Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"intravasation"”.
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Identification of intravasation sites for metastatic biomarker development
… It has long been believed that the process of intravasation is preceded by local invasion, and yet, several studies have detected circulating tumour cells at earlier disease stages. This suggests that intravasation may occur without detectable invasion into the surrounding microenvironment. To …
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Engineering the tumor microenvironment using microfluidics : effects of cell-cell interactions and endothelial barrier function on tumor cell intravasation
… key step during cancer metastasis is cancer cell intravasation (entry of cancer cells into the blood vessels) that results in tumor cell dissemination into distant organs. During this process, tumor cells navigate a complex microenvironment and interact with multiple cell types. This thesis is …
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Genetic and mechanistic determinants of prostate cancer progression and metastasis
… mechanistic elements involved with tumor cell intravasation into lymphatics. The results from this work have shown that loss of Protein 4.1B, a 4.1/ezrin/radixin/moesin (FERM) domain-containing cytoskeletal protein, is a frequent event in prostate cancer. The significance of this finding was …
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RNA Deregulation in Metastatic Breast Cancer
… including invasion of the surrounding stroma, intravasation into lymph or blood vessels, survival during transport with successful evasion of the immune system, extravasation and final outgrowth in the new microenvironment. At each step cells acquire new properties through the alteration of …
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Roles of the MicroRNA miR-31 in tumor metastasis and an experimental system for the unbiased discovery of genes relevant for breast cancer metastasis
… cascade: local invasion, one or more early post intravasation events, and metastatic colonization. At a mechanistic level, miR-31 impaired metastasis via the pleiotropic suppression of a cohort of target genes that otherwise operate to promote metastasis, including integrin a5, radixin, and RhoA. …
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Cellular Plasticity And Heterogeneity: Implications In Tumor Cell Invasion And Metastasis
… (TAMs), leading to greater bloodstream intravasation. Consistent with these findings, metastatic progression in human PDAC was associated with activation of MYC signaling pathways and enrichment for MYC amplifications specifically in metastatic patients. These results implicate MYC …
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Tumor cell deformability in the metastatic cascade
… from a tumor, exit surrounding tissue during intravasation, enter into circulation and eventually stop at a distant site for extravasation. Here, we measure the physical changes in the deformability of tumor cells, indicated by the length of time required to pass through a microfluidic …
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LINEAGE TRACING REVEALS PAEP AS A CHEMOTHERAPY-INDUCED METASTATIC DRIVER AND EXPOSES METABOLIC VULNERABILITIES OF CIRCULATING TUMOR CELLS IN BREAST CANCER
… paradox via a model in which intravasation triggers an acute adaptive response: respiration is transiently restrained to minimize ROS (short‐term survival), while OXPHOS programs remain transcriptionally primed as a “metabolic scar” for rapid re‐engagement after extravasation. …
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Initiale Auswirkungen der Marknagelung auf die kortikale Perfusion und Fetteinschwemmung in der Schafstibia - Vergleich eines experimentellen Bohrsystems mit dem konventionellen AO-Bohrsystem und der ungebohrten Marknagelung -
Die Marknagelung ist ein bewährtes Verfahren zur Behandlung von Frakturen langer Röhrenknochen. Jedoch führen sowohl die gebohrte als auch die ungebohrte Nagelung zur Reduzierung der kortikalen Perfusion und zu lokaler Fetteinschwemmung. In dieser Studie wurde ein experimentelles Bohrsystem mit …
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MUC13 Enhances Colorectal Cancer Metastasis
… successful in forming a metastatic lesion. After intravasation, anchorage independent survival (Anoikis resistance) of primary tumor cell is one of the key steps in metastasis.</p> <p>The mucin MUC13 when aberrantly overexpressed in cancer has been found to lead to poor outcomes in Pancreatic, …