Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"invasive disease"”.
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Understanding and targeting network-level sheddase regulation in invasive disease
… both to understand protease regulation in invasive disease (Chapter 4). Using combined measurement and computational modeling, we present a paradigm for monitoring and analyzing complex networks of protease activities that interface with signaling pathways to influence cellular migration in …
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Invasive disease by Haemophilus influenzae in Sweden in the era of the H. influenzae type b vaccine
… status of Haemophilus influenzae as an agent of invasive infection in Sweden? H. influenzae type b (Hib) used to be a common cause of meningitis, epiglottitis and severe sepsis in young children. In the late 1980’s an effective conjugated vaccine against Hib was developed and a dramatic fall in …
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Modelling the ecology and epidemiology of Streptococcus pneumoniae and their impact on conjugate vaccination
… protective against pneumococcal carriage and disease was introduced into the national immunisation programme in the UK. This thesis assists with the assessment of the population impact of this vaccine and its 13-valent successor. The thesis links the observations in pneumococcal disease …
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Novel molecular markers of disease-association among strains of Streptococcus suis: a genomic approach
… suis (S. suis) isolates into two populations, i) disease-associated and ii) non-disease associated. S. suis is a Gram-positive coccus that is considered one of the most important zoonotic bacterial pathogens of swine responsible for significant economic losses to swine production worldwide. …
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Dynamics of Naturally Acquired Antibody Against Haemophilus Influenzae Serotype 'A' and the Impact of Vaccination
… bacterial pathogen that can cause severe invasive disease. During the past two decades, the incidence of infections caused by H. influenzae serotype a (Hia) has increased in several parts of the world, particularly in Aboriginal populations of North America. Currently, there is no vaccine …
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Geospatial Variation of an Invasive Forest Disease and the Effects on Treeline Dynamics in the Rocky Mountains
… as to how these extreme environments harbor the invasive disease, and what the consequences may be for treeline dynamics. This dissertation research comprises three studies that investigate abiotic factors influential for blister rust infection in treeline whitebark pines, how disease coupled …
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Evaluation of a Multiplex Real-Time PCR Assay to Simultaneously Detect Streptococcus pneumoniae and Staphylococcus aureus in Nasal Samples
<p>Invasive disease caused by <em>Streptococcus pneumoniae</em> and <em>Staphylococcus aureus</em> is associated with nasal carriage of these bacteria. Use of a pneumococcal conjugate vaccine (PCV) in children altered nasal carriage rates and reduced infections due to <em>S. pneumonia. </em>Similar …
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Investigating The Ecology and Evolution of Normal Breast Tissues and Breast Cancer With Single Cell Genomics
… and interplay leads to the progression of invasive phenotypes such as Triple- Negative Breast cancer (TNBC). To do define the microenvironmental alterations that occur during cancer, we first established a human breast cell atlas, a reference of normal breast cell types from disease free …
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Quantitative approaches to understanding signaling regulation of 3D cell migration
… to form metastases is not only a hallmark of the disease but an essential step to mortality. Migration and dissemination are complex, multistep processes, and study of their regulation has been challenging. Metastases need only be driven by a rare subpopulation of tumor cells, and a portion of …
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The relative importance of barriers to cervical cancer screening in older women : A review of 140 women and their pap smear providers
… and women aged over 50 years with later, more invasive disease. One hundred and forty women aged between 50 and 69 years (M "'58.21 years) and 23 Pap smear providers completed a Cervical Cancer Screening Questionnaire designed to identify the relative importance of barriers to attendance for …
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Sensitivity and Specificity of Detecting Premalignant Pancreatic Lesions by Hyperpolarized Magnetic Resonance
… dissertation is to develop the capability of non-invasively detecting these premalignant precursor lesions in the pancreas prior to invasive disease by harnessing a non-invasive imaging modality called hyperpolarized magnetic resonance (HP MR) metabolic imaging. HP MR increases the signal of …
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Systems pathology: a bottom-up approach for understanding fibroblast-epithelial interactions in breast cancer
… cancer phenotypes and predicting the course of disease in tumor biopsies using an emerging chemical imaging technology. It has been described extensively that the tumor microenvironment, or stroma, can promote or suppress cancer phenotypes in many tissues. We hypothesized that interaction with …
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Decoding Breast Cancer Development Through Single Cell and Spatial Genomics
<p>Ductal carcinoma in situ (DCIS) is a preinvasive breast cancer in which cancer cells remain confined within the lumen of ducts. With the adoption of mammography, DCIS diagnoses have risen significantly, with approximately 50,000 new cases each year in the U.S. While 10-30% of DCIS patients …
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Landscape pattern and blister rust infection in whitebark pine (Pinus albicaulis) at alpine treeline, Northern Rocky Mountains, U.S.A.
… pine blister rust (Cronartium ribicola). This disease affects all five-needled white pines, but has caused particularly widespread mortality in whitebark pine. Objectives of this research were: 1) to characterize the landscape structure of the treeline study sites at Divide Mountain in Glacier …
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Biospectroscopy investigations Into cervical cytology
… tissue and is >95% effective in preventing re-invasive disease. However, removal of part of the cervix is linked to significant adverse sequelae, including preterm birth; with cone depth and radicality of treatment correlating to the frequency and severity of adverse events. Since pre-treatment …
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Strategies for the Selective Treatment of Cancer, Including the Identification and Mechanism of Action of Compounds That Induce G1 Cell Cycle Arrest
… trials that can be used to treat this highly invasive disease. The continued development of new chemotherapeutic agents and the identification of novel cellular targets are imperative for the successful treatment of cancer, as well as to gain a more complete understanding of how cells work. …
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Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
… therapy for bladder cancer patients with non-invasive disease. However, roughly 40% of patients exhibit no response, tumor recurrence or tumor progression following BCG treatment. Type I interferon (IFN-I) has potent anti-tumor effects against urothelial carcinoma (UC) and may be an …
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Applications of Proton Transfer Reaction and Selected Ion Flow Tube Mass Spectrometry in Health Monitoring
… the use of Volatile Organic Compounds (VOCs) in disease diagnosis and monitoring. VOCs may be found in the human body, in exhaled breath, faecal matter, urine, and skin. Analysis of the volatile profile produced in the human body can provide an indicator of metabolic status, allowing the …
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"Interrogating the genomic and metabolomic landscape of pseudohypoxic phaeochromocytoma and paraganglioma syndromes"
… PPGLs are associated with an aggressive disease course, with a 5-year overall survival of 50% in individuals with metastatic disease[3]. Predicting the development of a primary tumour or progression to metastatic disease throughout the life course with imaging/plasma metanephrines and …
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Bacterial colonization of the nasopharynx in paediatric patients with acute respiratory viral symptoms
Pneumococcal disease involves infections at both sterile and non-sterile sites, and accounts for considerable morbidity and mortality in Australia. Its public health significance has prompted the progressive introduction of vaccination against the most clinically significant capsular serotypes. …
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