Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"invadopodia"”.
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Invadopodia Formation in Breast Cancer
… utilise specialised membrane protrusions termed invadopodia. Rho family GTPases Rac and Cdc42 through interaction with effector proteins p21-activated kinases (PAKs) are known to regulate actin cytoskeletal dynamics. Indeed, PAK1/2 are over-expressed in breast cancer however the role of PAK1/2 in …
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Novel Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase and Lipogenesis
Invadopodia are membrane protrusions that facilitate matrix degradation and cellular invasion. Although cellular lipids have been implicated in several aspects of invadopodia assembly and function, the contribution of de novo fatty acid and phospholipid synthesis has not been elucidated. The data …
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A Genome-Wide RNAi Screen Identifies CDC-42 and GDI-1 as In Vivo Regulators of Invadopodia
… cells utilize F-actin-based structures called invadopodia to breach BM as they leave one tissue to enter another. Despite extensive study and interest in understanding invasion for its clinical importance, the molecular mechanisms regulating invadopodia and BM breach in vivo remain unclear. …
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Breast cancer cells cooperate during invasion and metastasis
… locally degrade the extracellular matrix using invadopodia, which are membrane protrusions enriched in matrix metalloproteinases. Importantly, invadopodia are required for metastasis of single cancer cells. However, whether invadopodia enable the collective invasion and metastasis of cancer cell …
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Regulation of Cell Invasion by the Podosome/Invadopod Protein Tks5
… cytoskeletal structures called podosomes/invadopodia. My doctoral thesis has focused on how Tks5 regulates the formation of these related structures and their impact on the invasive phenotype of cells. The podosomes of macrophages enable tissue invasion during immunosurveillance and wound …
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Abelson Kinase Based Regulation of Tumor Cell Invasion in HNSCC
… invasion is mediated in part by lamellipodia and invadopodia, two actin-based structures responsible for facilitating invasive movement. Key signaling pathways that govern lamellipodia and invadopodia production are hyperactivated or overexpressed in HNSCC, including EGFR, Src, Erk 1/2, and …
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Transcriptional regulation of metastatic progression in lung adenocarcinoma
… proteolytic membrane protrusions known as invadopodia to degrade the extracellular matrix. The formation and function of invadopodia are dependent on an isoform switch of the adaptor protein Tks5. The Tks5long isoform, which is upregulated in metastatic cells, is capable of localizing to …
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Cip4 and Src In Promoting The Migration and Invasion of Breast Cancers
… the novel finding that CIP4 localizes to invadopodia, which are finger-like projections of the actin cytoskeleton that are associated with matrix degradation and cellular invasion. Depletion of CIP4 in invasive cells impairs the formation of invadopodia and the degradation of gelatin. …
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Disulfide Bridging the Gap between Src and Cortactin: A New Paradigm in SH2 Domain-mediated Signaling
… is necessary for the formation of pro-invasive invadopodia. The work here also defines a paradigm shift in how SH2 domain-containing proteins interact with reciprocal binding partners. The second study characterizes potential structural changes in cortactin resultant from phosphorylation by …
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Processive Acceleration of Actin Barbed End Assembly by N-WASP
… actin polymerization drives extension of invadopodia and podosomes into the basement layer. In addition to activating Arp2/3 complex, N-WASP binds actin filament barbed ends, and both N-WASP and barbed ends are tightly clustered in these invasive structures. We used nanofibers coated with …
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Mathematical Modelling of Cancer Growth and Spread: The Role of Matrix Metalloproteinases
… how small protrusions from the cell termed invadopodia can affect the production of MMP-2 proteins and the focussing of ECM degradation, which has the consequence of allowing cancer cells to overcome barriers in the extracellular matrix.
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The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling
… modified Mcf10a cells to form gelatin-degrading invadopodia. Finally, we used a mouse prostate cancer model to show PTEN’s importance in controlling PI(3,4)P2 levels in vivo, pointing to a potential role for PI(3,4)P2 in PTEN-dependent tumourigenesis. I hope that the work described in this …
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The hypoxic tumor microenvironment regulates the LPA signaling axis to promote cancer cell invasion and metastasis
Le développement des métastases est la cause principale de mortalité des patients atteints de cancer, mais demeure un obstacle majeur aux traitements. L'hypoxie, une caractéristique commune des tumeurs solides, est fortement impliquée dans l'invasion cellulaire et le développement des métastases, …
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SMAD2, SMAD3 et SARA : des facteurs clés de la signalisation du TGFβ impliqués dans l’invasion des cellules cancéreuses stimulée par le microenvironnement hypoxique
La dissémination des cellules cancéreuses dans l’organisme et la formation de métastases est la principale cause de décès des patients atteints de cancer et un des grands défis pour le clinicien et le chercheur. Même si on sait que la dissémination métastatique est stimulée par le …