Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"iodoacetate"”.
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Chondroprotective action of tart cherry in the monosodium iodoacetate (MIA) rat model of osteoarthritis
… effects of whole tart cherry in a monosodium iodoacetate (MIA) induced rat model of osteoarthritis (OA). Methods: A total of forty, 45-day-old female CD rats were used for study. Thirty rats were injected with MIA to induce joint destruction and randomized into three groups of 10 animals each. …
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Chondroprotective action of tart cherry in the monosodium iodoacetate (MIA) rat model of osteoarthritis
… effects of whole tart cherry in a monosodium iodoacetate (MIA) induced rat model of osteoarthritis (OA). Methods: A total of forty, 45-day-old female CD rats were used for study. Thirty rats were injected with MIA to induce joint destruction and randomized into three groups of 10 animals each. …
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Anti-inflammatory and joint-protective effects of blueberries in a monosodium iodoacetate (MIA) induced rat model of osteoarthritis
… The in vivo study design employed a monosodium iodoacetate (MIA) induced rat model of osteoarthritis. Forty, 45-day-old female CD rats were used where thirty rats were injected with MIA to induce joint destruction associated with osteoarthritis and ten rats served as control without induction of …
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Demonstration and quantitation of lactate in oxidative and glycolytic fibers of skeletal muscles
… caffeine or high potassium stimulation, and iodoacetate inhibition of glycolysis), both peaks are identified as lactate.
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Characterization of the meta-cleavage pathway enzymes, 4-Hydroxy-2-ketovalerate aldolase and aldehyde dehydrogenase (acylating), from Pseudomonas sp. strain CF600
… Finally, chemical modification of the enzyme by iodoacetate provided evidence for the involvement of a reactive cysteine residue in dehydrogenase, but not aldolase, activity. This result is consistent with postulated mechanisms of other aldehyde dehydrogenases, and will allow creation of a …
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Non-Invasive Detection of Anaerobic Metabolism in Exercising Muscle Using Proton MRI
… Isolated frog gastrocnemii were treated with iodoacetate (IAA; to inhibit lactate production), NaCN (to maximize lactate production), or left untreated and then performed 60 1s/min maximal isometric contractions. The intracellular transverse relaxation time (T2,I increased more in NaCN-treated …
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Probiotic characterization of Bifidobacterium spp. isolated from commercial fermented milk in the UK
… lithium salt (TOS- MUP) and Bifidobacterium iodoacetate medium 25 (BIM-25). Considering selectivity of the medium, recovery of the bifidobacteria and ease of preparation, it was concluded that TOS-MUP is the medium of choice for determination of total viable counts of bifidobacteria in …
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Characterisation of Mefloquine accumulation in Plasmodium falciparum
… and is inhibited by the glycolysis inhibitor, iodoacetate, and also by incubation at low temperature. Mefloquine accumulation was also found to be partly dependent on the pH gradient between the acidic food vacuole and the external medium. It has also been determined that mefloquine-resistant …
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The chemistry of thujone : new enantioselective syntheses of Ambrox[Registered trade mark] and Epi-Ambrox
… %. Stereoselective alkylation of 172 with ethyl iodoacetate yielded compound 201exclusively with entry of the side chain in an axial orientation. Hydrogenation of 201 to205 and then ketalization, afforded 215. Reduction of the ester, protection of the alcohol functionality, and deprotection of …
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Astrocytic communication and cell death during metabolic depression and oxidative stress
… depression we used the glycolytic blocker iodoacetate (IA) in primary astrocyte cultures. This treatment induced a reproducible and concentration-dependent ATP decrease which was associated with a profound increase in the activity of reactive oxygen species (ROS). This suggests that …
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Post-translational processing of proteins implicated in the pathogenesis of Alzheimer's disease.
… by alkylation of the reduced bonds with sodium iodoacetate. Microwaving of sections also enhanced immunolabelling, by a mechanism that was additive to reduction and alkylation. Incubation with 80% formic acid did not increase immunolabelling. KPI-containing protein distribution in normal and AD …
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Control of glucose and xylose utilization by Clostridium thermohydrosulfuricum Rt8.B1
… by the reduction of glucose and xylose uptake by iodoacetate and sodium fluoride, both inhibitors of ATP synthesis. The phosphorylation of glucose was carried out by a constitutive ATP-dependent glucokinase and that of xylose by an inducible ATP-dependent xylulokinase following isomerization by …