Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"intrinsic pathway"”.
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Streptococcal virulence and the coagulation system.
… surface proteins and components of the intrinsic pathway of coagulation and the kallikrein-kinin system in human plasma, as well as to how these surface proteins are produced in different growth phases. The interactions involve activation of the kallikrein-kinin system and inhibition of …
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Microfluidic Approaches to Thrombosis and Hemostasis: Towards a Patient-Specific Test of Antiplatelet Therapeutics and the Assessment of Coagulopathy in Hemophilic and Trauma Patients
… we have also developed a new model to assess the intrinsic pathway of coagulation under flow on collagen type I surfaces and investigated the role of the intrinsic pathway in recombinant coagulation factor VIIa (rFVIIa) therapeutic efficacy. We then extended this mechanistic investigation of …
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Nanosecond Pulsed Electric Field Induction of Programmed Cell Death Is Cell Type Dependent: An <i>in vitro</i> Study
… and caspase-independent programmed cell death pathways that originate from plasma membranes and/or intracellular membranes, especially mitochondria and endoplasmic reticulum. The specific aims are to: 1) determine whether nsPEFs induce cell death in E4 cells and Jurkat clones through caspase …
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An investigation into the mechanism of toxicity of zinc oxide nanoparticles.
… of Bax/Bcl2 leading to apoptosis through the intrinsic pathway. In addition, ZnO NPs induced phosphorylation of JNK, P38 and P53ser15. The results from our in vivo studies using a mouse model showed that ZnO NPs induce lipid peroxidation, oxidative DNA damage and apoptosis in liver which …
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Daple Orients and Patterns Sensory Hair Bundles in the Inner Ear
… cells necessitates the integration of diverse pathways. In the inner ear, at least two systems regulate the planar polarity of the hair bundle. The core planar cell polarity (PCP) proteins coordinate the orientations of hair cells across the epithelial plane. The cell-intrinsic patterning of …
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Novel Endogenous Antimicrobial Peptides
… molecular weight kininogen, a substrate in the intrinsic pathway of coagulation. Interestingly, the peptide HKH20 (His479 His498) from this domain was active in high salt, and highly resistant to degradation by various bacterial proteases. The understanding that heparin binding is a property of …
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"A syndrome so characteristic" Molecular and clinical studies of Fusobacterium necrophorum and Lemierre's syndrome
… coagulation. The contact system initiates the intrinsic pathway of coagulation and the release of the pro-inflammatory peptide bradykinin. We found that the contact system was activated at the surface of F. necrophorum, which may contribute the pathogenesis of thrombosis in Lemierre’s syndrome. …
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Computational Modeling And Simulation Of Thrombus Formation
… by other agonists besides thrombin and the intrinsic pathway in Chapter 4. An ensemble of probable parameter sets were estimated using nine experimental data sets from a cell-based model and then used to predict the thrombin generation in experiments using patient-derived plasma for coronary …
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Bim Mediates Imatinib-Induced Apoptosis of Gastrointestinal Stromal Tumors: Translational Implications
… FDG-PET response, and survival. Further, the intrinsic pathway of apoptosis was targeted therapeutically in GIST cells with the Bcl-2 inhibitor ABT-737. These studies show that BIM is upregulated in GIST cells and patient tumors after imatinib exposure, and correlates with induction of …
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In Vitro and in Vivo Pharmacodynamic Characterization of the Novel Plasma Kallikrein Inhibitor Pf-04886847
… factor XII (FXIIa) thereby potentiating the intrinsic pathway of coagulation. Thus, plasma kallikrein represents an important target for the development of novel anti-inflammatory and anti-thrombotic agents. The primary objective of this study was to develop and characterize a novel small …
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In vivo and in vitro studies of immunodeficiency in Ataxia-telangiectasia
… cycle checkpoint control and initiation of the intrinsic pathway of apoptosis. Ataxiatelangiectasia is classified as an immunodeficient disorder with patients commonly showing lymphopenia and abnormalities in immunoglobulin production. They also have a high incidence of leukaemia and lymphoma at …
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Identification and characterization of human plasma prekallikrein-prolylcarboxypeptidase interaction sites
… and the activation of the blood coagulation intrinsic pathway, both of which are deeply involved in human diseases such as angioedema, disseminated intravascular coagulation, acute respiratory distress syndrome and sepsis. Therefore, the identification of PRCP/PK binding sites, and PRCP …
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Epidermal Reactions to Injury with Implications for Innate Immunity
… indicates a reduced sensitivity to the extrinsic pathway of apoptosis and concomitantly, an apparently increased sensitivity to the intrinsic pathway of apoptosis. Taken together we hypothesize that this represents an epidermal response to cope with the external detrimental effects of inflammation …
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Anticancer activity of peach and plum extracts against human breast cancer in vitro and in vivo
… acids, triggered the extrinsic and intrinsic apoptotic pathways. The extrinsic death-receptor pathway involved the activation of caspase-8 followed by caspase-6, caspase-7, and PARP cleavage. By targeting the intrinsic pathway, the pro-apoptotic proteins cytochrome c, EndoG and AIF …
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ROLE OF THE Na,K-ATPase IN POLYCYSTIC KIDNEY DISEASE
… and extracellular signal-regulated kinase (ERK) pathway, its apoptotic effect was found to be through activation of the intrinsic pathway of apoptotic cell death. We also found ouabain to exacerbate the development and growth of cysts, both in cultured human ADPKD cells and metanephric organ …
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Genomics and virulence factors of Fusobacterium necrophorum
… clotting times by up to 7-fold for the extrinsic pathway, and up to 40-fold for the intrinsic pathway. The genome sequence data provides important information about F. necrophorum type strains and enables comparative study between strains and subspecies. Results from the leukotoxin and ecotin …
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EARLY GROWTH RESPONSE 1 (EGR1) AS A TUMOR SUPPRESSOR AND APOPTOSIS INDUCER IN RHABDOMYOSARCOMA
… EGR1 induced apoptosis through triggering the intrinsic apoptosis pathway and activating caspase cascades involving caspase 3 and caspase 9, which are essential mitochondrial apoptotic factors. Also, we observed the activation of two pro-apoptotic factors, BAX and dephosphorylated BAD, which …
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The chemotherapeutic potential of Boswellia carterii oleoresins
… Cytotoxicity is produced by activation of the intrinsic pathway of apoptosis. Furthermore, altered expression of cell cycle regulatory proteins leads to a G1 cell cycle arrest and cessation of cancer cell division. Boswellic acids likely produce this biological activity, though other, …
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Liposomes generated from proliposomes for treatment of glioma using Momordica charantia extracts
… apoptosis via mitochondrial cell death or intrinsic pathway. In conclusion, the study showed that liposomes generated from proliposomes were appropriate to target cancerous glial cells by binding plant extracts Momordica charantia and PTX to SPC and HSPC phospholipids. The cell death was …
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Effects of Ubiquinol with Fluid Resuscitation following Hemorrhagic Shock
… species (ROS) which are known to activate the intrinsic pathway of apoptosis and contribute to organ dysfunction.1 Ubiquinol is a potent free radical scavenger which is produced endogenously and functions as part of the mitochondrial respiratory chain.2 No study has been conducted to …
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