Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"intravascular delivery"”.
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Gene therapy in mouse models of spinal muscular atrophy :
… from ̃14 to 200+ days. We show that direct delivery of scAAV-SMN into the central nervous system is able to more robustly rescue the phenotype of a mouse model of SMA compared to systemic, intravascular delivery. After determining the most efficacious route of injection, we seek to determine …
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Novel Approaches to Thalassaemia Gene Therapy
… gene therapy, namely via an in utero delivery route that in principle could be readily applicable worldwide and thus have a positive global impact in the treatment of the haemoglobinopathies. We started with a comparative study with ubiquitous and tissue specific promoter/enhancer …
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Mathematical modeling and simulation of intravascular drug delivery from drug-eluting stents with biodegradable PLGA coating
… for DES applications to improve the drug delivery and reduce adverse outcomes in patients. This dissertation aims to develop a mathematical model for describing the process of drug release from a biodegradable PLGA stent coating, and subsequent drug transport, pharmacokinetics, and …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
… uptake in the arterial wall. In this work local delivery of a hydrophobic drug from a drug-eluting stent implanted in a coronary artery is investigated using a mathematical model that couples drug diffusion and reversible binding in the arterial wall. The model is solved by the finite volume …