Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"intravitreal injection"”.
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A Lorentz-force actuated needle-free intraocular injection device
Intravitreal injection is a common treatment in ophthalmology, but it can lead to considerable patient anxiety and numerous complications. Lorentz-force actuated needle-free jet injection has been shown to successfully deliver fluid to various layers of skin, and, by its nature, may reduce …
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Drug Loaded Multifunctional Microparticles for Anti-VEGF Therapy of Exudative Age-related Macular Degeneration
… severe vision loss related to AMD. The current intravitreal injection of anti-VEGF (vascular endothelial growth factor) therapies using Avastin or Lucentis has several unmet clinical needs, such as to minimize the frequency of injection, to decrease the systemic side effects, and to evaluate the …
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Biodegradable in situ forming photocrosslinked implants for sustained protein delivery to the posterior segment of the eye
… can be injected through needles suitable for intravitreal injection, to provide sustained protein release for several months, with high daily release rates. Furthermore, protein activity was maintained at a high level throughout the duration of the release studies and through modification of …
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The role of VIP family members in diabetic retinopathy
… endothelial growth factor (VEGF). To date, intravitreal injection of agents directed against VEGF represents the elective DR therapy. However, they counteract efficaciently ocular neovascularization only in 50% of treated patients, suggesting that other pathogenic events may play an …
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Development and Characterization of Fluocinolone Acetonide Loaded Nanosized Lipid Carriers for Ocular Delivery via Subconjunctival Route: Synergistic Effect of Vitamin a Palmitate
… ocular bioavailability by subconjunctival injection. FA, a corticosteroid administered for inhibiting the ocular inflammation either as intravitreal injection or as intravitreal implants. The FA-NLCs were developed by using vitamin A palmitate as one of the lipid components, to get an …
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Effect of Drugs on Rabbit Retina
… Pegaptanib and ranibizumab are approved for injection into the vitreous. Bevacizumab is a cancer drug injected off-label intravitreally. In rabbit rod-mediated function was found depressed 8 weeks after a single injection of all three VEGF inhibitors. Rod bipolar cells were affected in the …
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TWEAK/Fn14 Pathway is Activated by Hypoxia and is a Novel Mediator of Retinal Neovascularization
… Finally, blockade of the TWEAK/Fn14 pathway, by intravitreal injection of Fn14-Fc decoy, was associated in a significant reduction in the extent of NV. Through my experiments, I have demonstrated that the TWEAK/Fn14 pathway is involved in the initiation and progression of NV, and ischemia-induced …
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Biopharmaceutic and Pharmacokinetic Evaluation of Hesperidin and Hesperetin for Ocular Delivery
… passive asymmetric transport. Results from the intravitreal kinetic studies of hesperidin, hesperetin and glucosyl-hesperidin (a water soluble derivative of hesperidin), following intravitreal injection, revealed that all three compounds have relatively short half-lives (< 8h) in the vitreous …
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Role of ephrinB2 and EphB4 in mouse retinal angiogenesis
… vessel development, the substances were injected intravitreally in P6 or P7 mice and after seven days in room air, retinal whole mounts were prepared and evaluated. <br>Concerning pathological angiogenesis, a single intravitreal injection of dimeric ephrinB2 or EphB4 increased the retinal …
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Connexin43 as a novel therapeutic target in age-related macular degeneration
… of the oxidative stress marker, nitrotyrosine. Intravitreal injection of a Cx43 mimetic peptide was used to modulate the function of Cx43 hemichannels in the AMD animal model. A single dose treatment showed a trend toward improvement in function of both rod and cone pathways when compared to …