Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 209 for “"invasiveness"”.
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Defect of Mitochondrial Translation Machinery Enhances Hepatoma Cell Invasiveness
… Claudin-1 regulates Mt-TMD-induced hepatoma cell invasiveness. 26 6. Impact of doxycycline on gene expression 30 IV. DISCUSSION 33 V. CONCLUSION 36 REFFERENCE 37 국문요약 43
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Modelling and empirical approaches for predicting the invasiveness of alien species.
Biological invasions are a pervasive aspect of global change that result from the release of alien species into novel environments. Where an introduced alien establishes a sustainable population, disperses and impacts native species then it is considered as invasive. Predicting the outcomes of …
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Effect of Interstitial Fluid Flow and Radiotherapy on Glioblastoma Invasiveness and Progression
… that radiation contributes to increased invasiveness of glioma. Although the effect of radiation on cells has been studied extensively, its effect on the transport of fluid is not well characterized. Transport in the brain which has significant roles in physiology, GBM pathophysiology, …
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"Interactions and invasiveness of melanomatous human tumor cells within the blood brain barrier endothelium".
Brain metastases occur in about 25% of patients who die of cancer.One of the most common sources of brain metastases in adults is cutaneous melanoma.The malignant potential of melanomatous cell and its adhesion to the cerebral endothelium plays a key role in this process.The aim of this study was …
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Investigation of the effect of disulfiram on the chemoresistance and invasiveness in pancreatic cancer cells
… of hypoxia on the stemness, chemosensitivity and invasiveness of Panc-1, a PDAC cell line, and a panel of patient-derived PDAC primary cultures was investigated. The sphere-cultured PDAC cells contained high hypoxic population which demonstrated CSC/EMT traits and were resistant to the first line …
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Investigation into the potential invasiveness of the exotic Narrow-leaved Bittercress, (Cardamine impatiens L.), Brassicaceae
Exotic species often invade new areas and displace native species. The problems associated with such invasions are well known, but for many exotic species, experimental work has not yet been done to predict which, and under what conditions they may become a problem. Two greenhouse experiments were …
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Role of XRCC3 in Acquisition and Maintenance of Invasiveness through Extracellular Matrix in Breast Cancer Progression
Acquisition of invasiveness through extracellular matrix is a crucial characteristic of transition to malignancy in the breast. It was previously shown that Polo-like kinase 1 (PLK-1), a mitotic kinase and genome stability regulator, is involved in acquisition of invasiveness in a breast cell model …
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Temporal trends in stream-fish distributions, and species traits as invasiveness drivers in New River (USA) tributaries
Biological invasions represent both an urgent conservation problem and an opportunity to advance ecological theory. Development of pertinent research questions and proactive management strategies require knowledge of which introduced species are present and of spatiotemporal trends in the …
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Functional divergence between Vachellia and Senegalia could underpin differences in invasiveness and Eltonian niche partitioning in African savannas
… which could explain the observed differences in invasiveness between them. This thesis provides the first ecophylogenetic study to assess the level of ecological niche divergence between these economically, socioeconomically and ecologically important tree genera in Africa. I address this …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
The p75 neurotrophin receptor (p75NTR) is a member of the tumour necrosis factor superfamily, which relies on the recruitment of cytosolic protein partners - including the TNF receptor associated factor 6 (TRAF6) E3 ubiquitin ligase - to produce cellular responses such as apoptosis, survival, and …
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MECHANISMS BY WHICH XRCC3 MEDIATES BREAST CANCER CELL INVASION VIA CYCLOPHILIN A
… (XRCC3), has been shown to increase breast cell invasiveness. This raises the question of whether XRCC3 is a positive modulator of invasion or whether overexpressed XRCC3 is trapped in non-functional complexes, resulting in a dominant negative effect. To address this we transiently downregulated …
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The role of Mullerian differentiation in epithelial ovarian carcinogenesis
… phenotype of early ovarian neoplasms alters invasiveness, we established the first permanent cell line for serous borderline ovarian tumors (SBOT), which are differentiated but noninvasive. The results revealed a striking phenotypic similarity between two lines regardless of their cytogenetic …
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Effect of mitochondrial respiratory defecton hepatocellular carcinoma :Involvement of mtOGG1 and NUPR1
… to identify major genes to control hepatoma cell invasiveness in response to mitochondrial respiratory defects. To address this, cDNA microarray was performed using SNU hepatoma cells with and without mitochondrial defects. Interestingly, functional enrichment analysis showed that 1423 commonly …
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The Role of TBX3 In Early Breast Cancer Progression
… cancer context. Both TBX3 isoforms induced invasiveness and an epithelial-to-mesenchymal (EMT) phenotype. Coupling data from genome-wide ChIP-array and RNA-Seq studies provided a novel list of genes regulated by each isoform. Both TBX3 isoforms regulate expression of several EMT-related …
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Expression of Epidermal Growth Factor Receptor in hypopharyngeal cancer and Effect of EGF in Progression of hypopharyngeal cancer
… EGF of 10ng/㎖ or 30ng/㎖ for 24 hours. Tumor cell invasiveness was assessed by the membrane invasion assay. RT-PCR and zymography were performed to examine the roles of matrix metalloproteinase-2(MMP-2) and MMP-9, as well as the relationship between EGF and MMPs in FaDu invasiveness. Results: The …
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In vitro investigation of the effect of disulfiram on hypoxia induced NFκB, epithelial to mesenchymal transition and cancer stem cells in glioblastoma cell lines
… cells manifested GSC traits, chemoresistance and invasiveness. These results suggest that hypoxia is responsible for GBM stemness, chemoresistance and invasiveness. GBM cells transfected with nuclear factor kappa B-p65 (NFκB-p65) subunit exhibited CSC and EMT markers indicating the essential role …
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System architecture analysis and selection under uncertainty
… 3. Introduction of the concept of Technology Invasiveness through the use of a component Delta Design Structure Matrix (ADSM). The component DSM is used to evaluate the changes in the DSM due to the technology insertion. Based on the quantity and type of these changes a Technology Invasiveness …
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Investigating aneuploidy's role in cancer cell fitness under various conditions of stress
… proliferation, anchorage-independence, and invasiveness in aneuploid CRC cells versus their diploid counterpart when grown under various culture conditions, including regular media, serum-free media, cytotoxic drug-containing media, and hypoxia. We found that aneuploid cells proliferated …
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TRANSFORMATION OF PRIMARY HUMAN HEPATOCYTES IN HEPATOCELLULAR CARCINOMA
… and CD-44 positivity were tested. The degree of invasiveness of cells acquiring neoplastic characteristics was studied with a trans-well migration assay. We observed that HCC cells maintained their morphology and unmodified neoplastic characteristics when cultured. Cells isolated from CP, showed …
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