Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"ion homeostasis"”.
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Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury
… that contributes to cell death. Whether zinc ions are toxic or protective in TBI is controversial. As an essential human micronutrient, zinc is needed for the structure and function of at least 3,000 proteins, and thus affects almost any aspect of cellular function. Although extremely low, …
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An investigation of the role of Arabidopsis thaliana plant natriuretic peptide in planta
… to survival is the maintenance of water and ion homeostasis. The mechanisms by which plants achieve this are poorly understood. Traditionally plant stress responses were thought to be communicated by five classical plant hormones - auxin, cytokine, gibberellic acid, absisic acid and ethylene. …
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Mechanisms Underlying Variation in Insect Chill Tolerance: The Role of Ion and Water Transport
Water and ion homeostasis has emerged as an important factor limiting chill-susceptible insects at low temperatures; loss of this homeostasis in the cold likely contributes to chronic chilling injury, and reestablishment of homeostasis is required for recovery from chilling. Both plastic and …
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Elucidating the biology of G-protein coupled receptor 35
… coupled receptor which has attracted attention as a coding variant is linked to primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). GPR35 is also upregulated in numerous cancers. Multiple studies of GPR35 have so far fallen short of revealing its core biology. In this project …
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Effects of MDGA2 Reduction on Synaptic Long-Term Depression and Development in Male Mice
… by inhibiting neurexin-neuroligin adhesion complexes and BDNF/TrkB signaling. Mdga2+/- mice, modeling autism-associated mutations, show increased excitatory synapse density and hyperexcitation in adulthood, resulting in altered hippocampus-dependent cognition and plasticity. Despite the …
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Investigating the molecular mechanism whereby auxin modulates Arabidopsis thaliana growth under salinity stress conditions
Soil salinization is detrimental to plant growth and yield, and an increasing global problem in irrigated agricultural land. Salinity imposes both an osmotic and ionic stress on plants, the latter of which is unique to salt stress. Previous work has indicated that the plant growth hormone auxin …
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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
… cells are particularly sensitive to perturbations in ion homeostasis, especially when ion gradients are perturbed in combination with MAP kinase inhibition. I hypothesized that melanoma cells preferentially require certain ion channels and transporters for growth and survival. I thus screened …
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With No Lysine 1 (WNK1): A Potential Regulator of The Lysosomal Degradation Pathway
… kinase that has its catalytic lysine positioned in a unique location. This kinase, along with another member of the WNK family, WNK4, has been genetically linked to pseudohypoaldosteronism type II (PHAII), which is characterized by both hypertension and hyperkalemia. Several groups have …
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Crystallographic studies of the metal-responsive transcription factor NikR
Metal ion homeostasis is critical to the survival of all cells, because requirements for these essential nutrients must be balanced with their toxicity when present at elevated concentrations. Regulation of nickel concentrations in Escherichia coli is achieved via nickel-induced transcriptional …
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Studies into Mg-preconditioning of brewer’s yeasts
… cells, which were physiologically “preconditioned” with Mg ions, had improved fermentative output and stress tolerance. Ale and lager yeast cells preconditioned in the presence of elevated levels of Mg-actate, yielded highest cellular Mg contents in malt extract broth and dilute brewer’s wort …
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Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
… events that regulate trafficking and fusion of micronemes with the plasma membrane remain unresolved. In this thesis, I describe the discovery and characterization of a regulator of microneme exocytosis in Toxoplasma gondii. In the first chapter, I introduce T. gondii as a model …
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Mitochondrial parts, pathways, and pathogenesis
… perform essential roles in energy metabolism, ion homeostasis, and apoptosis. Mitochondrial dysfunction causes disease in 1 in 5,000 live births and also has been associated with aging, neurodegeneration, cancer, and diabetes. To systematically explore the function of mitochondria in health and …
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Establishing Intratumoral Modulation Therapy as a New Treatment Modality for High Grade Gliomas
… treatments with surgery and chemo-radiation. Advances in electrotherapeutics offer a foundation for developing new treatment modalities that exploit an innate vulnerability of glioblastoma (GBM). Low intensity, non-ablative electric fields are innocuous to normal neural structure, but …
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Predicting Vision Loss In Healthy Aging With Manganese-Enhanced Mri Of The Rat Eye
<p>In healthy aging, visual function declines throughout adulthood. Age-related changes in neuronal ion homeostasis -- specifically, increased Ca2+ influx through L-type voltage gated calcium channels (L-VGCCs) -- are believed to contribute to certain functional declines, but this possibility has …
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Ankyrin-B and Mtor Complex 1 In The Regulation of Electrical Activities In The Heart
… 1 (mTORC1) activity is paramount in the regulation of electrical activities in the brain and the heart. In the brain, the tumor suppressor gene <em>TSC2</em> encodes the protein product tuberin that interacts with hamartin to form a heterodimer Tuberous Sclerosis Complex (TSC) that regulates …
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Proteomic Profiling of the mdx Animal Model for Duchenne Muscular Dystrophy
… cytoskeletal protein dystrophin and the reduction of its associated glycoprotein complex, secondary alterations in cellular signalling, ion homeostasis regulation and metabolic pathways lead to fiber degeneration and subsequent fibrosis. These changes result in loss of ambulation and sufferers …
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Identification and characterisation of novel marker proteins involved in X-linked muscular dystrophy
… lies with the loss of dystrophin and reduction of its associated glycoprotein complex, secondary alterations in metabolic pathways, cellular signalling and ion homeostasis regulation cause fibre degeneration leading to severe muscle weakness. Skeletal muscle deteriorates to the extent that …
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Differential Regulation of Phosphatidylinositol 4-Phosphate 5 Kinase Beta during Hypertonic and Oxidative Stress
… phosphoinositides account for only a small fraction, yet they play an indispensable role in regulating cellular homeostasis. The phosphatidylinositol derivative, PI(4,5)P2 (PIP2)is an essential mediator of cellular processes such as signal transduction, membrane traffic, actin cytoskeleton, ion …
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METAL TRAFFICKING DURING LIMITATION AND EXCESS IN BACILLUS SUBTILIS
Metal ions are essential for maintaining cellular life, as they are used as cofactors in many reactions and can be utilized as structural components of proteins. Metal ions are so important to bacteria that sequestering these metals is an antibacterial strategy employed by vertebrate immune …
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The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels
… cytosolic Ca2+ levels remain high, cellular functions are disrupted, which is associated with initiation of pancreatitis. Ca2+ signals are achieved through regulating endoplasmic reticulum (ER) stores, Ca2+ATPases, and store-operated Ca2+ entry (SOCE). However, how these pathways interact to …
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