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Showing 1 to 15 of 15 for “"ionization methods"”.
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Development Of Inlet And Vacuum Ionization Methods For Characterization Of Biological Materials By Mass Spectrometry
<p>Inlet ionization and vacuum ionization are novel ionization methods to produce electrospray ionization (ESI)-like ions from the solid or liquid states, operating from atmospheric pressure (AP) or vacuum, without the use of voltage or the necessity of high energy input such as a laser or particle …
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Development Of Matrix Assisted Ionization Methods For Characterization Of Soluble And Insoluble Proteins From Native Environments By Mass Spectrometry
<p>Matrix-assisted laser/desorption ionization (MALDI) and electrospray ionization (ESI) have made a huge impact in the analysis of biological materials. ESI has gained its popularity involving liquid based analysis, efficient fragmentation, chromatographic and electrophoretic separations but has a …
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Linear state-space analysis and optimization of StreamIt programs
… two systems that couple sample ion introduction methods with a Differential Mobility Spectrometer (DMS). The sample ionization methods used with a custom designed interface for the DMS were Electrospray Ionization (ESI) and Atmospheric Pressure Matrix Assisted Laser Desorption Ionization …
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Characterization of AP-MALDI and ESI for a differential mobility spectrometer
… two systems that couple sample ion introduction methods with a Differential Mobility Spectrometer (DMS). The sample ionization methods used with a custom designed interface for the DMS were Electrospray Ionization (ESI) and Atmospheric Pressure Matrix Assisted Laser Desorption Ionization …
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Mass Spectrometry-Based Strategies for Biomolecular Structure Analysis: Steroid Metabolites Structures and Protein-Protein Interactions
… focused on small molecules, owing to the limited ionization methods which posed difficulties in producing gas-phase ions for large biomolecules then. Beginning in the 1980's, with the introduction of new ionization methods (ESI and MALDI), the applications have gradually switched to biological …
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MASS SPECTROMETRIC STUDIES ON PETROLEUM ASPHALTENES AND ORGANOSULFUR COMPOUNDS, ON FUNCTIONAL-GROUP SELECTIVE ION-MOLECULE REACTIONS AND ON GAS-PHASE REACTIVITY OF META-BENZYNES TOWARD AMINO ACIDS
… mixture analysis. When coupled with separation methods, such as gas chromatography or high performance liquid chromatography, analysis of minor components in complex mixtures is possible. In addition to the molecular weight information, mass spectrometers can provide structural information for …
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Laser-Ionization Time-of-Flight Mass Spectrometry of High Molecular Mass Inorganic Complexes
Laser-Ionization Time-of-Flight Mass Spectrometry (LI-TOF-MS) is a sophisticated tool for the molecular-weight determination and structural characterization of a variety of molecules. Advances in instrumentation and ionization methods have recently expanded its role in the analysis of high-mass …
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Analysis of membrane systems using lipoprotein nanodiscs
… membrane proteins and lipids with bioanalytical methods, including mass spectrometry and photonic biosensors. Mass spectrometry offers several powerful techniques for fundamental characterization of Nanodiscs and Nanodisc-solubilized membrane proteins. Native mass spectrometry delivers …
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Development of a quadrupole ion trap / time-of-flight mass spectrometer for mass resolution and ion photophysics
… Ions are generated externally by electrospray ionization and trapped in the quadrupole ion trap before extraction to the time-of-flight section for mass analysis. The non-parallel fields in the hyperbolic ion trap, which serves as the first acceleration region in the time-of-flight mass …
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Protein Set for Normalization of Quantitative Mass Spectrometry Data
… and quantitation. With the advent of soft ionization methods, such as electrospray ionization and matrix assisted laser desorption/ionization, mass spectrometry has opened a new era for protein and proteome analysis. Due to its high-throughput and high-resolution character, along with the …
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Experimental and theoretical investigations of molecular ions by spectroscopy as well as ion mobility and mass spectrometry
… of this thesis was the elucidation of different ionization methods (resonance-enhanced multiphoton ionization – REMPI, electrospray ionization – ESI, atmospheric pressure chemical ionization – APCI) in ion mobility (IM) spectrometry. In order to gain a better understanding of the ionization …
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Characterization of Cucurbituril Complex Ions in the Gas Phase Using Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
… coupled with high-level computational methods becomes a powerful tool to elucidate binding behavior in host-guest complexes. With rigid, symmetric structures available in a range of sizes, cucurbiturils have been ideal prototypical host molecules in host-guest chemistry since they were …
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Investigation of mass spectrometric interfaces for supercritical fluid chromatography and liquid chromatography
… thermal lability of these compounds conventional ionization methods (EI, CI) are not suitable. Factors which have ramification on sample handling (flow rate, solution composition) were studied. The high sample flow rate capability was dependent on effective nebulization and desolvation. Thus, …
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Direct drug screening and lipid profiling using ambient mass spectrometry
… the performance of conventional spray-based ionization methods always suffers from chemical interferences derived from complex biological matrices. A series of sample extraction, purification, and separation steps is required before the ionization, so as to ensure excellent performance of MS …
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Mass Spectrometric Studies on the Primary Products of Fast Pyrolysis of Carbohydrates and the Molecular Structures of Asphaltenes, and the Development of a Rastering Probe for Laser-Induced Acoustic Desorption into an Atmospheric Pressure Chemical Ionization Source
… it does have limitations. Traditional GC/MS methods used for the analysis of fast pyrolysis products cannot be used to analyze the primary products, thus limiting the knowledge that can be obtained regarding the true mechanisms of fast pyrolysis, ultimately restricting the level of control …