one neuron acts on the postsynaptic receptors of another, facilitating transfer of electrical impulses between neurons. At glutamatergic synapses, ionotropic glutamate receptors (iGluRs) respond to presynaptically released L-glutamate, the predominant excitatory neurotransmitter. …
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Functional Analysis of Plant Glutamate Receptors
The plant glutamate receptors (GLRs) are homologs of mammalian ionotropic glutamate receptors (iGluRs) and are hypothesized to be potential amino acid sensors in plants. Since their first discovery in 1998, the members of plant GLRs have been implicated in diverse processes such as C/N ratio …
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