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Showing 1 to 20 of 34 for “"intrauterine growth restriction"”.
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Role of PABP4 in intrauterine growth restriction
… in pregnancies which exhibit intra-uterine growth restricted (IUGR) fetuses from e15.5, and an increased prevalence of late-gestational fetal death (akin to stillbirth). Stillbirth affects approximately 1 in 225 pregnancies in the UK, and IUGR is not only a major risk factor for stillbirth …
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Effects of dietary intervention on inflammation and intrauterine growth restriction in neonatal piglets
Intrauterine growth restriction (IUGR), a form of fetal malnutrition that leads to small for gestational age (SGA) infants, is a condition that affects 7.5 million children born worldwide. Infants affected by IUGR are more prone to lengthy hospital stays, repeated infections, and neurodevelopmental …
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Development in children born very preterm after intrauterine growth restriction with abnormal fetal blood flow
Delivery of fetuses with intrauterine growth restriction (IUGR) with abnormal umbilical artery blood flow in the second trimester represents a clinical dilemma. So far, no evidence based management protocols are available adressing when to deliver these fetuses. The high risk of hypoxia and fetal …
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Intrauterine growth restriction (IUGR) and birth outcomes in a cohort of HIV-infected pregnant women in Cape Town, South Africa
Background: Intrauterine growth restriction (IUGR) is a major contributory factor of perinatal morbidity and mortality. This suboptimal growth is associated with infants being small-for-gestational age. In addition to genetic and placental factors, maternal factors such as infection are also …
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Axis of placental ageing in adverse pregnancy outcomes
… impacts both maternal and fetal outcomes. Intrauterine growth restriction (IUGR) is defined as the inability of the fetus to reach normal growth potential within the uterus as a result of various genetic, environmental, or placental factors. Premature ageing of the placenta in pregnancy …
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Muscle Growth and Development in Intrauterine Growth Restricted Pigs
Intrauterine growth restriction causes impaired growth and development of mammalian fetus, and leads to long-term negative effect on postnatal growth. Among domestic animals, pigs exhibit the most severe naturally occurring IUGR and reduced postnatal muscle growth. The objectives of this research …
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Aggregatibacter actinomycetemcomitans serotypes in gingival crevicular fluid of mothers delivering preterm.
… weight (LBW), is a direct consequence of PTB or intrauterine growth restriction, and is a major determinant of neonatal infant morbidity and mortality. The primary aim of this study was to determine if the prevalence of Aggregatibacter actinomycetemcomitans (Aa) serotypes in gingival crevicular …
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The role of thyroid hormones in placental development and the importance of the thyroid hormone transporter MCT8
… important for fetoplacental development. Human intrauterine growth restriction (IUGR) is associated with malplacentation and reduced fetal circulating concentration of THs. The expression of the plasma membrane TH transporters MCT8, MCT10, LAT1, LAT2, OATP1A2 and OATP4A1 was characterised in …
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The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation
… has been associated with preeclampsia and intrauterine growth restriction as well as other adverse pregnancy outcomes such as miscarriage, preterm birth and intrauterine death. Hypertensive disorders of pregnancy, including pre-eclampsia are one of the leading causes of maternal mortality …
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The perinatal and obstetric outcomes of triplet conceptions at Groote Schuur Hospital in the five-year period: 1 January 2012 to 31 December 2016
… miscarriage, twin to twin transfusion syndrome, intrauterine growth restriction and discordant growth, stillbirths, preterm delivery, premature rupture of membranes and low birth weight. Neonatal complications included respiratory distress syndrome or hyaline membrane disease, intraventricular …
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Role of Chlamydia trachomatis infection in adverse pregnancy outcomes
… including controversial data on miscarriage, intrauterine growth restriction and low birth weight, however the causative mechanisms are unknown. A successful pregnancy requires normal endometrial stromal cell (ESC) decidualisation and trophoblast invasion, processes that involve chemokine …
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Role of transcription factor Runx1 in uterine stromal cell differentiation and maternal-fetal interaction during mouse pregnancy
… disorders, including spontaneous miscarriage, intrauterine growth restriction and preeclampsia. Our study revealed that the expression of Runx1, a transcription factor belonging to the runt-domain family, is markedly elevated in the uterine stromal cells during decidualization. Conditional …
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Expression and Function of Ca2+-Activated K+ Channels in Uterine Arteries
… and heightened risk of preeclampsia and fetal intrauterine growth restriction (IUGR). The present study tested the hypothesis that calcium-activated potassium (KCa) channels play an essential role in uterine vascular adaptation to pregnancy, which is inhibited by chronic hypoxia during …
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Maternal and placental adaptations to hypoxia
… adaptive responses, including alteration in the growth and patterns of gene expression in the chorioallantoic placenta and increases in vascularity within the uterine mesometrial compartment. Uterine mesometrial blood vessels were more numerous and their diameters expanded in animals exposed to …
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The role of Ras-related C3 botulinum toxin substrate 1 (RAC1)-dependent pathway in the regulation of uterine function during early pregnancy
… cells, which become secretory and support the growth of the embryo before placentation. At the same time, new blood vessels begin to form in the maternal decidua from pre-existing vasculature. This process termed angiogenesis is critical for the establishment of the placenta and the maintenance …
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Aggressive Behavioral Phenotype in Intrauterine Growth Restricted (IUGR) Baboons Exposed to Moderate Nutrient Restriction Early in Development
… could be an association between aggression and intrauterine growth restriction (IUGR), which can result from low maternal food intake during pregnancy. The main hypotheses of this study are [1] IUGR offspring demonstrate higher rates of aggressive behavior and [2] IUGR offspring attain higher …
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Fetal Cardiac Function and Venous Circulation - Experiences with Velocity Vector Imaging
Placental dysfunction resulting in intrauterine growth restriction (IUGR) is a common complication of pregnany and severe IUGR, with ensuing fetal hypoxia is an important cause of perinatal mortality and morbidity. Doppler studies of fetal and maternal vessels are routinely used for fetal …
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The Role of Histone Deacetylases in Cytokine Regulation in Human Gestational Tissues
… pathologies of pregnancy such as pre-eclampsia, intrauterine growth restriction and preterm birth have been associated with variations in cytokine expression, both from the placenta and gestational membranes, and in the maternal circulation. Following their investigation as anticancer drugs, …
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The Role of Oxytocin in Bovine Satellite Cell Proliferation and Differentiation
… contribute to skeletal muscle development and growth. In this dissertation, we tested this hypothesis with in-vivo and in-vitro studies in intrauterine growth restriction (IUGR) sheep, caloric restricted (CR) calves, tamoxifen (TAM) treated heifers, and bovine satellite cells (BSCs), …
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The impact of placental SLC2A3 (GLUT-3) RNA interference on fetal growth and physiology at mid-gestation in sheep
… substrate for fetal oxidative processes and growth. In order for glucose to be transported from maternal to fetal circulation in the ruminant placenta, it must be sequentially transported by SLC2A1 (GLUT-1) on the maternal-fetal syncytial layer, then by SLC2A3 (GLUT-3) on the apical …
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