Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"invasive growth"”.
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Integrin-Mediated Mechanotransduction Controls Activation of Yap and Invasive Growth of Breast Cancer
… integrin-mediated mechanotransduction controls invasive growth of breast cancer cells in stiff matrices through activation of FAK and YAP. Mechanistic studies revealed that integrin signaling induces - via activation SFKs - tyrosine phosphorylation and inactivation of LATS1 and MOB1. The ensuing …
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Αvβ8 Integrin Interacts With Rhogdi1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion
… cancer glioblastoma multiforme (GBM) displays invasive growth behaviors that are major impediments to surgical resection and targeted therapies. Adhesion and signaling pathways that drive GBM cell invasion remain largely uncharacterized. Here we have utilized human GBM cell lines, primary …
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Multiscale Mathematical Modelling of Cancer Invasion
… has investigated the complex process of cancer growth and spread that occur across several different spatial scales, in order to gain a better understanding of the key processes involved during invasion. At first, we tested our modelling concept by applying a level-set method to a moving …
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Protein Kinase A Regulates Hyphal Growth by Relieving the Interaction of MoSfl1 with the Cyc8-Tup1 Co-repressor in Magnaporthe oryzae
… recognition, appressorium turgor generation, and invasive growth. Two genes in M. oryzae named CPKA and CPK2 encode the catalytic subunits of cAMP-dependent protein kinase A. Previous studies have shown that deletion of CPKA failed to block response to exogenous cAMP, suggesting the involvement of …
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Gene and Protein Expression in Human Gliomas
… a rapid fatal progression for the patient. The invasive growth pattern and inherent resistance to radiation and chemotherapy account for a lack of efficient therapies. Several novel therapeutic regimes are being investigated, but they have so far shown limited beneficial effects. The molecular …
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S100A4 regulation and function
… membrane ruffling and a reduction in invasive growth in three-dimensional culture. My data suggest that interaction of S100A4 and Rhotekin alters the functional output of Rho signaling to confer an invasive phenotype in breast cancer cells. In summary, this dissertation highlights the …
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Die differentielle Expression tumorfördernder und tumorinhibierender Gene im ersten und zweiten Trimester der Schwangerschaft
… the fetal gas exchange and nutrient supply. Invasive growth of these trophoblast cells is greatest in the first trimester of pregnancy and subsides at the beginning of the second trimester. This behavioural change in trophoblast activity appears to be a strictly regulated process. At present, …
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Utilizing in vivo genome-wide CRISPR/Cas9 screens in immunocompetent mouse models to identify novel tumor liabilities and explore mechanisms of resistance to Chimeric Antigen Receptor T-cell therapy
… intra- and inter-tumoral heterogeneity, highly invasive growth patterns, and a hostile, immunosuppressive tumor microenvironment (TME). Fortunately, with the advent of CRISPR/Cas9 screening platform technologies, mechanisms of treatment resistance and novel therapeutic target identification can …
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Functional characterization of the novel centrosomal protein Nlp (ninein-like protein)
… responses as well as for embryonic development, invasive growth and metastasis. Thus, our findings raise the interesting possibility that an upregulation in the expression levels of structural centrosomal proteins could represent the molecular basis for developmental disorders and malfunctioning …
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
… invasion of the host tissue, and initiation of growth at the new location. The degradation of extracellular matrix and basal membranes by proteolytic enzymes makes possible the invasive growth of tumour cells. Numerous reports describe increased levels of proteolytic enzymes in invasive tumours. …
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Regulation of Growth and Development by the Small GTPase Cdc42p and the Transcription Factor Tec1p in <i>Saccharomyces cerevisiae</i>
… lulären Veränderungen beim sogenannten haploid invasiven Wachstum weniger tiefgreifend als bei der Pseudohyphenbildung. Die Signale, welche filamentöses/invasives Wachstum auslösen, werden über eine konservierte Mitogen-aktivierte Protein-Kinase (MAPK) Kaskade übertragen. Erstaunlicherweise …