Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"intratumour heterogeneity"”.
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Elucidating intratumour heterogeneity through investigation of clonal, transcriptomic, and proteomic features across models of triple negative breast cancer and diffuse intrinsic pontine glioma
Intratumour heterogeneity defines the diversity found within those malignant populations that take up residence within our bodies as cancer. These cellular societies comprise actors of diverse talents, from those suited to rapid proliferation, to drug resistance, to the cells that leave the commune …
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Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinoma
… cancer. ccRCCs exhibit considerable genetic intratumour heterogeneity, and current therapies lack long-term efficacy due to drug resistance. Novel therapeutic targets are thus required to combat this disease. The most effective targets are likely to be factors essential for maintaining ccRCC …
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Clonal deconvolution of transcriptomic signatures and their spatial organisation in a mouse model of breast cancer
Intratumour heterogeneity is a phenomenon during cancer progression in which cancer cells diverge and form clonal populations with distinct phenotypic, genetic, or epigenetic states within the same tumour. This intrinsic heterogeneity provides a fuel for cancer evolution enabling tumour cell …
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Investigating the regulation of APOBEC mutagenesis in cancer
… to mediate cancer initiation, progression, intratumour heterogeneity and responses to therapy, including immunotherapy. The findings detailed might therefore contribute to the ability to understand and control the natural history of cancer across multiple cancer types.
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Investigating the Genomics and Heterogeneity of Childhood Non-Hodgkin Lymphoma
… settings. It is now recognised that genetic intratumour heterogeneity (ITH) contributes to drug resistance in malignant disease. However, many questions remain unresolved, and improved theoretical and experimental model systems will likely be required to resolve them. To this latter end, a …